Acupuncture suppresses morphine self-administration through the GABA receptors

Yoon, Seong Shoon; Kim, Hongyu; Choi, Kwang-Dong; Lee, Bong Hyo; Lee, Yoon Kyoung; Lim, Sung Chul; Choi, Seong Hun; Hwang, Meeyul; Kim, Kwang Joong; Yang, Chae Ha

doi:10.1016/j.brainresbull.2009.12.011

Cited by 56 publications

(43 citation statements)

References 38 publications

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“…Their results suggest that the acupuncture effect on the morphine dependency is through the GABAergic system activation and recovering the dopamine depletion during the morphine withdrawal. 8,9 In addition, there are several lines of evidences indicating that the cupping reduces the pain conditions. 20 In this respect, the reductions in the pain scores are attributed to the sound rationale since the cupping therapy can elicit the release of the morphine-like substances (endorphins), and serotonin or cortisol that can ultimately lead to the pain relief and alter the physiological status of the individual.…”

Section: Discussionmentioning

confidence: 99%

“…Also results of another investigation have shown that acupuncture at the specific HT7 points through regulation of GABA receptors modulates the reinforcing effects of the morphine. 9 Ullah et al have reported that the acupuncture can stimulate the gates for pain in the CNS which interpret pain sensation, and also elicit the release of morphine like substances (endorphins), serotonin or cortisol which can ultimately lead to pain relief and alter the physiological status of the individual. 10 According to the literature, the principles of the acupuncture and the acupressure are very similar to that of the cupping therapy.…”

Section: Introductionmentioning

confidence: 99%

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Cupping: a reasonable choice for attenuating morphine withdrawal symptoms in Wistar rats

Khosravi

Roostayi

Manshadi

et al. 2017

Int J Basic Clin Pharmacol

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Background: Nowadays, the sedative drugs are the main treatments to attenuate the opioid withdrawal symptoms. However, physical therapies are found a safe alternative treatment without any serious adverse effects. This study aimed to evaluate the effects of cupping treatment on the morphine withdrawal symptoms in rats.Methods: Eighty rats were divided into two main groups; treated with morphine or saline, and each group was also divided to cupping and sham cupping subgroups (with single or daily treatment). Injection of morphine and saline were done in the morphine and saline groups twice a day for nine days. On the ninth day, the naloxone was administered and the withdrawal symptoms including jumping, rearing, body grooming, abdominal writing, and wet-dog shaking were recorded for 60 minutes. Cupping or sham cupping was applied on the GV14 once before or daily after withdrawal induction in each group.Results: The results revealed that a single cupping before the withdrawal induction significantly attenuated the withdrawal symptoms in the morphine group (p<0.01).But, the daily cupping failed to decrease the withdrawal symptoms in this group. The results also indicated that the daily cupping in the saline group increased the naloxone-induced withdrawal symptoms significantly (p<0.01).Conclusions: Single session cupping before the withdrawal induction could decreased the withdrawal symptoms. This finding might be related to the modulation of GABAergic system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cupping: a reasonable choice for attenuating morphine withdrawal symptoms in Wistar rats

Khosravi

Roostayi

Manshadi

et al. 2017

Int J Basic Clin Pharmacol

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“…Acupuncture, which is one of the most popular and widely used nondrug interventions in CAM, may affect brain neurotransmitters including GABA (Yoon et al 2010) and glutamate (Lee et al 2010) and the pathogenic factors of ASD (Cheuk et al 2011). The possible mechanism by which music therapy affects autism has been suggested to be related to the improvement of communication through nonverbal components of language, including rhythm, pulse, and tempo, as infants first learn language from their mothers Trevarthen 1999).…”

Section: Possible Mechanismmentioning

confidence: 99%

Complementary and Alternative Medicine for Autism

Lee¹,

Choi²,

Ernst³

2014

Comprehensive Guide to Autism

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“…In addition, many studies assessing the effects of acupuncture on morphine revealed a relation with the gamma aminobutyric acid (GABA) system [7,15,19,20]. Therefore, we also investigated the possible neuronal mechanism in the effects of acupuncture, focusing on the GABA pathway.…”

Section: Introductionmentioning

confidence: 98%

“…Most of all, acupuncture has shown to suppress morphine self-administration [15]. In particular, our previous studies demonstrated that acupuncture at SI5 reduced morphineseeking behavior following abstinence [16,17].…”

Section: Introductionmentioning

confidence: 99%

Acupuncture Suppresses Morphine Craving in Progressive Ratio Through the GABA System

Lee

Zhao

Lee

et al. 2015

Journal of Acupuncture and Meridian Studies

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Previous studies revealed that acupuncture suppressed both morphine self-administration and morphine-seeking behavior after abstinence. Based on these results, this study examined whether acupuncture attenuated morphine-craving under a progressive ratio (PR) schedule and investigated the possible neuronal mechanism. Male Sprague-Dawley rats were trained to self-administer morphine (0.5 mg/kg) at a fixed ratio for 9 days, and rats who achieved stable infusion were switched to a PR schedule. When animals had taken no more morphine for 1 hour, the number of infusions was defined as the break point (BP). After PR training, animals that had established a stable BP received acupuncture the next day. Acupuncture was applied for 1 minute immediately before the test session. Bicuculline (1.0 mg/kg) and SCH 50911 (2.0 mg/kg) were given 30 minutes prior to acupuncture. The c-Fos levels in the ventral tegmental area (VTA) and the nucleus accumbens (NAc) were examined. Acupuncture at SI5 reduced the BP significantly. Moreover, the effects of acupuncture were blocked by either bicuculline or SCH 50911. Immunofluorescence revealed that acupuncture at SI5 decreased c-Fos expressions in the VTA and the NAc. This study demonstrates that acupuncture at SI5 is effective for the treatment of morphine-craving and that this effect is mediated via the GABA pathway.

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Acupuncture suppresses morphine self-administration through the GABA receptors

Cited by 56 publications

References 38 publications

Cupping: a reasonable choice for attenuating morphine withdrawal symptoms in Wistar rats

Cupping: a reasonable choice for attenuating morphine withdrawal symptoms in Wistar rats

Complementary and Alternative Medicine for Autism

Acupuncture Suppresses Morphine Craving in Progressive Ratio Through the GABA System

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