Acupuncture for multiple sclerosis: A literature review

Khodaie, Faezeh; Abbasi, Naghmeh; Kazemi, Amir Hooman; Zhao, Baixiao; Moghadasi, Abdorreza Naser

doi:10.1016/j.msard.2022.103715

Cited by 11 publications

(7 citation statements)

References 24 publications

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“…32–34 Complementary and alternative medicine has been used by 58% of people with MS around the world, and acupuncture has been shown to have therapeutic effects on MS-associated fatigue. 14…”

Section: Discussionmentioning

confidence: 99%

“…[32][33][34] Complementary and alternative medicine has been used by 58% of people with MS around the world, and acupuncture has been shown to have therapeutic effects on MS-associated fatigue. 14 In the current trial, we investigated the effectiveness of acupuncture plus amantadine on fatigue and quality of life of individuals with RRMS. The results demonstrated that the severity of fatigue was reduced in both groups.…”

Section: Discussionmentioning

confidence: 99%

“…7 Acupuncture has been practiced for more than 2000 years; however, scientific investigation into its mechanisms of action has only come about relatively more recently. There is already evidence of beneficial effects of acupuncture on quality of life, gait impairment, bladder dysfunction, fatigue, pain and functional neural deficits in people with MS, [8][9][10][11][12][13][14] and the neuroimmune-endocrine network appears to be involved. 15 Acupuncture can regulate specific neuropeptides in the CNS, including dopamine, and stimulate the hypothalamus to enhance secretion of adrenocorticotrophic hormone and β-endorphin, which can regulate helper T cell function.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of acupuncture for fatigue in patients with relapsing-remitting multiple sclerosis: a randomized controlled trial

et al. 2023

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Background: Fatigue is experienced by more than 65% of individuals with multiple sclerosis (MS). Some studies have supported the effectiveness of acupuncture in improving the symptoms of MS. Objective: The present research was intended to investigate the effectiveness of acupuncture plus amantadine compared with amantadine alone on fatigue in patients with relapsing-remitting MS (RRMS) in the remission stage of the disease. Methods: In this randomized controlled trial, 60 participants with RRMS suffering from fatigue were recruited and randomized equally to acupuncture (n = 30) and control (n = 30) groups. The acupuncture group received treatment 2 to 3 times per week for 10 sessions over 4 weeks. Both the acupuncture and control groups received amantadine 100 mg daily and routine treatment with immuno-modulators. The primary outcome was the fatigue severity scale (FSS) score, which was evaluated at baseline, and after 2 and 4 weeks. The secondary outcome was the Multiple Sclerosis Quality of Life 54 (MSQOL-54) questionnaire score, measured at baseline and the end of the 4-week treatment period. Results: The severity of fatigue was reduced in both groups. However, after 4 weeks of treatment, the reduction of fatigue in the acupuncture group was more significant than in the control group ( P < 0.01, mean difference (MD) = −1.14, 95% confidence interval (CI): −1.83 to −0.45). Quality of life, including mental and physical status, was significantly improved in the acupuncture group compared with the control group ( P < 0.05, MD = 9.09, 95% CI: 0.46 to 17.73). No adverse events occurred in any of the participants. Conclusions: Acupuncture combined with amantadine and routine care compared with amantadine and routine care alone appears to be an effective short-term treatment for reducing fatigue and enhancing quality of life, including physical function and mental status, in patients with RRMS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effectiveness of acupuncture for fatigue in patients with relapsing-remitting multiple sclerosis: a randomized controlled trial

et al. 2023

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“…Acupuncture is also widely used in symptom management of patients with Multiple Sclerosis (MS). Traditional Chinese acupuncture and scalp acupuncture can improve MS symptoms (fatigue, neural functional disorders, pain, gait disturbances, and bladder dysfunctions) and reduce attacks (level of evidence: moderate) 82 . Experimental studies on ischemic stroke explain the action mechanism of acupuncture in five different ways: promotion of cell proliferation in the central nervous system, regulation of cerebral blood flow through modulation of angiogenesis and vasoactive mediators, anti-apoptosis, regulation of neurochemicals, and strengthening and recovery of memory and learning processes 83 .…”

Section: Complementary and Alternative Therapies For Neurological Con...mentioning

confidence: 99%

Popular Complementary and Alternative Therapy Methods in Different Conditions

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Şavkın

et al. 2022

International Journal of Traditional and Complementary Medicine Research

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Complementary and alternative therapies (CAM) are methods for the prevention, diagnosis and treatment of diseases based on various cultural beliefs and experiences that are not currently considered part of modern medicine. In recent years, the integration of CAM applications into healthcare systems all over the world has led to an increase in their use and frequency, and it has also increased the necessity and expectation of evidence-based practices. In this review, it was aimed to examine the alternative treatment methods that are frequently used in different conditions, their mechanisms of action, and their application within the framework of scientific evidence. For this purpose, popularly used complementary and alternative therapies for musculoskeletal conditions (dry needling, instrument-assisted soft tissue mobilization, dry cupping), neurological conditions (acupuncture, reflexology), and other conditions such as cancer and metabolic diseases (yoga) were examined.

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“…Also, in this review, six studies monitoring the adverse effects of CHMs in MS treating showed that CHMs were well tolerated in all patients. In addition, acupuncture has been reported to be effective in reducing spasticity, pain, and numbness and improving fatigue, imbalance, and motor function in patients with DDC ( Criado et al, 2017 ; Khodaie et al, 2022 ). Nevertheless, it is worth noting that poor methodological quality, comparatively prominent clinical heterogeneity, and small sample size are common problems in most RCTs on TCM.…”

Section: Introductionmentioning

confidence: 99%

Demyelinating diseases of the central nervous system registry for patients with traditional Chinese medicine: Rationale and design of a prospective, multicenter, observational study

et al. 2022

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Background: Traditional Chinese medicine (TCM), a main form of complementary and alternative medicine provides a potential possibility for demyelinating disease of the central nervous system (DDC) management and has been applied in considerable amounts of patients with this disorder. Nevertheless, powerful real-world evidences regarding the epidemiological and clinical characteristics, safety, and outcomes of TCM in DDC are lacking. The primary objective of the Demyelinating Diseases of the Central Nervous System Registry for Patients with Traditional Chinese Medicine (DATE-TCM) is to create an organized multicenter data collection structure to define integrative characteristics of DDC patients treated with TCM in an endeavor to fill these knowledge gaps to better inform clinical care and health policy.Method: This study provides a prospective and voluntary registry by using a web-based system. Baseline data will be recorded and subsequently regular follow-up visits will be implemented every 3–6 months for a total of 5 years. The primary outcome is Annualized Aggregate Relapse Rate at 5-year follow-up.Results: DATE-TCM is currently designed to capture the multidimensional (epidemiologic, demographic, clinical, etc.) features of DDC patients receiving TCM treatment, the type and long-term safety and efficacy of TCM intervenes in the DDC populations, as well as the interaction of TCM treatments and disease modifying therapies in the management of DDC, aiming to include 2000 eligible adult DDC patients with TCM intervenes from 35 participating centers, covering 77.4% of provincial administrative regions of mainland China.Conclusion: DATE-TCM is the first, largest, most geographically extensive, and standard registry-based observational study that systematically document the real-world data regarding the TCM application in the DDC populations, which will be extraordinarily important for clarifying the comprehensive characteristics and outcomes of TCM in DDC, further shed light on standardizing and optimizing the TCM measures for DDC management and establishing evidence-based clinical practice guidelines for TCM application in DDC.

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Acupuncture for multiple sclerosis: A literature review

Cited by 11 publications

References 24 publications

Effectiveness of acupuncture for fatigue in patients with relapsing-remitting multiple sclerosis: a randomized controlled trial

Effectiveness of acupuncture for fatigue in patients with relapsing-remitting multiple sclerosis: a randomized controlled trial

Popular Complementary and Alternative Therapy Methods in Different Conditions

Demyelinating diseases of the central nervous system registry for patients with traditional Chinese medicine: Rationale and design of a prospective, multicenter, observational study

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