Acupuncture for the Treatment of Knee Osteoarthritis: An Overview of Systematic Reviews

Chen, Jixin; Liu, Aifeng; Zhou, Qinxin; Yu, Weijie; Guo, Tiantian; Jia, Yizhen; Yang, Kun; Niu, Puyu; Feng, Huichuan

doi:10.2147/ijgm.s342435

Cited by 18 publications

(16 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After treatment, the improvement degree of WOMAC score, TCM syndrome score, and VAS score in the observation group is better than that in the control group, which indicates that moxibustion instrument combined with intermediate frequency electrostatic therapy can effectively improve the joint function, clinical symptoms, and pain of patients. The moxibustion instrument can improve blood vessel permeability, activate collaterals, relieve pain through thermotherapy, phototherapy, drug stimulation, and acupoint stimulation, and finally improve knee joint function [ 17 ]. Intermediate frequency electrostatic therapy can promote cell metabolism, improve pain, enhance muscle strength, and improve joint function.…”

Section: Discussionmentioning

confidence: 99%

Effect of Moxibustion Instrument Combined with Intermediate Frequency Electrostatic Therapy on Pain and Joint Function in Elderly Patients with Cold-Dampness Knee Arthritis

Cui

Bai

2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Objective. To explore the effect of a moxibustion instrument combined with intermediate frequency electrostatic therapy on pain and joint function in elderly patients with cold-dampness arthritis (KOA). Method. 200 patients with cold-dampness KOA treated in our hospital from May 2019 to September 2021 were selected. According to the random number table method, they were divided into the observation group ( n = 100 ) and control group ( n = 100 ). The observation group was treated with moxibustion combined with medium-frequency treatment, and the control group was treated with medium-frequency treatment. The clinical effects of the two groups were compared. The joint functions of the two groups were evaluated by the visualization scale of the osteoarthritis index (WOMAC index) of McMaster University in Western Ontario. The TCM symptom scores of the two groups were evaluated according to the guiding principles for clinical research of new traditional Chinese medicine. The visual analogue scale (VAS) was used to evaluate the pain degree of the two groups, and the microcirculatory blood perfusion (MBPU) and interleukin-1 were compared between the two groups, β (IL-1β) and tumor necrosis factor-α (TNF-α). The levels of matrix metalloproteinase-1 (MMP-1), serum bone morphogenetic protein-2 (BMP-2), cartilage oligomeric matrix protein (COMP), and serum type II collagen C-terminal peptide (CTX-II) were assessed by the comprehensive quality of life questionnaire-74. Result. The total effective rate of the observation group (92.00%) was higher than that of the control group (76.00%), and the difference was statistically significant ( P < 0.05 ) in β and TNF-α. The levels of MMP-3, BMP-2, comp, and CTX-II and the improvement of quality of life score in the control group were better than those in the control group ( P < 0.05 ). Conclusion. Moxibustion instrument combined with intermediate frequency electrostatic therapy can effectively improve the knee joint function, pain, blood perfusion, inflammatory reaction, and cartilage damage of the elderly patients with cold-dampness-type knee arthritis, and the therapeutic effect is good.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Moxibustion Instrument Combined with Intermediate Frequency Electrostatic Therapy on Pain and Joint Function in Elderly Patients with Cold-Dampness Knee Arthritis

Cui

Bai

2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…As one of the most popular complementary and alternative treatments, 14 acupuncture has been used to treat osteoarthritis disorders in China since ancient times, and systematic reviews of Randomised Controlled Trials (RCTs) suggested benefits of acupuncture for KOA. 13 , 15 However, the central nervous mechanism of acupuncture in treating patients with KOA is not clear, which prevents its clinical application and further promotion.…”

Section: Introductionmentioning

confidence: 99%

Effect of Acupuncture on the Cognitive Control Network of Patients with Knee Osteoarthritis: Study Protocol for a Randomized Controlled Trial

Yin¹,

Zhang²,

Chang³

et al. 2022

JPR

View full text Add to dashboard Cite

Purpose Abnormal central nervous system function is the key central pathological factor leading to chronic pain in patients with knee osteoarthritis (KOA). Acupuncture can effectively relieve the pain of KOA patients. However, the central nervous mechanism of acupuncture treating KOA is not fully understood. This trial will use functional magnetic resonance imaging (fMRI) analysis techniques to investigate the potential central nervous mechanism of acupuncture treatment of KOA. Materials and Methods A total of 108 patients will be randomized (in a 1:1:1 ratio) into three groups, this trial will include 4-week treatment, patients in groups A and B will receive 20 acupuncture and sham acupuncture sessions, respectively, patients in group C will not receive any intervention, and all patients will receive fMRI scans before and after the intervention. The Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC) will be the primary clinical outcome. Then, we will explore the functional changes of the cognitive control network (CCN) in the brains of KOA patients through whole brain functional connectivity (FC) analysis and seed-based functional connectivity (sFC) analysis. Pearson correlation coefficient will be used to analyze the relationship between the improved value of the clinical correlation scale and the change of fMRI data. Discussion This trial will analyze the efficacy of verum acupuncture, sham acupuncture and the waiting-list for KOA and explore the activity of the CCN in three groups of patients by fMRI, so as to reveal the central nervous mechanisms of acupuncture in the treatment of KOA. Study Registration This study is approved by the Ethics Committee of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine (No: 2019HL-133-01) and registered in the Chinese Clinical Trial Registry, ChiCTR2000038554.

show abstract

“…Patients who meet any of the following criteria will be excluded from the trial: (1) are unable to walk; (2) have a serious infection of the knee; (3) have suspected tears in any ligaments or menisci or acute inflammation of the synovial capsule; (4) have a history of trauma, ligament damage, fracture, or surgery on the knee(s) within 6 months, causing pain or functional problems (history of knee replacement will be excluded); (5) have a history of local tumor/malignancy at the knee; (6) have physical or laboratory findings indicating infection, presence of autoimmune disease, or inflammatory arthritis; (7) have knee pain caused by radiculopathy/herniation of an intervertebral disc; (8) have end-stage diseases or other suspected severe conditions such as deep vein thrombosis of the lower limb, edema related to cancer or cancer treatment, severe blood coagulation disorders, uncontrolled systemic arterial hypertension, and severe diabetes; (9) have a history of prolotherapy, hyaluronic acid injections, or corticosteroid injections within 3 months; (10) have received acupuncture, electro-acupuncture, Tui-na therapy, massage, or physiotherapy 8 weeks prior to enrolment in the trial; (11) have severe pain in other regions; (12) have severe mental disorder(s); (13) are oversensitive to needles; and (14) are insensitive to pain due to advanced diabetes, neuropathy, or use of strong painkillers.…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…Considering the increasing burden of knee surgery and the side effects of conventional medications, an increasing number of patients with KOA are likely to choose complementary and alternative treatments [ 9 ]. As one of the most popular complementary and alternative treatments [ 10 ], acupuncture has been used to treat osteoarthritis disorders in China since ancient times [ 11 ], and systematic reviews of randomized controlled trials (RCTs) suggested the benefits of acupuncture for KOA [ 12 , 13 ]. Moreover, many guidelines for the diagnosis and treatment of KOA also recommend using acupuncture in the treatment of KOA [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of manual acupuncture, electro-acupuncture, and warm acupuncture for knee osteoarthritis: study protocol for a randomized controlled trial

Chang

Zhang

et al. 2022

Trials

View full text Add to dashboard Cite

Background Acupuncture is one of the most popular complementary and alternative treatments for knee osteoarthritis (KOA). There are many methods of acupuncture in the treatment of KOA, and the effects are different. According to our clinical observations and researches, it is found that manual acupuncture (MA), electro-acupuncture (EA), and warm acupuncture (WA) are used more frequently in the treatment of KOA, and the curative effects are satisfactory. However, there is currently a lack of efficacy comparison of efficacy between different acupuncture treatments, as well as a lack of standardized clinical research on the acupuncture treatment of KOA. Therefore, we will carry out a high-quality clinical randomized controlled trial to research the effect laws of MA, EA, and WA on KOA. Methods/design A total of 200 eligible participants with KOA will be randomly assigned to group A, B, C, or D in a ratio of 1:1:1:1. Patients in group A will receive MA, while those in group B, group C, and group D will be treated with EA, WA, and sham acupuncture (SA), respectively. Patients will be treated with acupuncture once a day, 30 min per session, 5 sessions per week for 4 weeks. The primary outcome is the change of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at week 4. The secondary outcomes include WOMAC, visual analog scale (VAS), Arthritis Quality of Life Measurement Scale Simplified Scale (AIMS2-SF), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Credibility/Expectancy Questionnaire. The evaluation will be performed at baseline and weeks 4, 8, and 12 respectively after randomization. Discussion This is a randomized controlled trial. We will observe the clinical effect of MA, EA, and WA on KOA to research the effect laws of these three acupuncture treatments on KOA and set up standardized treatment programs for acupuncture for KOA. Trial registration China Clinical Trials Registry ChiCTR2100049526. Registered on August 2, 2021

show abstract

Acupuncture for the Treatment of Knee Osteoarthritis: An Overview of Systematic Reviews

Cited by 18 publications

References 53 publications

Effect of Moxibustion Instrument Combined with Intermediate Frequency Electrostatic Therapy on Pain and Joint Function in Elderly Patients with Cold-Dampness Knee Arthritis

Effect of Moxibustion Instrument Combined with Intermediate Frequency Electrostatic Therapy on Pain and Joint Function in Elderly Patients with Cold-Dampness Knee Arthritis

Effect of Acupuncture on the Cognitive Control Network of Patients with Knee Osteoarthritis: Study Protocol for a Randomized Controlled Trial

Efficacy of manual acupuncture, electro-acupuncture, and warm acupuncture for knee osteoarthritis: study protocol for a randomized controlled trial

Contact Info

Product

Resources

About