Actualización práctica de las recomendaciones del Grupo de Psoriasis de la Academia Española de Dermatología y Venereología (GPS) para el tratamiento de la psoriasis con terapia biológica. Parte 2 «Manejo de poblaciones especiales, pacientes con comorbilidad y gestión del riesgo»

Carrascosa, José Manuel; Puig, L.; Belinchón, Isabel; Salgado‐Boquete, Laura; Alcázar, E. del; Lencina, Juan José Andrés; Moreno, Daniel; Cueva, Pablo de la

doi:10.1016/j.ad.2022.01.024

Cited by 23 publications

(1 citation statement)

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“…According to guidelines, the decision-making process should be determined by the disease severity and impact on quality of life, the presence of comorbidities, previous administration and response to previous treatments, taking also into consideration patient's preferences. [31][32][33][34] Psoriasis is associated with increased risk of comorbidities, including psoriatic arthritis, hidradenitis suppurativa, and inflammatory bowel disease. 1,6,35 To date, there are a total of 38 clinical trials registered in "www.clinicaltrials.gov" focusing on the utilization of bimekizumab; some of them are still ongoing and have not yet produced results.…”

Section: Bimekizumab In Special Situationsmentioning

confidence: 99%

Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and Perspectives

Camiña-Conforto¹,

Arrom²,

López‐Ferrer³

et al. 2023

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Psoriasis is a chronic systemic inflammatory disease that significatively impairs patients’ quality of life. Biological treatments are highly effective and safe and have led to breakthroughs in the management of patients with moderate-to-severe psoriasis. However, therapeutic response can be unsatisfactory or lost with time, leading to discontinuation of treatment. Bimekizumab is a humanized monoclonal antibody that specifically inhibits both interleukin (IL)-17A and IL-17F. The efficacy and safety of bimekizumab in moderate-to-severe plaque psoriasis has been demonstrated in Phase 2 and Phase 3 clinical trials. Bimekizumab may offer some advantages over other biological treatments, making it especially indicated for certain patients. This narrative review aims to summarize the latest published evidence on the use of bimekizumab for the treatment of moderate-severe plaque psoriasis, focusing on patient selection and therapeutic perspectives. Bimekizumab has been shown to be more efficacious than adalimumab, secukinumab and ustekinumab in clinical trials, with high estimated probabilities of achieving complete (approximately 60%) or almost complete clearance (approximately 85%) of psoriasis at weeks 10–16, and a good safety profile. Response to bimekizumab is usually fast and maintained in the long term for both biologic-naive patients and those resistant to previous biologic treatments. The usual maintenance dose of 320 mg every 8 weeks makes bimekizumab especially convenient for non-compliant patients. Moreover, the efficacy and safety of bimekizumab have also been demonstrated in psoriasis affecting challenging-to-treat areas, psoriatic arthritis and hidradenitis suppurativa. In conclusion, dual inhibition of IL-17A and IL-17F with bimekizumab is a good therapeutic option for moderate-to-severe psoriasis.

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