Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial

Kim, Jung-Eun; Seo, Byung-Kwan; Choi, Jin-Bong; Kim, Hyeong-Jun; Kim, Tae-Hun; Lee, Minhee; Kang, Kyung‐Won; Kim, Joohee; Shin, Kyung-Min; Lee, Seung‐Hoon; Jung, So-Young; Kim, Ae‐Ran; Shin, Mi-Suk; Jung, Heejung; Park, Hyo-Ju; Kim, Sung-Phil; Baek, Yong-Hyeon; Hong, Kihyon; Choi, Sun-Mi

doi:10.1186/s13063-015-0857-0

Cited by 29 publications

(46 citation statements)

References 37 publications

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“…RCTs of alternative medicines and self-therapies for CFS/ME have increased since the late 2000s. Regarding RCTs of alternative medicines such as acupuncture, qigong, and abdominal tuina [53,[64][65][66], 10 RCTs were selected in our review process, but 6 were excluded due to low quality (a Jadad score less than 3) or too few participants. A systematic review also presented the limitations of acupuncture treatment due to the low quality of RCTs and the weak strength of evidence along with the weak potential to improve the symptoms of CFS/ME [91].…”

Section: Discussionmentioning

confidence: 99%

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Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

et al. 2020

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Background: Although medical requirements are urgent, no effective intervention has been proven for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). To facilitate the development of new therapeutics, we systematically reviewed the randomized controlled trials (RCTs) for CFS/ME to date. Methods: RCTs targeting CFS/ME were surveyed using two electronic databases, PubMed and the Cochrane library, through April 2019. We included only RCTs that targeted fatigue-related symptoms, and we analyzed the data in terms of the characteristics of the participants, case definitions, primary measurements, and interventions with overall outcomes. Results: Among 513 potentially relevant articles, 55 RCTs met our inclusion criteria; these included 25 RCTs of 22 different pharmacological interventions, 28 RCTs of 18 non-pharmacological interventions and 2 RCTs of combined interventions. These studies accounted for a total of 6316 participants (1568 males and 4748 females, 5859 adults and 457 adolescents). CDC 1994 (Fukuda) criteria were mostly used for case definitions (42 RCTs, 76.4%), and the primary measurement tools included the Checklist Individual Strength (CIS, 36.4%) and the 36-item Short Form health survey (SF-36, 30.9%). Eight interventions showed statistical significance: 3 pharmacological (Staphypan Berna, Poly(I):poly(C 12 U) and CoQ 10 + NADH) and 5 non-pharmacological therapies (cognitive-behavior-therapy-related treatments, graded-exercise-related therapies, rehabilitation, acupuncture and abdominal tuina). However, there was no definitely effective intervention with coherence and reproducibility. Conclusions: This systematic review integrates the comprehensive features of previous RCTs for CFS/ME and reflects on their limitations and perspectives in the process of developing new interventions.

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Section: Discussionmentioning

confidence: 99%

“…[41,44,48,49,51]. In addition, 3 RCTs of graded-exercise-related therapies [52,54,55] and 3 RCTs of integrative, consumer-driven rehabilitation [63], acupuncture [64] and abdominal tuina [66] showed a significantly effect of the intervention compared to the control (Table 3).…”

Section: Rcts With Pharmacological Interventionsmentioning

confidence: 99%

Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

et al. 2020

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“…Дані досліджень останніх років свідчать про те, що АП здатна стимулювати нейропластичність (НП) шляхом збільшення експресії глутаматаспартат транспортеру в астроцитах, (пригнічуючи експресію рецептора NMDA) і підвищення експресії рецептора АМРА [5]. В експерименті доведено, що ЕАП може підвищувати експресію ДОР [11], в той час як ДОР-активація стимулює глутаматаспартат транспортер в астроцитах і, тим самим, прискорює зниження концентрації позаклітинного глутамату [9], захищаючи головний мозок від ексцайтотоксичності .…”

Section: East European Journal Of Neurology східно-європейський невроunclassified

“…На противагу цьому, в роботах останніх років продемонстровано, що АП може збільшувати рівні ГАМК в головному мозку, здійснюючи тим самим НП-дію [5].…”

Section: East European Journal Of Neurology східно-європейський невроunclassified

Experience of application of acupuncture in pain syndrome as a means of increasing the «pain threshold»

Svyrydova¹

2016

East Europ. Journ. of Neurology

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The paper shows ways to optimize the training of doctors in the field of Reflexotherapy. Used problem methodology of training, provided experience in organizing practical classes, clinical examinations of patients. Іmportance in the process of training specialists at the Department of Neurology and Reflexology is given to practical classes, where students must realize in a real clinical situation, at the bed of the patient, they mastered theoretical ideas about the mechanisms of therapeutic action of reflexotherapy in certain diseases and conditions, indications and contraindications to the conduct of procedures Reflexotherapy, the method of selecting patients for reflexology and recreating the acquired skills of acupuncture diagnosis and procedures. Reflexology A significant role in the preparation of future reflexology doctors is also given to seminars, which have the role of a kind of chain between theoretical knowledge and their practical implementation in clinical work: it requires a logical doctor’s actions and skills in making specific decisions. Practical’s are carried out for various types of seminars, but the most popular are the colloquium workshop and clinical-workshop. Situation tasks are made on the basis of the «Bank» of clinical treatments according to different nosology’s. The presented clinical cases based on data analysis of patients who were under the supervision of teachers of the Department of Neurology and Reflexology and were used in the preparation of seminars-clinical treatments, dealing with the treatment of patients with pain syndromes using reflexotherapy. Presented clinical cases of effective use of acupuncture treatment in patients with pain syndromes due to reduction of «pain threshold».

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“…Western medicine offers no objective diagnostic methods or effective therapies for CF and the recommended drugs have many side effects [ 8 – 11 ]. CFS and ICF patients tend to be interested in complementary and alternative medicine treatments [ 9 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Validation of the qi blood yin yang deficiency questionnaire on chronic fatigue

Kim

2016

Chin Med

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BackgroundChronic fatigue (CF) reflects an imbalance of inter-organ functions or of the four essential physiological components qi, blood (xue), yin, and yang. CF can be subdivided into different patterns. However, there are no diagnostic methods for CF. This study aimed to clinically validate a pattern identification method by identifying correlations between CF and responses to the qi blood yin yang deficiency questionnaire (QBYY-Q).MethodsParticipants were recruited between May and June 2014 through the Kyung Hee University Korean Medicine hospital website and via posters and comprised 129 CF patients diagnosed with the United States Centers for Disease Control and Prevention (1994) criteria. Participants who had organic diseases that explained the CF were excluded. A total of 159 participants were asked to complete the QBYY-Q, the fatigue severity scale, and the Chalder fatigue scale. The latter two questionnaires were used to assess convergent validity with the QBYY-Q. Among the 129 CF participants, 70 and 59 had chronic fatigue syndrome and idiopathic chronic fatigue, respectively. Two Korean medical doctors independently assessed participants’ qi, blood, yin, and yang deficiency patterns using QBYY deficiency pattern identification guidelines. Based on the results of a preliminary study of the QBYY-Q, we selected 32 reliable items for symptoms corresponding to each deficiency pattern. The items were used to estimate internal consistency and construct validity. Multinomial logistic regression analysis was performed for scores on each deficiency pattern.ResultsThe data were means and standard deviations or numbers of participants and proportions for continuous and categorical variables, respectively. A statistical significance level of P < 0.05 was assumed. The QBYY-Q showed satisfactory internal consistency. Explanatory factor analysis extracted two factors for each deficiency pattern. The percentages of explained variance for qi, blood, yin, and yang deficiency were 45.1, 58.0, 52.2, and 63.4 %, respectively. Each QBYY-Q deficiency score was positively associated with each corresponding deficiency pattern. Qi deficiency was used as a reference category. Odds ratios of blood, yin, and yang deficiency were 10.97, 10.69, and 14.64, respectively.ConclusionThe QBYY-Q was suitable for estimating the influences of qi, blood, yin, and yang deficiencies in CF.Trial registration This trial was registered with the Korean Clinical Trial Register (KCT0001199)Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-016-0092-y) contains supplementary material, which is available to authorized users.

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Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial

Cited by 29 publications

References 37 publications

Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

Experience of application of acupuncture in pain syndrome as a means of increasing the «pain threshold»

Validation of the qi blood yin yang deficiency questionnaire on chronic fatigue

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