Acupuncture to Danzhong but not to Zhongting increases the cardiac vagal component of heart rate variability

Kurono, Yukihisa; Minagawa, Munenori; Ishigami, Tatsuyo; Yamada, Atsushi; Kakamu, Toshinori; Hayano, Junichiro

doi:10.1016/j.autneu.2010.12.003

Cited by 38 publications

(24 citation statements)

References 14 publications

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“…EA could result in modulation of the neuronal nitric oxide synthase activity in the hypothalamus to regulate sympathetic outflow in spontaneously hypertensive rats (19). EA could also modulate cardiac autonomic imbalance by increasing the cardiac vagal component of heart rate variability (15,22). There are studies reporting that vagal nerve stimulation markedly improved the longterm survival of CHF rats through the prevention of pumping failure and cardiac remodeling (26,50).…”

Section: Discussionmentioning

confidence: 96%

Electroacupuncture improves cardiac function and remodeling by inhibition of sympathoexcitation in chronic heart failure rats

Cui

Shao

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

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Chronic heart failure (CHF) is responsible for significant morbidity and mortality worldwide, mainly as a result of neurohumoral activation. Acupuncture has been used to treat a wide range of diseases and conditions. In this study, we investigated the effects of electroacupuncture (EA) on the sympathetic nerve activity, heart function, and remodeling in CHF rats after ligation of the left anterior descending coronary artery. CHF rats were randomly selected to EA and control groups for acute and chronic experiments. In the acute experiment, both the renal sympathetic nerve activity and cardiac sympathetic afferent reflex elicited by epicardial application of capsaicin were recorded. In the chronic experiment, we performed EA for 30 min once a day for 1 wk to test the long-term EA effects on heart function, remodeling, as well as infarct size in CHF rats. The results show EA significantly decreased the renal sympathetic nerve activity effectively, inhibited cardiac sympathetic afferent reflex, and lowered the blood pressure of CHF rats. Treating CHF rats with EA for 1 wk dramatically increased left ventricular ejection fraction and left ventricular fraction shortening, reversed the enlargement of left ventricular end-systolic dimension and left ventricular end-diastolic dimension, and shrunk the infarct size. In this experiment, we demonstrated EA attenuates sympathetic overactivity. Additionally, long-term EA improves cardiac function and remodeling and reduces infarct size in CHF rats. EA is a novel and potentially useful therapy for treating CHF.

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Section: Discussionmentioning

confidence: 96%

Electroacupuncture improves cardiac function and remodeling by inhibition of sympathoexcitation in chronic heart failure rats

Cui

Shao

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

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“…Previous studies have revealed that acupuncture at the Sishencong points and Qi-training enhanced cardiac vagal and suppressed sympathetic activities in humans [22, 23]. In a recent study, epifascial acupunctural stimulation at CV17 also increased vagal activity, and the presence of a specific acupunctural point that causes the modulation of cardiac autonomic function is suggested [24]. …”

Section: Discussionmentioning

confidence: 98%

Autonomic Conditions in Tinnitus and Implications for Korean Medicine

Choi

Yun

Yoo

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Tinnitus patients suffer from not only auditory sensations but also physical, mental, and social difficulties. Even though tinnitus is believed to be associated with the autonomic nervous system, changes in autonomic conditions in tinnitus patients are not receiving much research attention. The aims of this study were to investigate the autonomic condition of tinnitus patients and to consider Korean medicine in the treatment of tinnitus with an evidence-based approach. We performed a retrospective chart review and compared the heart rate variability (HRV) parameters of 40 tinnitus patients (19 acute and 21 chronic) and 40 healthy controls. In tinnitus patients, the power of the high frequency component and total power of the HRV significantly decreased (P < 0.05), and the low frequency to high frequency ratio significantly increased (P < 0.05). There was no significant difference between the acute and chronic patients. When comparing each group with the controls, there was a tendency that the longer the duration of tinnitus was, the larger the observed HRV change was. In conclusion, tinnitus patients have vagal withdrawal and sympathetic overactivity, and chronic tinnitus more strongly affects autonomic conditions than acute tinnitus. This study provides evidence for Korean medical treatments of tinnitus, such as acupuncture and Qi-training, that cause modulation of cardiac autonomic function.

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“…On the other hand, what degree does it affect the autonomic nerve is still unknown. It was concluded that at least a part of the effects of acupuncture was independent of the presence of a deqi sensation [34]. In this trial, we will compare the impact of needling at two different depths by HRV analysis and discuss the relationship of deqi phenomenon and acupuncture effect from the view of autonomic modulation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Deqi on Autonomic Balance in Adult Tinnitus Patients: Study Design of a Randomized Controlled Trial

Shi

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Background. Recent reports suggest that a proportion of tinnitus patients suffer from mental illness. Autonomic nervous system plays a useful role in tinnitus therapy since electrical vagal nerve stimulation (VNS) has been frequently used to alleviate tinnitus-induced depression in clinic. heart rate variability (HRV), which is reflective of autonomic nervous system function, has been proved to be modulated by acupuncture. In the present study, we aim to compare the effect of deqi sensation on heart rate variability in adult tinnitus patients. Methods. Thirty participants are randomly assigned to verum acupuncture (creating deqi) or shallow acupuncture (not creating deqi) at Baihui (Du-20), Shenting (Du-24), Tinghui (GB-2), Waiguan (SJ-5), and Zulinqi (GB-41) for 3 weeks. The primary outcome measure is heart rate variability, which is measured at the first acupuncture, as well as the last acupuncture. Discussion. Completion of this trial will help to identify the role of deqi sensation in acupuncture effect for tinnitus and reveal an autonomic modulation mechanism for acupuncture effect. Trial Registration. This trial is registered with International Standard Randomised Controlled Trial Number ISRCTN58013563.

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Acupuncture to Danzhong but not to Zhongting increases the cardiac vagal component of heart rate variability

Cited by 38 publications

References 14 publications

Electroacupuncture improves cardiac function and remodeling by inhibition of sympathoexcitation in chronic heart failure rats

Electroacupuncture improves cardiac function and remodeling by inhibition of sympathoexcitation in chronic heart failure rats

Autonomic Conditions in Tinnitus and Implications for Korean Medicine

Effects of Deqi on Autonomic Balance in Adult Tinnitus Patients: Study Design of a Randomized Controlled Trial

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