“…Main findings AD [38] Cognition regions AD [39] Hippocampal Depression [40] Limbic system, amygdala, and the ACC CM [41] DMN Stroke [42] Bilateral motor cortex Stroke [43] Motor-related network MCI [44] Cognition regions Ischemic stroke [45] Sensorimotor network Depression [40] Limbic system, amygdala, and ACC Stroke [46] PM/SMA and SMG RFPN Migraine [47] ACC and PCC Stroke [48] chronic pain [49][50][51] Networks: DMN, salience, central executive, and sensorimotor ALBP [52] Limbic, pain, attentional and somatosensory system, and DMN CD [53] Afferent processing network and DMN Smoking craving [54] SN Hypertension [55] Frontal lobe, cerebellum, and insula PMS [56] Aberrant neural activity Cardiovascular [57] Cortical, hypothalamus and brainstem stimulation; and specific visualization of acupoints. Specifically, the following conclusions can be drawn from the physiological mechanism of acupuncture at acupoints and its specificity research: there are differences in the brain connectivity and local activities between single and different acupoints, and combination points have more wide activate areas than single point; the regulate areas are mostly related to the emotional, cognitive, and painful functions; limbic system and subcortical areas are found to be hubs after acupuncture; verum acupuncture may increase DMN, PAG, PCC, and pain matrix connectivity compared with sham acupuncture, and sham acupuncture influenced less functional areas than true acupuncture; the local brain functional activities of ipsilateral acupuncture are different from those of contralateral acupuncture; the effect of acupuncture has an obvious individual difference; and there are different degrees of changes in brain functional connectivity among different acupunctures, intensities, methods, and different subjects, and an adjusting acupuncture approach can be used as a means of regulating brain activity.…”