Acupuncture for Climacteric-Like Symptoms in Breast Cancer Improves Sleep, Mental and Emotional Health: A Randomized Trial

Abstract

Objective: Breast cancer is the most prevalent malignant neoplasm in women. Optimal treatment frequently includes a hormonal-blockage phase maintained for 5-10 years. Pharmacologic agents used for this blockage induce many climacteric-like symptoms, which often exact a heavy toll on patients' quality of life. Acupuncture has had promising results for treating climacteric-like symptoms induced by hormonal blockage, but there is no evidence of efficacy for controlling hot flashes. Materials and Methods: This trial used acupuncture to treat the climacteric-like symptoms of patients with breast cancer, focusing on the mental, physical, and genitourinary symptoms and sleep disturbances, to determine the influence of acupuncture treatment. The randomized placebo-controlled trial, at a university-based cancer center, with blinded data collectors, compared an Acupuncture group (A), a Sham-Acupuncture group (S), and a Wait-List Control group (C). The patients were receiving tamoxifen. Group A had 10 weekly sessions of manual Acupuncture; Group S had 10 weekly sessions of Sham Acupuncture; and Group C spent 10 weeks on a Wait-List. The main outcome measures were the Beck Depression Inventory-II (BDI-II), the Pittsburgh Sleep Quality Index (PSQI), and the Menopause Rating Scale (MRS). Results: Primary analysis revealed differences among the groups' improvements in scores for the 3 questionnaires (P < 0.001), The A group had significant improvements on the BDI-II (P < 0.001), PSQI (P < 0.002), and MRS (P < 0.004) compared to the S group in a post hoc analysis. Conclusions: Acupuncture improved sleep, and mental and emotional distress symptoms induced by hormonal blockage in patients with breast cancer. Clinical Trial: This trial was registered at CAAE as trial #: 37758414.8.0000.0065.

Efficacy of acupuncture treatment for breast cancer-related insomnia: study protocol for a multicenter randomized controlled trial

“…This analysis could guide tailored treatment decisions. Another study assessed acupuncture’s efficacy for breast cancer-related insomnia using only the Pittsburgh Sleep Quality Index ( 58 ), while this study used multiple assessment tools for a comprehensive evaluation.…”

Acupuncture in cancer care: a narrative review

“…A review by Choi et al 44 including six RCTs, demonstrated that acupuncture was superior to sham acupuncture, drugs, or hormone therapy for insomnia treatment. A recent RCT with blinded data collectors and using the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) guidelines found a significant benefit of acupuncture in improving sleep quality in women with climacteric-like symptoms associated with breast cancer treatment 45 .…”

Mechanism and application of acupuncture and electro‐acupuncture associated with cancer therapy

“…However, a retrospective study found that AC was as effective as medication in treating cancer‐related depression 180 . Another clinical trial involving 302 breast cancer patients demonstrated that AC improved cancer‐related anxiety and depression 71,76–79 . AC can significantly reduce anxiety levels in patients with advanced gastric cancer 80 .…”