Acupuncture for painful diabetic neuropathy

Kasuya, Daichi

doi:10.5692/clinicalneurol.52.1290

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, three studies were considered to have high selection bias, since two of the sequences were produced on the basis of admission ( 23 , 33 ), one is to adopt the method of non-probability sampling ( 43 ). The rest of the studies were rated as “unclear risk.” For the assessment of incomplete result data, 30 studies ( 16 – 42 , 46 , 47 , 49 ) were all rated “low risk” and six ( 43 – 45 , 48 , 50 , 51 ) were rated “unclear risk.”…”

Section: Resultsmentioning

confidence: 99%

“…Overall response rates were reported in 21 studies comparing the efficacy of acupuncture with MT for diabetic painful neuropathy ( 16 – 18 , 21 – 25 , 27 , 29 , 32 , 33 , 35 – 38 , 40 , 41 , 44 , 46 , 48 ). Outcomes of meta-analysis indicated that the overall efficacy of acupuncture was better than MT (RR = 1.42, 95%CI [1.34, 1.52], p < 0.00001; Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and safety of acupuncture for painful diabetic neuropathy: a systematic review and meta-analysis

Liu,

Lin,

Huang

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

BackgroundPainful diabetic neuropathy (PDN) is a common chronic neurological complication of diabetes mellitus. Medications are often used to relieve pain, but with significant side effects. Acupuncture is now a component of pragmatic and integrative treatment for PDN. An increasing number of relevant randomized controlled trials have been published in recent years, but a comprehensive meta-analysis has not yet been performed. The aim of this paper is to verify the effectiveness and safety of acupuncture for PDN by meta-analysis and trial sequential analysis (TSA).MethodsAll participants in this study should have had a PDN diagnosis and the trial group was treated with acupuncture. Eight databases, including EMbase, PubMed, Web of science, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), Wanfang and Chongqing VIP (CQVIP) were retrieved from inception to 5 April 2023. Meta-analysis was conducted utilizing RevMan 5.3 and Stata 15.0. TSA was performed to assess the adequacy of sample size for the outcomes.ResultsA total of 36 studies, comprising 2,739 PDN patients, were included. Among them, 1,393 patients were assigned to the trial group and 1,346 patients were treated in the control group. Outcomes covers the primary indicator Total effective rate (RR = 1.42, 95%CI [1.34, 1.52], p < 0.00001), with 21 studies reported, Pain intensity (SMD = −1.27, 95%CI [−1.58, −0.95], p < 0.00001), with 23 studies reported, and other outcomes, including motor nerve conduction velocity (MCV; MD = 3.58, 95%CI [2.77, 4.38], p < 0.00001), sensory nerve conduction velocity (SCV; MD = 3.62, 95%CI [2.75, 4.49], p < 0.00001), Depression score (SMD = −1.02, 95%CI [1.58, 0.46]), Toronto clinical scoring system (TCSS; MD = −2.41, 95%CI [−3.37, −1.45], p < 0.00001), Quality of life (SMD = 1.06, 95%CI [0.66, 1.46]), traditional Chinese medicine (TCM) syndrome score (MD = −4.99, 95%CI [−6.79, −3.18], p < 0.00001), suggesting that acupuncture have an ameliorating effect on PDN in various respect. Egger’s test revealed publication bias for four outcomes. TSA showed that as for Total effective rate, Pain Intensity, MCV and SCV, the number of included studies was sufficient to support the conclusions.ConclusionAcupuncture demonstrates significant effectiveness in improving PDN outcomes, including Total effective rate, Pain intensity, MCV, SCV, Depression score, TCSS, Quality of life, TCM syndrome score. But the Adverse events rate is no different in trail group and control group. The publication bias presented in Total effective rate, Pain intensity, MCV and SCV can be remedied by Trim and filling method.Systematic review registrationProspero, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=477295.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of acupuncture for painful diabetic neuropathy: a systematic review and meta-analysis

Liu,

Lin,

Huang

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…It is very effective for pain relief, especially for PDPN. A Japanese study showed that 20 patients with PDPN who received acupuncture treatment had better pain relief than the patients in the drug treatment group [ 39 ]. Another study confirmed that acupuncture can effectively improve the main symptoms of patients with PDPN, significantly reducing or even ending drug use [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Multimodal cerebral imaging study on the effects of “Adjust Zang Dredge Meridian” electroacupuncture on cerebral central sensitization in PDPN patients: a study protocol for a sham-controlled, randomized trial

Yao

Huang

et al. 2021

Trials

View full text Add to dashboard Cite

Background Painful diabetic peripheral neuropathy (PDPN) has a great impact on an individual’s quality of life. The current researchers’ previous trial suggested that acupuncture was a promising adjunctive treatment for PDPN. However, the underlying mechanism of action of acupuncture treatment for PDPN is still unclear, especially its effects at the cerebral level. The aim of this trial will be to explore how acupuncture works in treating PDPN by using multimodal cerebral imaging. Method and design This will be a randomized controlled trial. A total of 150 participants will be recruited and assigned to one of three groups: the healthy group, the DM without PDPN group and the DM with PDPN group. Participants in the DM without PDPN and the DM with PDPN groups will each be further divided between an electroacupuncture group and a sham electroacupuncture group. Participants will receive six treatment sessions per week for 4 weeks. Multimodal cerebral imaging includes resting-state functional magnetic resonance imaging (rs-fMRI), diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS); this neurophysiological testing will be the primary outcome measure. Subjective pain scales and blood analysis will be a secondary outcome measure and will be used to assess the clinical efficacy of the intervention. Multimodal cerebral imaging will be used to detect cerebral activity changes in each treatment group. The clinical data and fMRI data will be analysed for all the groups. Multiple correlation regression analyses will be used to assess the association between changes in cerebral functional activity and the improvement of clinical outcomes after acupuncture treatment. Discussion This study is based on the results of the researchers’ previous study, and using combined clinical and cerebral function changes, it will help evaluate the effects of acupuncture on PDPN. The investigation of acupuncture’s central mechanism of action will further expand the understanding of acupuncture treatment of PDPN. Trial registration Chinese Clinical Trial Registry ChiCTR1900024109. Registered on 26 June 2019.

show abstract

“…A different way to cure patients with diabetic polyneuropathy symptoms consists in alternative and complementary therapies, that, especially in Europe and the Far East, are more and more accepted as mainstream care [62], used alone or in association with standard pharmacological therapies. These modalities often include a variety of interventions such as use of magnet therapy, laser therapy and more than others, acupuncture [63,64]. This therapy is used to relieve pain, improve well being, and treat acute, chronic, and degenerative conditions in children and adults.…”

Section: Alternative Medicine In the Management Of Dpnmentioning

confidence: 99%

Use of Natural Compounds in the Management of Diabetic Peripheral Neuropathy

et al. 2014

View full text Add to dashboard Cite

Nephropathy, retinopathy cardiomyopathy and peripheral neuropathy are all recognized as important complications in about 50% of diabetes mellitus (DM) patients, mostly related to a poor glycemic control or to an improper management of this pathology. In any case, amongst others, diabetic peripheral neuropathy (DPN) seems the leading and most painful complication usually affecting many DM patients. For this reason, this work was conceived to review the large variety of strategies adopted for management of DPN, starting from the most conventional therapies to arrive at alternative approaches. From this perspective, both the most popular pharmacological treatments used to respond to the poorly effect of common analgesics-non-steroidal anti-inflammatory drugs (NSAIDS) and opioids-understood as gabapentin vs. pregabalin clinical use, and the guidelines provided by Oriental Medicine as well as by a long list of natural compounds that many authors identify as possible therapeutic or alternative agents to replace or to combine with the existing therapies will be included. Moreover, in the effort to provide the widest panel of remedies, the most antique techniques of acupuncture and electrostimulation will be considered as alternative, which are useful approaches to take into account in any non-pharmacological strategy for DPN management.

show abstract

Acupuncture for painful diabetic neuropathy

Cited by 4 publications

References 0 publications

Efficacy and safety of acupuncture for painful diabetic neuropathy: a systematic review and meta-analysis

Efficacy and safety of acupuncture for painful diabetic neuropathy: a systematic review and meta-analysis

Multimodal cerebral imaging study on the effects of “Adjust Zang Dredge Meridian” electroacupuncture on cerebral central sensitization in PDPN patients: a study protocol for a sham-controlled, randomized trial

Use of Natural Compounds in the Management of Diabetic Peripheral Neuropathy

Contact Info

Product

Resources

About