Acupuncture attenuates extracellular glutamate level in global ischemia model of rat

Lee, Gi-Ja; Yin, Chang Shik; Choi, Seok-Keun; Choi, Sang‐Jun; Yang, Janghoon; Lee, Hyejung; Park, Hun-Kuk

doi:10.1179/016164109x12537002794200

Cited by 23 publications

(9 citation statements)

References 21 publications

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“…9 At present, EA is widely used experimentally and clinically to treat disorders of the nervous system, such as stroke. [10][11][12][13][14][15] However, there are few studies and reports on the influence of EA after TBI, especially regarding its effect on the regional blood flow and neuronal TGIF expression involved in cellular apoptosis during the acute stage.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Blood Flow and Apoptosis-Associated Factor with Electroacupuncture in a Traumatic Brain Injury Rat Model

et al. 2013

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Objective Electroacupuncture (EA) has been widely used for treatment of stroke, but there is little information on the effect of EA on the neuroprotective function in traumatic brain injury (TBI). The aim of the present study was to investigate the protective effects and mechanisms of EA treatment in a TBI rat model. Methods Male Sprague–Dawley rats were randomly divided into four groups: sham operation, TBI control, TBI+EA treated for 30 min or TBI+EA treated for 60 min. The animals were treated with EA immediately after TBI. The EA was applied at acupuncture points GV20, GV26, LI4 and KI1 with a dense-dispersed wave, frequencies of 0.2 and 1 Hz, and amplitude of 1 mA for 30 or 60 min. Regional blood flow, cell infarction volume, extent of neuronal apoptosis, expression of cell apoptosis-associated factor transforming growth-interacting factor (TGIF) were studied, and functional outcome was assessed by running speed test. All tests except regional blood flow were performed 72 h after TBI onset. Results Immediately after TBI, compared with the TBI control groups, the regional blood flow was significantly increased by EA treatment for 60 min. Compared with the TBI controls 72 h after TBI, the TBI-induced run speed impairment, infarction volume, neuronal apoptosis and apoptosis-associated TGIF expression were significantly improved by EA treatment. Conclusions The treatment of TBI in the acute stage with EA for 60 min could increase the regional blood flow and attenuate the levels of TGIF in the injured cortex, might lead to a decrease in neuronal apoptosis and cell infarction volume, and might represent one mechanism by which functional recovery may occur.

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Section: Introductionmentioning

confidence: 99%

Cerebral Blood Flow and Apoptosis-Associated Factor with Electroacupuncture in a Traumatic Brain Injury Rat Model

et al. 2013

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“…As evidences given by recently extensive reports, the beneficial effects of acupuncture on brain ischemic damage in vivo or in vitro mainly focus on microcirculation [24], anti-apoptotic [25], anti-inflammation [26], neuron protection [27], brain metabolism [28]. Our previous studies indicated that acupuncture combined with basic modern medicine treatment showed a great effect on stroke patients' self-care ability and quality of life in clinic trial [12], and the underlying mechanism may be associated with improving cerebral haemodynamics and neuron protective effect under a special stimulated parameter on a special acupionts revealed by animal researches [13, 29, 30].…”

Section: Discussionmentioning

confidence: 99%

A Study on the Effect of Neurogenesis and Regulation of GSK3β/PP2A Expression in Acupuncture Treatment of Neural Functional Damage Caused by Focal Ischemia in MCAO Rats

Luo

Fan

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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170 SD rats were randomly divided to five groups. Rats in model group, no-acupuncture group, and acupuncture group were subjected to MCAO surgery. Acupuncture group received 3 consecutive acupuncture treatments at a parameter that deep in 2 mm towards apex nasi and thrust/lifted at 3 times per second for 1 minute, while model group and no-acupuncture group were no-intervention control groups. Serious neural functional damage and sharp decrease of cerebral blood flow, obvious infarction volume, increased nestin mRNA expression, and immunopositive cells population (nestin+, BrdU+ and nestin/BrdU+) were found in MCAO rats which had not been observed in normal group and sham-operated group. However, the damage was attenuated by rat's “self-healing” capacity 3 days after MCAO. And the “self-healing” capacity can be strengthen by acupuncture treatment through increasing cerebral blood flow, neurogenesis, and regulation of gene transcription or GSK-3β and PP2A expression. In conclusion, the present study indicates that the underlying mechanism of acupuncture treatment on neural functional damage caused by focal ischemia injury is a multiple interaction which may involve improved cerebral blood supply, neurogenesis, and regulation of gene transcription or GSK-3β and PP2A expression in MCAO rats.

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“…Lee et al reported that acupuncture can attenuate extracellular glutamate levels in a global ischemia model in rat. In the study, the authors found that acupuncture at GB34 and GB39 significantly suppressed glutamate function compared to control animals [22]. Later, Kim et al demonstrated that acupuncture at HT7 can inhibit methamphetamine-induced behaviors, dopamine release and hyperthermia in the nucleus accumbens through the group II metabotropic glutamate receptors [23].…”

Section: Evidence From Electrochemical Studiesmentioning

confidence: 96%

Functional Imaging and Physiological Modulation with Acupuncture in Parkinson’s Disease and Nonhuman Primate Models of Dopamine Dysfunction

Yin¹,

Quintero²,

Zhang³

2019

Acupuncture - Resolving Old Controversies and Pointing New Pathways

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Here we review functional imaging and neurophysiological evidence for the preclinical and clinical use of electroacupuncture, a non-pharmaceutical-based therapeutic strategy, to relieve parkinsonian symptoms. Outcomes from those studies provide evidence that the effect of electroacupuncture can be objectively measured in nonhuman primate models of Parkinson's disease and in patients with Parkinson's disease. In addition, the evidence continues to support that electroacupuncture can be used in preclinical and clinical studies simply, safely, and effectively as an alternative and complementary treatment for disorders in Parkinson's disease.

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Acupuncture attenuates extracellular glutamate level in global ischemia model of rat

Abstract: This result suggests that the effect of acupuncture might be closely associated with modulation of the brain glutamate release in the ischemic condition.

Cited by 23 publications

References 21 publications

Cerebral Blood Flow and Apoptosis-Associated Factor with Electroacupuncture in a Traumatic Brain Injury Rat Model

Cerebral Blood Flow and Apoptosis-Associated Factor with Electroacupuncture in a Traumatic Brain Injury Rat Model

A Study on the Effect of Neurogenesis and Regulation of GSK3β/PP2A Expression in Acupuncture Treatment of Neural Functional Damage Caused by Focal Ischemia in MCAO Rats

Functional Imaging and Physiological Modulation with Acupuncture in Parkinson’s Disease and Nonhuman Primate Models of Dopamine Dysfunction

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