Acupuncture for treating overactive bladder in adults

Hargreaves, Emma; Baker, Katherine; Barry, Gill; Harding, Christopher; Zhang, Yingying; Kandala, Ngianga Bakwin; Clarkson, C.

doi:10.1002/14651858.cd013519

Cited by 6 publications

(5 citation statements)

References 40 publications

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“… 36 OAB is a chronic disease mostly suffered by middle-aged and elderly females, and a longer treatment cycle should be developed according to TCM ideas. Hargreaves et al 37 considered that acupuncture for OAB was usually 1 session per week to achieve a course of 4–12 sessions, and acupuncture also has a continual therapeutic effect and may be more clinically relevant for long-term efficacy measurement. However, the current evidence in the literature remains inadequate concerning the specific duration of acupuncture treatment for OAB.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for Women with Overactive Bladder: Perspective of Traditional Chinese Medicine and Related Mechanism

Wang¹,

Lei²

2023

IJGM

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Purpose Overactive bladder (OAB) syndrome is one of the most common diseases in urology and affects quality of life. Although the current treatment for OAB is based on oral medications, there are limitations and many patients have difficulty accepting drug-induced adverse effects. This review aimed to analyze the efficacy of acupuncture and its related mechanisms and provide a preliminary therapeutic regimen. Methods Two authors independently searched PubMed, Embase, and Cochrane Library up to April 2022. They searched related English literature and extracted the data under a standard form based on the search strategy. Clinical trials which included OAB women with the treatment of acupuncture were included. Common acupuncture alone without other pharmacotherapy, external treatments was in the treatment group. The control interventions may include any active treatments, sham placebo, or no establishment of a control group. Outcomes included 3-day or 24-hour voiding diary, overactive bladder symptom score, etc. The Cochrane risk of bias tool was also used to assess the methodological quality of the randomized controlled trials (RCTs). Results We analyzed five RCTs and one comparative study on acupuncture for OAB to review and discuss the acupoint location, treatment course, and retention time based on clinical evidence and treatment ideas in traditional Chinese medicine. Additionally, we used the available evidence to reveal and discuss the acupuncture mechanisms for OAB. Acupuncture may regulate bladder function by inhibiting C-fibers, modulating nerve growth factors and reducing spontaneous contractions of the detrusor muscle. Conclusion Combined with the available evidence, the combination of local acupoints and distal acupoints should be necessary to consider, especially the lumbosacral acupoints, the small abdomen acupoints and the lower limb acupoints. Among them, acupuncture at SP4, CV4 and KI3 are strongly recommended. The treatment course of acupuncture should be no less than 4 weeks and maintain the frequency of acupuncture no less than once a week. The duration of each session should be no less than 20 minutes. In addition, investigations remain necessary to verify acupuncture’s efficacy and precise mechanism for OAB treatment in further exploration.

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Section: Discussionmentioning

confidence: 99%

Acupuncture for Women with Overactive Bladder: Perspective of Traditional Chinese Medicine and Related Mechanism

Wang¹,

Lei²

2023

IJGM

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“…Bladder smooth muscle activity is primarily in uenced by neurotransmitters [16], and β3 adrenoceptor agonists [17] have appeared as an emerging drug commonly used to treat incontinence, urgency, and frequency of urination caused by OAB. A study found that the effect of mirabegron on OAB symptoms is similar to that of solifenacin monotherapy, and it does not increase the risk of adverse events [18].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of the combination of transcutaneous tibial nerve stimulation(TTNS) and mirabegron in women with overactive bladder: a prospective randomized controlled trial

Xu,

Xiong,

Tian

et al. 2024

Preprint

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Objective: The management of overactive bladder (OAB) in women encompasses a range of strategies, from behavioral modifications to pharmacotherapy and nerve stimulation techniques. This prospective, randomized, controlled trial evaluates the efficacy of the combination of TTNS and mirabegron in symptom improvement over three months in women diagnosed with OAB. Patients and Methods: The study was designed as a randomized controlled trial. A total of 40 patients were prospectively randomized into two groups. Twenty patients in the combination group accepted TTNS and mirabegron therapy, and the other 20 patients as control only accepted mirabegron therapy. Primary outcomes were changes from baseline in the lower urinary tract symptoms. The severity of symptoms and quality of life (QoL) were assessed using the validated OAB questionnaire (OAB-q). Results: TTNS reduced the clinical symptoms of OAB, and the difference was statistically significant at all study sites (p<0.05). Regarding secondary outcomes, the OAB-q symptom bother score was lower in the combination group than in the mirabegron group (p<0.05). The OAB-q score in the combination group was statistically superior to that in the mirabegron group (p<0.05). The incidence of complications was not statistically significant between the two groups. Conclusion: The combination of TTNS and mirabegron represents a promising therapeutic strategy for women with overactive bladder, significantly improving symptoms and quality of life with a favorable safety profile. Further research with a larger sample size and long-term follow-up is warranted to confirm these findings and explore the underlying mechanisms of this combination therapy’s efficacy.

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“…Studies have shown that BT and combination therapies (BT with pharmacological treatment or PFME with biofeedback) decrease the frequency, urgency, and nocturia in women with urinary symptoms. However, combination therapies are found to be more effective 26–28 …”

Section: Introductionmentioning

confidence: 99%

Bladder training and Kegel exercises on urinary symptoms in female patients with multiple sclerosis

ÖZEN

Polat

2023

Int J of Uro Nursing

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This study was designed to determine the effects of bladder training and Kegel exercises on urinary symptoms and the quality of life in female patients with multiple sclerosis. A pretest‐posttest quasi‐experimental study was conducted. The study was composed of 37 participants from two different hospitals in Turkey. The data collection tools included a Patient Information Form, Expanded Disability Status Scale, Multiple Sclerosis Quality of Life Scale‐54, King's Health Questionnaire, and a bladder diary. Participants were followed through phone consultation seven times during a 3 month period. The participants showed a significant improvement in both the physical and mental health of their quality of life scores compared to the baseline regarding the King's Health Questionnaire Scale, there was an increase in patients' general health perception compared to the baseline. There was reduction in the frequency, nocturia, urgency, and urinary incontinence compared to the baseline at much level of symptoms odds. In this sample, bladder training and Kegel exercises improved quality of life in female patients with MS. These techniques increased the patients'general health perception of their urinary symptoms.

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Acupuncture for treating overactive bladder in adults

Abstract: This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To assess the e ects of acupuncture for treating OAB in adults; and summarise the principal findings of relevant economic evaluations.

Cited by 6 publications

References 40 publications

Acupuncture for Women with Overactive Bladder: Perspective of Traditional Chinese Medicine and Related Mechanism

Acupuncture for Women with Overactive Bladder: Perspective of Traditional Chinese Medicine and Related Mechanism

Efficacy of the combination of transcutaneous tibial nerve stimulation(TTNS) and mirabegron in women with overactive bladder: a prospective randomized controlled trial

Bladder training and Kegel exercises on urinary symptoms in female patients with multiple sclerosis

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