Actual status of veralipride use

Abstract

During the climacteric period, several symptoms exist that motivate women to seek medical advice; one of the most common is the hot flush, which presents in 75%–85% of these during a variable time span. For the treatment of hot flush, several non-hormonal treatments exist; among them, veralipride has shown to be a useful treatment of vasomotor symptoms during the climacteric period. In recent times, several medical societies have discredited its use. The purpose of this review, therefore, is to define a measured position in relation to the use of this drug. On completion of this review, it was possible to conclude that this drug has an antidopaminergic mechanism of action. The recommended schedule is: 100 mg/day for 20 days, with 10 days drug free. Since the risk of undesirable secondary effects such as galactorrhea, mastodynia, and extrapyramidal can increase with use, no more than 3 treatment cycles are recommended. This drug has a residual effect that can allow drug-free intervals, which permit a longer time between schedules.

The dopamine D2 receptors antagonist Veralipride inhibits carbonic anhydrases: solution and crystallographic insights on human isoforms

“…[5] Veralipride is recognized as a valuable therapeutic option for managing vasomotor symptoms associated with climacteric conditions, particularly in cases where hormone therapy (HT) is contraindicated or not accepted. [6] Additionally, it can be employed in conjunction with other medications that do not provide adequate control of vasomotor symptoms. The therapeutic effect of veralipride on hot flushes is attributed to a dual mechanisms: inhibition of hypothalamic dopaminergic neurons and stimulation of the endogenous opioid system.…”

“…Veralipride is recognized as a valuable therapeutic option for managing vasomotor symptoms associated with climacteric conditions, particularly in cases where hormone therapy (HT) is contraindicated or not accepted [6] . Additionally, it can be employed in conjunction with other medications that do not provide adequate control of vasomotor symptoms.…”

Exploring the Dynamical Nature of Intermolecular Hydrogen Bonds in Benzamide, Quinoline and Benzoic Acid Derivatives

“…Benzamide is a derivative of benzoic acid. Some substituted benzamides are well-known commercial drugs, e.g., procainamide, imatinib and veralipride [52][53][54]. Benzamides are still an attractive group of compounds, especially in drug design, where very often their derivatives are taken into consideration as compounds that show a specific type of biological activity.…”