Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain: the involvement of DNA methylation in the prefrontal cortex

Jang, Jae-Hwan; Song, Eun-Ji; Do, Young-Ho; Ahn, Sora; Oh, Ju-Young; Hwang, Tae‐Kon; Ryu, Yeonhee; Jeon, Songhee; Song, Mi‐Yeon; Park, Hi-Joon

doi:10.1097/j.pain.0000000000002031

Cited by 53 publications

(20 citation statements)

References 77 publications

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“…Our results showed that EA treatment relieved the mechanical hyperalgesia and anxiety-and depressive-like behaviors. The results are consistent with the previous studies showing that EA has analgesic, antianxiety, and antidepressantlike effects on NeuP (Li et al, 2014;Jang et al, 2020).…”

Section: Discussionsupporting

confidence: 93%

Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala

et al. 2021

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Neuropathic pain (NeuP) is an important clinical problem accompanying negative mood symptoms. Neuroinflammation in the amygdala is critically involved in NeuP, and the dopamine (DA) system acts as an important endogenous anti-inflammatory pathway. Electroacupuncture (EA) can improve the clinical outcomes in NeuP, but the underlying mechanisms have not been fully elucidated. This study was designed to assess the effectiveness of EA on pain and pain-related depressive-like and anxiety-like behaviors and explore the role of the DA system in the effects of EA. Male Sprague-Dawley rats were subjected to the chronic constrictive injury (CCI) model to induce NeuP. EA treatment was carried out for 30 min once every other day for 3 weeks. The results showed that CCI caused mechanical hyperalgesia and depressive and anxiety-like behaviors in rats and neuroinflammation in the amygdala, such as an increased protein level of TNFα and IL-1β and activation of astrocytes. EA treatment significantly improved mechanical allodynia and the emotional dysfunction induced by CCI. The effects of EA were accompanied by markedly decreased expression of TNFα, IL-1β, and glial fibrillary acid protein (GFAP) in the amygdala. Moreover, EA treatment reversed CCI-induced down-regulation of DA concentration, tyrosine hydroxylase (TH) expression, and DRD1 and DRD2 receptors. These results suggest that EA-ameliorated NeuP may possibly be associated with the DA system to inhibit the neuroinflammation in the amygdala.

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Section: Discussionsupporting

confidence: 93%

Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala

et al. 2021

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“…(6) Acupuncture exerts analgesic effects by mediating mitogen-activated protein kinase (MAPK) signaling pathways, including the spinal cord p38/MAPK ( Fang et al, 2013 ; Liang et al, 2016 ), extracellular-signal-regulated kinase ( Choi et al, 2012 ; Park et al, 2014 ), c-Jun N-terminal kinase ( Lee et al, 2013 ), and nuclear factor kappa-B pathways ( Park et al, 2002 ). (7) Acupuncture exerts analgesic effects through epigenetic regulation of genes in tissues and cells, including DNA methylation ( Jang et al, 2021 ), histone modification ( Lai et al, 2012 ), and microRNA regulation ( Liu and Wu, 2017 ; Zou et al, 2019 ). These theories have provided a theoretical basis for evaluating the effectiveness of acupuncture in PHN treatment and have laid the foundation for follow-up research.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of different acupuncture therapies on postherpetic neuralgia: A Bayesian network meta-analysis

Cui

Wang

et al. 2023

Front. Neurosci.

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BackgroundPostherpetic neuralgia (PHN) is a common, complex, and refractory type of neuropathic pain. Several systematic reviews support the efficacy of acupuncture and related treatments for PHN. Nevertheless, the efficacy of various acupuncture-related treatments for PHN remains debatable.ObjectiveWe aimed to assess the efficacy and safety of acupuncture-related treatments for PHN, identify the most effective acupuncture-related treatments, and expound on the current inadequacies and prospects in the applications of acupuncture-related therapies.MethodsWe searched PubMed, Cochrane Central Register of Controlled Trials, Embase, Web of Science, Google Scholar, four Chinese databases (China National Knowledge Infrastructure, China Biomedical, Chongqing VIP, and Wan Fang databases), clinical research registration platform (World Health Organization International Clinical Trial Registration platform, China Clinical Trial Registration Center) for relevant studies. We also examined previous meta-analyses; gray literature; and reference lists of the selected studies. We then evaluated the risk of bias in the included studies and performed a Bayesian multiple network meta-analysis.ResultsWe included 29 randomized controlled trials comprising 1,973 patients, of which five studies showed a high risk of bias. The pairwise meta-analysis results revealed that the efficacy of all acupuncture-related treatments for pain relief related to PHN was significantly better than antiepileptics. The network meta-analysis results showed that pricking and cupping plus antiepileptics were the most effective treatment, followed by electroacupuncture (EA) plus antiepileptics for pain relief in patients with PHN. EA plus antiepileptics ranked the best regarding reduced Pittsburgh Sleep Quality Index (PSQI) and Self-Rating Depression Scale (SDS) scores in patients with PHN. No results were found regarding the total response rate or quality of life in this study. Acupuncture-related treatments showed a lower incidence of adverse events than that of antiepileptics.ConclusionAcupuncture-related therapies are potential treatment options for PHN and are safe. Pricking and cupping plus antiepileptics, are the most effective acupuncture-related techniques for pain relief, while EA plus antiepileptics is the best acupuncture-related technique for improving PHN-related insomnia and depression symptoms. However, owing to the limitations of this study, these conclusions should be cautiously interpreted, and future high-quality studies are needed.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021226422, identifier CRD42021226422.

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“…Moreover, there are many pain related journals, which indicates that acupuncture intervention on pain is being widely studied. [60][61][62][63][64][65][66][67][68][69][70][71][72] But the top productive journals on acupuncture for CP's average IF is not high (4.19). Therefore, the international influence of research on acupuncture for CP is relatively insufficient.…”

Section: Discussionmentioning

confidence: 99%

Knowledge Mapping of International Research on Acupuncture for Chronic Pain: A Bibliometric Analysis

Jiao¹,

Ding²,

Jin³

et al. 2022

JPR

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Introduction With the wide acceptance of acupuncture, many papers and guidelines recommend that acupuncture is effective for chronic pain (CP). In this study, we applied bibliometric methods to analyze the current research situation of acupuncture intervention in CP, to gain insight into the current situation and future development trend of this field. Material and Methods Science Citation Index Expanded was searched for publications related to acupuncture for CP between 1900 and 2022. VOSviewer, CiteSpace and Thomson Data Analyzer were used to analyze the annual publication, authors and cited authors and their countries (regions) and institutions, journals and cited journals, cited references, co-occurrence keywords, burst keywords, and the relevant centrality. Results A total of 1968 papers were retrieved, the annual publications have shown a rapid growth trend in the recent 20 years. The USA (708) and the Kyung Hee University (31) were the most productive country and institution, respectively, while the USA (0.37) and University of Maryland (0.13) had the highest centrality. MacPherson, Hugh published the most papers in this field (29), and Vickers, A J were the most influential author (289 times cited). Journal of Alternative and Complementary Medicine was the most productive journal (92), whereas PAIN was the most influential one (4743 times cited). Breivik, H’s (2006) paper had the most citation count (3025), while Furlan’s (2005) paper had the highest centrality (0.23). The research focuses in this field mainly include pain, electroacupuncture, Low back pain, Systematic review, Randomized controlled trial etc. Researchers are currently paying more attention to the psychological problems caused by CP. Conclusion The research of acupuncture for CP will be further expanded. International cooperation of this research field needs to be further strengthened. More high-quality designed trials need to be conducted.

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Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain: the involvement of DNA methylation in the prefrontal cortex

Abstract: Supplemental Digital Content is Available in the Text. Acupuncture treatment for 6-month period altered DNA methylation patterns, particularly in the prefrontal cortex, in a mouse model of chronic neuropathic pain.

Cited by 53 publications

References 77 publications

Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala

Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala

Efficacy of different acupuncture therapies on postherpetic neuralgia: A Bayesian network meta-analysis

Knowledge Mapping of International Research on Acupuncture for Chronic Pain: A Bibliometric Analysis

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