Acupuncture for improving gait disturbance in Parkinson’s disease: A study protocol for a pilot randomized controlled trial

Jang, Jung‐Hee; Kim, Hyuntae; Jung, Inchul; Yoo, Ho-Ryong

doi:10.1016/j.eujim.2018.04.002

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…The blood samples of patients with PD were collected before (V1) and after five (V5) as well as eight sessions (V8) of acupuncture. Detailed information about the study design, inclusion criteria, interventions, and outcome measurements can be found in the clinical protocol study [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Investigation of Therapeutic Response Markers for Acupuncture in Parkinson’s Disease: An Exploratory Pilot Study

et al. 2021

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In this preliminary pilot study, we investigated the specific genes implicated in the therapeutic response to acupuncture in patients with Parkinson’s disease (PD). Transcriptome alterations following acupuncture in blood samples collected during our previous clinical trial were analyzed along with the clinical data of six patients with PD, of which a representative patient was selected for transcriptomic analysis following acupuncture. We also examined the changes in the expression of PD biomarker genes known to be dysregulated in both the brain and blood of patients with PD. We validated these gene expression changes using quantitative real-time polymerase chain reaction (qPCR) in the blood of the remaining five patients with PD who received acupuncture treatment. Following acupuncture treatment, the transcriptomic alterations in the representative patient were similar to those induced by dopaminergic therapy. Among the PD biomarkers, ankyrin repeat domain 22 (ANKRD22), upregulated following dopaminergic therapy, and synapsin 1 (SYN1), a common gene marker for synaptic dysfunction in PD, were upregulated following acupuncture. These alterations correlated with changes in gait parameters in patients with PD. Our data suggest ANKRD22 and SYN1 as potential biomarkers to predict/monitor therapeutic responses to acupuncture in patients with PD, especially in those with gait disturbance. Further research is needed to confirm these findings in a large sample of patients with PD.

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Section: Methodsmentioning

confidence: 99%

Investigation of Therapeutic Response Markers for Acupuncture in Parkinson’s Disease: An Exploratory Pilot Study

et al. 2021

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“…The study protocol was approved by the institutional review board of the Clinical Trial Center at Dunsan Korean Medicine Hospital, Daejeon University as previously published 27 and is shown in Supplementary Methods in more detail. Computer-generated block randomization was used to allocate all participants to the control (n = 13) or intervention (n = 13) groups and was performed by an independent statistical researcher who was not involved in the study.…”

Section: Methodsmentioning

confidence: 99%

Gait Disturbance Improvement and Cerebral Cortex Rearrangement by Acupuncture in Parkinson’s Disease: A Pilot Assessor-Blinded, Randomized, Controlled, Parallel-Group Trial

Jang

Park

An³

et al. 2020

Neurorehabil Neural Repair

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Background Parkinson’s disease (PD) leads to impaired mobility and limited independence. Objective We investigated the effects of acupuncture on gait disturbance and analyzed hemodynamic changes caused by acupuncture in the cerebral cortex of patients with PD. Methods Participants (n = 26) with gait disturbance due to PD were randomly assigned to the intervention (acupuncture twice a week for 4 weeks + conventional therapy) or control (conventional therapy) groups. We analyzed gait parameters using the GAITRite system and hemodynamic responses in the cerebral cortices using functional near-infrared spectroscopy, Unified Parkinson’s Disease Rating Scale (UPDRS) scores, neurotransmitter levels, as well as the immediate effects of acupuncture in patients with PD. Results The participants tended to walk with hypometric gait (high cadence, short steps) overground. After acupuncture treatment, those in the intervention group showed a significant reduction in cadence and the UPDRS scores involving “walking and balance” compared with those in the control group ( P = .004 and P = .020, respectively); the stride, swing, and single support times were significantly increased ( P = .006, P = .001, and P = .001, respectively). Oxyhemoglobin levels in the intervention group while walking on a treadmill were significantly increased in the prefrontal and supplementary motor areas. The oxyhemoglobin levels in the prefrontal cortex and swing time revealed significant positive correlations. Conclusions Our findings indicated that acupuncture tended to improve hypometric gait and rearranged activation of the cerebral cortex. Thus, acupuncture may be a useful complementary treatment for gait disturbance, including hypometric gait, in patients with PD. Trial Registration Number. Clinical Research Information Service (KCT0002603), https://cris.nih.go.kr/cris/index.jsp

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“…The study protocol was approved by the Institutional Review Board (IRB) of the Clinical Trial Center at Dunsan Korean Medicine Hospital, Daejeon University (DJDSKH-17-BM-20), as previously published [18]. Patients with PD and gait disturbances who met the inclusion criteria were enrolled and randomly assigned to the control group (conventional treatment alone) or intervention group (acupuncture + conventional treatment).…”

Section: Methodsmentioning

confidence: 99%

“…Inclusion criteria consisted of the following: (1) a diagnosis of PD made by a neurologist; (2) ability to walk 10 m; (3) Hoehn an Yahr scale stage 1-4; (4) a stable dose of conventional treatment for at least one month before enrollment [18].…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study

et al. 2020

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Acupuncture is increasingly being used as an alternative treatment for patients with Parkinson’s disease (PD). We aimed to evaluate the effects of acupuncture on gait-related brain function in patients with PD using functional near-infrared spectroscopy (fNIRS). Twenty-four patients with PD were randomly assigned to intervention (acupuncture twice a week for 4 weeks) or control (non-treatment) groups. fNIRS experiments applying a block design were performed at baseline (0 weeks) and 4- and 8-week follow-up and cortical activation and connectivity were evaluated. After acupuncture treatment, oxy-hemoglobin (HbO) levels in the intervention group were significantly increased in the primary motor cortex (M1), supplementary motor area (SMA), and prefrontal cortex (PFC). Furthermore, following acupuncture treatment in the intervention group, the connectivities in the M1 and PFC regions increased. The results show that acupuncture may be a useful complementary treatment for gait disturbances in patients with PD, and fNIRS can be applicable to evaluate neural plasticity directly. The evaluation method in this paper can be used to assess the neural plasticity related to various rehabilitation techniques.

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Acupuncture for improving gait disturbance in Parkinson’s disease: A study protocol for a pilot randomized controlled trial

Cited by 7 publications

References 23 publications

Investigation of Therapeutic Response Markers for Acupuncture in Parkinson’s Disease: An Exploratory Pilot Study

Investigation of Therapeutic Response Markers for Acupuncture in Parkinson’s Disease: An Exploratory Pilot Study

Gait Disturbance Improvement and Cerebral Cortex Rearrangement by Acupuncture in Parkinson’s Disease: A Pilot Assessor-Blinded, Randomized, Controlled, Parallel-Group Trial

Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study

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