Actualités de la prévention et du traitement des mucites orales chez les enfants cancéreux : recommandations pratiques

Bousaadani, A. El; Eljahd, L.; Abada, R.; Rouadi, Sami; Roubal, M.; Mahtar, M.

doi:10.1016/j.canrad.2015.11.006

Cited by 13 publications

(5 citation statements)

References 36 publications

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“…Oral Mucositis Assessment Scales (OMAS) [6] Erythema and ulceration at 9 sites Oral Assessment Guide (OAG) [7] Objective (erythema), symptoms (pain, salivary change) and function Eastern Cooperative Oncology Group (ECOG) [8] Mucositis severity is differently classified based on the anatomic site of development Common Terminology Criteria for Adverse Event (CTCAE) [9] Mucositis severity measure scale based on anatomic site of development and on the kind of treatment, either chemo or radiotherapy MacDibbs mouth assessment [10] 14-item instrument grouped into four sections: the patient information section includes seven items that measure the patient's oral symptoms including problems with pain, dryness, eating, talking, swallowing, tasting and saliva production barrier agents, thereby covering injured mucosae as a salve or ointment.. Evaluating clinical practice guidelines, Sung et al reported their findings regarding cryotherapy, lower level light therapy (LLLT) and keratinocyte growth factor (KGF) as an OM prevention tool, however, with unconvincing recommendations for use [9].…”

Section: Scale Descriptionmentioning

confidence: 99%

“…Whilst several treatment options are available, there is no clear consensus regarding prevention, especially for young people. Current recommendations for the management of OM are very limited, and the standard of care for this complication has hitherto been palliative [ 8 ]; the aim of OM management is to control symptoms via topical or systemic analgesics and the topical application of barrier agents, thereby covering injured mucosae as a salve or ointment..…”

Section: Introductionmentioning

confidence: 99%

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Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review

et al. 2023

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Introduction Oral mucositis (OM) is a major side effect of cancer therapy, which is associated with significant symptoms, treatment delays and increased costs for the health system. It is an important component of the quality of life of cancer patients and, until now, there has been no gold standard regarding prevention or treatment of this pathology. Notwithstanding the paucity of treatment guidelines (due to limited evidence from high-quality, rigorous studies), sodium bicarbonate (SB) rinses are one of the most used agents for OM management. Objectives A systematic review (2000–2022) was performed in order to compare and examine different agents versus sodium bicarbonate (SB) in preventing or treating OM. Sources Eleven randomized controlled trials (RCT) were evaluated: four were conducted for the prevention and seven for the management of OM. The risk of bias of RCTs was assessed using the revised Cochrane risk of bias tool for randomized trials. Study selection According to the RoB2 evaluation for randomized trials, four RCTs were judged to be at a high risk of bias, two were rated as ‘problematic’, while five were deemed to be a low risk of bias. Conclusions The results revealed that there was no evidence for supporting SB in OM treatment regarding management and prevention. Clinical significance Results showed in this review takes on a strategic importance in the use of SB for OM management or prevention; indiscriminate use of SB could be counterproductive because it causes a sudden pH increase and it delays proper OM pharmacological treatment.

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Section: Scale Descriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review

et al. 2023

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“…Oral mucositis is likely to develop in 40% of children receiving standard-dose chemotherapy, 80% of patients receiving radiation therapy for head and neck cancers, and 75% of patients undergoing bone marrow transplantation [35] . In recent years, several studies have shown that the use of low energy laser was particularly interesting in the prevention and treatment of radiation-induced or chemically induced mucositis [36] . Also, maintaining good oral hygiene is important in preventing and reducing the severity of oral mucositis [37] .…”

Section: Oral Mucositismentioning

confidence: 99%

Dental management of the childhood cancer patient

Garza-Avilés¹,

Coronado²,

Longoria³

et al. 2021

Int. J. Appl. Dent. Sci.

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Introduction: More than 40,000 children undergo cancer treatment each year. In the long term, children and adolescents are at risk of developing oral complications over time, especially in relation to teeth. Objective: To analyze the literature about dental management of patients with childhood cancer, including oral examination before treatment, preventive strategies, dental treatments and oral complications related to cancer therapy. Methodology: The PubMed database was used; review and research articles were identified where oral and dental complications in pediatric patients diagnosed with cancer were mentioned. The terms "cancer", "childhood", "dental", "complications" were used. Results: The oral examination before a treatment indicates that thanks to the help of an examination prior to starting any treatment, the severity of oral complications can be reduced. Preventive strategies indicate that the pediatric dentist should be involved with the patient from the diagnosis, developing oral care plans that are individualized for each patient. Dental treatments must be performed after evaluating the child's tolerance to avoid any complications. Oral complications related to cancer therapy such as mucositis, xerostomia, and infections must be anticipated during cancer treatment. Conclusion:As pediatric dentists we need to participate at the beginning of treatment at the time of cancer diagnosis, developing prevention plans and oral care related to the patient's needs. Support from the oncology team is needed to provide optimal treatments.

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“… 6 Although there is no specific treatment for oral mucositis, a number of pharmacological and non-pharmacological strategies are available to suppress its development. 7 Low energy laser is one of these strategies. 8 Recent evidence demonstrates the promising effect of natural agents, including probiotics in healing oral mucositis lesions.…”

Section: Introductionmentioning

confidence: 99%

Probiotics for the Management of Oral Mucositis: An Interpretive Review of Current Evidence

et al. 2022

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Mucositis is one of the major side effects of anti-cancer therapies. Mucositis may lead to other abnormalities such as depression, infection, and pain, especially in young patients. Although there is no specific treatment for mucositis, several pharmacological and non-pharmacological options are available to prevent its complications. Probiotics have been recently considered as a preferable protocol to lessen the complications of chemotherapy, including mucositis. Probiotics could affect mucositis by anti-inflammatory and anti-bacterial mechanisms as well as augmenting the overall immune system function. These effects may be mediated through anti microbiota activities, regulating cytokine productions, phagocytosis, stimulating IgA releasement, protection of the epithelial shield, and regulation of immune responses. We have reviewed available literature pertaining to the effects of probiotics on oral mucositis in animal and human studies. While animal studies have reported protective effects of probiotics on oral mucositis, the evidence from human studies is not convincing.

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Actualités de la prévention et du traitement des mucites orales chez les enfants cancéreux : recommandations pratiques

Cited by 13 publications

References 36 publications

Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review

Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review

Dental management of the childhood cancer patient

Probiotics for the Management of Oral Mucositis: An Interpretive Review of Current Evidence

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