Actualización en cáncer de próstata

Martı́nez, B.; Póveda, Manuel Durán; Encinas, M. Sánchez; Villaverde, R. Molina

doi:10.1016/s0304-5412(13)70509-2

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…Frailty syndrome was assessed according to the frailty physical phenotype proposed by Fried et al: (1) weight loss, defined as an unintentional loss of 4.5 kg or more in the last year; (2) self-reported exhaustion assessed by the question "How often in the last week did you feel that everything you did led to fatigue? ", with the criterion being met when participants answered "always" or "often"; (3) decreased physical activity, assessed with the International Physical Activity Questionnaire.…”

Section: Frailty Syndrome Assessmentmentioning

confidence: 99%

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Comparison of Frailty Criteria, Cognitive Function, Depressive and Insomnia Symptoms in Men with Localized and Advanced Prostate Cancer under Androgen Deprivation Therapy

et al. 2023

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Background: Prostate cancer (PCa) is considered one of the most important medical problems in the male population, with a very high incidence after the age of 65. Frailty represents one of the most critical issues facing healthcare due to its inherent relationship with poor healthcare outcomes. The physical phenotype of frailty syndrome based on Fried criteria has been associated with poor outcomes, morbidity, and premature mortality. To date, there are few studies that have analyzed frailty syndrome in patients with localized and advanced (mPCa) disease under androgen-deprivation therapy. Objective: Our goal was to assess whether there are differences in frailty criteria between mPCa and localized PCa. We also evaluated the role of other geriatric variables such as depressive and insomnia symptoms, which are frequently reported in cancer patients. Methods: In this cross-sectional study, frailty syndrome was evaluated in both groups, as well as its possible relationship with cognitive functions, depressive and insomnia symptoms, and other clinical variables related to PCa and its treatment. Frailty was defined on Fried’s criteria: low lean mass, weakness, self-reported exhaustion, low activity level, and slow walking speed; prefrailty was defined as having one or two of those criteria and frailty as having three or more, depressive symptoms were defined by the Yesavage scale, cognitive functions with the Mini-Mental examination test, and insomnia symptoms by the Athens scale and self-reported health status. Results: The prevalence of prefrailty/frailty was slightly higher in mPCa compared to localized PCa (81.5% versus 72.3%, respectively), however by analyzing each of the frailty criteria, two of them were significantly reduced in mPCa compared to localized PCa patients, e.g., gait speed (p = 0.001) and muscle strength (p = 0.04). The reduced gait speed and muscle strength in mPCa were not due to the increased age in mPCa group, or to an increase in comorbidities or shorter time under androgen-deprivation therapy. The symptoms of insomnia were significantly higher in mPCa patients compared to those with localized PCa (p < 0.05) whereas cognitive functions or depressive symptoms were not significantly different between the two groups. Conclusion: Patients with mPCa under androgen-deprivation therapy display higher alterations in gait speed and muscular strength and insomnia symptoms, thus interventions should be aimed to reduce these alterations in order to limit adverse outcomes related to them and to improve quality of life in these patients.

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Section: Frailty Syndrome Assessmentmentioning

confidence: 99%

“…Prostate cancer is considered one of the most important medical problems in the male population, with a very high incidence after the age of 65 [1]. With an estimated 1.4 million new cases and 375,000 deaths worldwide, prostate cancer was the second most common cancer and the fifth leading cause of cancer deaths among men in 2020 [2].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Frailty Criteria, Cognitive Function, Depressive and Insomnia Symptoms in Men with Localized and Advanced Prostate Cancer under Androgen Deprivation Therapy

et al. 2023

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“…Among the most prevalent cancers, prostate cancer (PCa) is the second most common type with an estimated 1.4 million new cases and 375,000 deaths worldwide per year [ 7 , 8 , 9 ]. Previous studies have shown that advanced age is the primary risk factor, with more than 75% of all PCas being diagnosed in men over 65 years of age [ 10 , 11 ]. Among patients with PCa, 12–15% had regional disease and only 4–5% had distant disease at the time of diagnosis [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Frailty Syndrome in Men with Metastatic Prostate Cancer: A Scoping Review

Mafla-España

Torregrosa

Cauli

2023

JPM

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Most patients with metastatic prostate cancer (mPCa) are older. In addition, current geriatric oncology guidelines suggest that all cancer patients aged over 70 years should undergo a comprehensive geriatric assessment (CGA), with the identification of frailty syndrome being crucial for clinical decisions. Frailty can be associated with lower quality of life (QoL) and interfere with the feasibility or side effects of oncology treatments. Methods: We performed a systematic literature search to evaluate frailty syndrome and associated alterations related to CGA impairment by searching in different academic databases (PubMed, Embase, and Scopus). The identified articles were reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Of the 165 articles consulted, 7 met our inclusion criteria. Analysis of data related to frailty syndrome in patients with mPCa showed a prevalence between 30–70% depending on the tool used. Additionally, frailty was associated with other CGA assessments and QoL evaluation outcomes. In general terms, CGA scores for patients with mPCa were lower than those for patients without metastasis. Furthermore, functional QoL appeared to be worse for patients with metastasis, and global QoL (burden) was more strongly associated with frailty. Conclusion: Frailty syndrome was related to a poorer QoL in patients with mPCa and its evaluation should be considered in clinical decision-making and when choosing the most appropriate active treatment, if any, to increase survival.

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“…Al respecto, la evidencia acerca de estas pautas para la prevención y diagnóstico del CaP no muestra consenso, por un lado hay quienes afirman que se debe realizar el tamizaje a todos los hombres a partir de los 40 años 12, 14-17 , por otro lado, se enfatiza en la necesidad de búsqueda de síntomas y posteriormente el ETR a partir de los 65 años, dado que la mayoría de los casos de CaP se detectan a partir de esta edad [18][19][20][21] . Asimismo, la literatura señala que después de los 70 años no se deben realizar las pruebas o cuando la expectativa de vida esté limitada a menos de 10 años por otras enfermedades 18,22,23 .…”

Section: Introductionunclassified

Prevalencia de factores de riesgo y sintomatología prostática en indígenas de Tabasco

Sánchez

Acuña

et al. 2021

Rev Cuid

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Introducción: El cáncer de próstata, es un problema de salud pública, la neoplasia que se diagnostica con mayor frecuencia y segunda causa de muerte en los hombres. Poco se sabe de este problema en población indígena, por lo cual, los conocimientos actuales son demandantes en la prevención primaria. Objetivo: analizar la prevalencia de sintomatología prostática y factores de riesgo entre varones indígenas, Centro, Tabasco. Material y Métodos: estudio descriptivo correlacional, diseño transversal, muestra de 281 hombres de la etnia chontal de 40 y más años de las comunidades; Tamulté de las Sabanas, Aniceto y Tocoalt. Se utilizó el cuestionario de síntomas prostáticos y entrevista de factores de riesgo. Resultados: 52.7% sin escolaridad, 47.7% son campesinos, edad media 55 años, 16.7% con sintomatología prostática de moderada a severa. Factores de riesgo; 44.5% mediano y 55.5% alto riesgo. La prueba de Chi cuadrada de Pearson entre la variable edad y sintomatología prostática tuvo una asociación de p=.000. Un valor de p=.166 entre la edad y los factores de riesgo; hombres de menor edad presentaron más factores de riesgo. Ninguno se ha realizado los exámenes de detección integral. Discusión y conclusiones: coincide con otros estudios la prevalencia de síntomas prostáticos en adultos mayores, es preocupante la prevalencia de factores de riesgo en todos los participantes, mismos que se han observado en hombres con diagnóstico de cáncer de próstata, es importante crear estrategias de prevención con miras en los estilos de vida saludable.

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Actualización en cáncer de próstata

Cited by 3 publications

References 29 publications

Comparison of Frailty Criteria, Cognitive Function, Depressive and Insomnia Symptoms in Men with Localized and Advanced Prostate Cancer under Androgen Deprivation Therapy

Comparison of Frailty Criteria, Cognitive Function, Depressive and Insomnia Symptoms in Men with Localized and Advanced Prostate Cancer under Androgen Deprivation Therapy

Analysis of Frailty Syndrome in Men with Metastatic Prostate Cancer: A Scoping Review

Prevalencia de factores de riesgo y sintomatología prostática en indígenas de Tabasco

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