Acupuncture for radiation‐induced xerostomia in patients with cancer: A pilot study

Garcia, M. Kay; Chiang, Joseph S.; Cohen, Lorenzo; Liu, Meide; Palmer, J. Lynn; Rosenthal, David I.; Wei, Qi; Tung, S.; Wang, Congjun; Rahlfs, Thomas F.; Chambers, Mark S.

doi:10.1002/hed.21110

Cited by 55 publications

(32 citation statements)

References 47 publications

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“…Subjective and objective aspects of salivary function are improved with those technique. 189,190 In addition to this, hyperbaric oxygen in irradiated patients demonstrates increased salivary function 191 and reduction in the number of cariogenic bacteria and Candida albicans. Teguh et al 192 pointed out that hyperbaric oxygen favours neoangiogenesis and recruitment of bone marrow stem cells.…”

Section: Topical and Systemic Stimulantsmentioning

confidence: 98%

Salivary hypofunction: An update on aetiology, diagnosis and therapeutics

Saleh

Figueiredo

Cherubini

et al. 2015

Archives of Oral Biology

198

166

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Section: Topical and Systemic Stimulantsmentioning

confidence: 98%

Salivary hypofunction: An update on aetiology, diagnosis and therapeutics

Saleh

Figueiredo

Cherubini

et al. 2015

Archives of Oral Biology

198

166

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“…This problem is diffi cult to resolve as no 'gold standard' acupuncture protocol exists for treating xerostomia. 20 Furthermore, the personalised nature of the treatment given to each individual is considered a crucial component of care in traditional Chinese acupuncture and CAM. Skilled practitioners may therefore consider the introduction of any single 'gold standard' acupuncture protocol restrictive and counterproductive.…”

Section: Methodsmentioning

confidence: 99%

Clinical Effectiveness and Safety of Acupuncture in the Treatment of Irradiation-Induced Xerostomia in Patients with Head and Neck Cancer: A Systematic Review

O’Sullivan

Higginson

2010

Acupunct Med

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Background Irradiation-induced xerostomia seriously reduces quality of life for patients with head and neck cancer (HNC). Anecdotal evidence suggests that acupuncture may be beneficial. Objective To systematically review evidence on clinical effectiveness and safety of acupuncture in irradiation-induced xerostomia in patients with HNC. Methods A detailed search was performed to identify randomised controlled trials (RCTs) and systematic reviews of RCTs on acupuncture in irradiation-induced xerostomia, using AMED, BNIA, CINAHL, Cochrane, Embase, HPSI, PsycInfo and Medline. Grey literature was explored and 11 journals hand searched. Search terms included: acupuncture, xerostomia, salivary hypofunction, hyposalivation, dry mouth, radiotherapy, irradiation, brachytherapy, external beam. Two authors independently extracted data for analysis using predefined selection criteria and quality indicators. Results 43 of the 61 articles identified were excluded on title/abstract. 18 articles underwent full-text review; three were deemed eligible for inclusion. Two trials had moderate risk of bias; one had high risk. Two trials compared acupuncture with sham acupuncture; one control arm received ‘usual care’. Outcome measurements included salivary flow rates (SFRs) in two trials and subjective questionnaires in three. All three trials reported significant reduction in xerostomia versus baseline SFR (p<0.05); one reported greater effect in the intervention group for stimulated SFR (p<0.01). Subjective assessment reported significant differences between real acupuncture and control in two trials (p<0.02–0.05). Insufficient evidence was presented to undertake risk/benefit assessment. Conclusions Limited evidence suggests that acupuncture is beneficial for irradiation-induced xerostomia. Although current evidence is insufficient to recommend this intervention, it is sufficient to justify further studies. Highlighted methodological limitations must be dealt with.

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“…10 In that study, 19 patients with head and neck cancer who had postradiation xerostomia received acupuncture twice a week for 4 weeks. Significant subjective improvements were seen on xerostomia inventory (XI) and patient-benefit questionnaire (PBQ) scores after acupuncture at weeks 4 and 8, compared with baseline.…”

Section: Xerostomiamentioning

confidence: 99%