Acupuncture for neuropathic pain in adults

Ju, Zi Yong; Wang, Ke; Cui, Hua; Yao, Yibo; Liu, Shimin; Zhou, Jia; Chen, Tong Yu; Xia, Jun

doi:10.1002/14651858.cd012057

Cited by 28 publications

(30 citation statements)

References 76 publications

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“…Acupuncture is a popular technique in traditional Chinese medicine for various dysfunctions. 34,35 Its combined use with electrical output (EA) has been increasingly applied for the treatment of inflammatory pain. 31 EA stimulation at a frequency of 2/15 Hz is commonly used for the treatment of chronic pain.…”

Section: Discussionmentioning

confidence: 99%

<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

Huo

Zheng

Hua

et al. 2020

JPR

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These authors contributed equally to this workPurpose: Brain organisation is involved in the mechanism of neuropathic pain. Acupuncture is a common clinical practise in traditional Chinese medicine for the treatment of chronic pain. This study explored electroacupuncture's effects on brain metabolism following brachial plexus avulsion injury (BPAI)-induced pain. Methods: A total of 32 female rats were randomised into a normal group, model group, sham electroacupuncture group, and electroacupuncture group. A pain model was included via right BPAI. The electroacupuncture intervention at cervical "Jiaji" points (C5-7) was performed for 11 weeks. The mechanical withdrawal threshold of the non-injured (left) forepaw was measured at the baseline and on days 3, 7, 14, 21, 28, 56, 84, and 112 subsequent to BPAI. Positron emission tomography (PET) was applied to explore metabolic changes on days 28, 84, and 112. Results: After electroacupuncture, the mechanical withdrawal threshold of the left forepaws was significantly elevated and the effect persisted until 4 weeks after the intervention ceased (p<0.05 or p<0.001). In the sensorimotor-related brain regions, standardised uptake values in the bilateral somatosensory and motor cortices were observed in the electroacupuncture group. Metabolism particularly increased in the right somatosensory cortex. Metabolism changes also occurred in the pain-related brain regions and emotion-and cognition-related brain regions. Conclusion:The present study demonstrated the beneficial effects of electroacupuncture for relieving BPAI-induced neuropathic pain in rats. Electroacupuncture intervention might inhibit maladaptive plasticity in brain areas governing multidimensional functions, especially in sensorimotor-and cognition-related cortices.

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Section: Discussionmentioning

confidence: 99%

<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

Huo

Zheng

Hua

et al. 2020

JPR

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“…Pain and emotional disturbances are common symptoms during opioid withdrawal. Of note, auricular neural stimulation had been used for chronic pain management with success in various health settings (e.g., reviewed in (Chen et al 2018;Smith et al 2018;Ju et al 2017;Yeh et al 2014)). Episodic migraines, chronic tension headache, severe osteoarthritis of large joints have been the prime targets for acupuncture related nerve stimulation (Baraban et al 1995;Manheimer et al 2018;Linde et al 2016;MacPherson et al 2017).…”

Section: Transcutaneous Neural Stimulation As An Adjunct Treatment Fomentioning

confidence: 99%

Auricular neural stimulation as a new non-invasive treatment for opioid detoxification

et al. 2020

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The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are critically needed. The FDA has recently approved two non-invasive electrical nerve stimulators for the adjunct treatment of symptoms of acute opioid withdrawal. These devices, placed behind the ear, stimulate certain cranial nerves with auricular projections. This neural stimulation reportedly generates a prompt effect in terms of alleviation of withdrawal symptoms resulting from acute discontinuation of opioid use. Current experimental evidence indicates that this type of non-invasive neural stimulation has excellent potential to supplement medication assisted treatment in opioid detoxification with lower side effects and increased adherence to treatment. Here, we review current findings supporting the use of non-invasive neural stimulation in detoxification from opioid use. We briefly outline the neurophysiology underlying this approach of auricular electrical neural stimulation and its role in enhancing medication assisted treatment in treating symptoms of opioid withdrawal. Considering the growing deleterious impact of addictive disorders on our society, further studies on this emerging treatment modality are warranted.

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“…This was the case for the following drugs: nonsteroidal anti‐inflammatory drugs (NSAIDs), venlafaxine, nortriptyline, hydromorphone, oxycodone, morphine, fentanyl, tramadol, methadone, and cannabis . Robust evidence for transcutaneous electrical neurostimulation (TENS) and for acupuncture is also lacking . Multiple, good‐quality studies demonstrate superior efficacy of two‐drug combinations, but no recommendation can be made of any one specific drug combination …”

Section: Introductionmentioning

confidence: 99%

Should Pregabalin Be Used in the Management of Chronic Neuropathic Pain in Adults? A Cochrane Review Summary With Commentary

Kiekens¹

2019

PM&R

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Acupuncture for neuropathic pain in adults

Cited by 28 publications

References 76 publications

<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

Auricular neural stimulation as a new non-invasive treatment for opioid detoxification

Should Pregabalin Be Used in the Management of Chronic Neuropathic Pain in Adults? A Cochrane Review Summary With Commentary

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