Acupuncture to Promote Recovery of Disorder of Consciousness after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Tan, Li; Zeng, Liling; Wang, Ning; Deng, Meijun; Chen, Yinshi; Ma, Tianyi; Zhang, Luhan; Xu, Zhenhua

doi:10.1155/2019/5190515

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…Significant higher efficiency in disorders of consciousness treatment following traumatic brain injury was found with the acupuncture group as compared to that with the control. 77 The World Health Organization has reported that acupuncture can be used to effectively treat 31 symptoms including cardiac pain, hypertension and arrhythmias. 78 Many studies revealed the therapeutic efficacy in hypertension, hypotension, arrhythmias, angina pectoris and myocardial infarction with the emphasis on acupoints Neiguan (PC 6) and Zusanli (E 36).…”

Section: Acupuncturementioning

confidence: 99%

<p>Traditional Chinese Medicine in Emergency Treatment Mechanism and Application</p>

Meng¹,

Michelena²,

Cai³

et al. 2020

OAEM

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Traditional Chinese medicine has usually been recognized to be efficacious to treat chronic diseases from the western point-of-view. However, there is a long history in China of applying traditional Chinese medicine in many acute and urgent medical conditions. In this review, selected methods documented in traditional Chinese medicine including blowing air to ear, nose insufflating therapy, acupuncture and moxibustion were presented as the common practices to promote consciousness recovery from coma. We aimed to explore the mechanism of these four methods with current scientific evidence, further discuss the potential of traditional Chinese medicine to be applied in emergency medicine and provide a path forward to more rigorously validate these procedures. The development of the integrated traditional Chinese medicine and western medicines provides a new therapeutic direction for the new first-aid treatment.

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Section: Acupuncturementioning

confidence: 99%

<p>Traditional Chinese Medicine in Emergency Treatment Mechanism and Application</p>

Meng¹,

Michelena²,

Cai³

et al. 2020

OAEM

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“…[15] Few studies have investigated acupuncture as an adjuvant therapy in the acute phase of TBI (within 2 weeks after injury), which high-quality randomized controlled trials (RCTs) are particularly lacking. [16] For this reason, and taking into account the preliminary results of the previous trials, a standardized RCT is planned to assess the effect of acupuncture on the prognosis of patients with TBE. The method of monitoring and quantitatively analyzing brain edema based on head computed tomography (CT) can be very convincing, and complementary acupuncture treatment in the acute-phase TBI (starting within 72 hours after injury) can be a novel idea of designing in this clinical trial.…”

Section: Introductionmentioning

confidence: 99%

“…Even though the acupuncture has been observed to be an effective treatment for patients with TBI, some of the acupuncture data remain weak and unconvincing [15] . Few studies have investigated acupuncture as an adjuvant therapy in the acute phase of TBI (within 2 weeks after injury), which high-quality randomized controlled trials (RCTs) are particularly lacking [16] . For this reason, and taking into account the preliminary results of the previous trials, a standardized RCT is planned to assess the effect of acupuncture on the prognosis of patients with TBE.…”

Section: Introductionmentioning

confidence: 99%

Early complementary acupuncture improves the clinical prognosis of traumatic brain edema

Guo

Jiang²,

Huang

et al. 2022

Medicine

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Background: Traumatic brain edema occurs commonly brain injury, and most manifests as pericontusional edema of brain contusions. On the basis of evidence-based medicine, apart from recommending craniotomy and mannitol, there are few particularly effective measures to prevent and treat traumatic brain edema. It is uncertain whether an early complementary acupuncture treatment would improve long-term outcomes of patients with traumatic brain edema. The aim of this study is to assess the efficacy and the safety of early complementary acupuncture for patients with traumatic brain edema.Methods: This study is an actively accruing, single-center, single-blinded, 2-arm, randomized controlled trial. Patients with traumatic brain injury, a Glasgow Coma Scale score of 6∼12, and brain edema on computed tomography scan will be divided into 2 groups on the basis of stratified block randomization. All patients will receive conventional treatment, and the study group will undergo additional acupuncture therapy (start within 72 hours after the injury) once a day for 28 days. The primary outcome is the dichotomized Glasgow Outcome Score at 6 months and 12 months after injury, and the secondary outcomes are the Glasgow Coma Scale, the volume of traumatic brain edema, the serum levels of C-reactive protein and interleukin-6, and the Modified Barthel Index.Discussion: This study will provide data regarding the efficacy of early complementary acupuncture for traumatic brain edema. If the study yields positive results, its findings may offer insights into a valuable complementary option of acupuncture for traumatic brain edema that could provide pilot evidence for large, randomized, controlled trials.Trial registration: This trial has been published in the Chinese Clinical Trial Register, http://www.chictr.org.cn/edit.aspx?pid= 141208&htm=4 (Identifier: ChiCTR2100053794, registered on December 3, 2021).Abbreviations: CRFs = case report forms, CRP = C-reactive protein, CT = computed tomography, GCS = Glasgow Coma Scale, GOS = Glasgow Outcome Score, ICP = intracranial pressure, IL-6 = interleukin-6, MBI = Modified Barthel Index, RCT = randomized clinical trial, TBE = traumatic brain edema, TBI = traumatic brain injury.

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“…Therefore, there is urgent need for effective, simple, and safe methods to promote awakening from an unconscious state. Our previous meta-analysis [ 20 ] showed that acupuncture fared well in the treatment of TBI-induced DOC in which “shuigou (DU 26)” was the most important and frequent point targeted. As such, acupuncture has been shown to be an effective therapy for TBI.…”

Section: Introductionmentioning

confidence: 99%

Arousing Effects of Electroacupuncture on the “Shuigou Point” in Rats with Disorder of Consciousness after Traumatic Brain Injury

Tan

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

Self Cite

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Orexin is an important neuropeptide that stimulates cortical activation and arousal and is involved in the regulation of wakefulness and arousal. Our previous meta-analysis showed that acupuncture fared well in the treatment of TBI-induced DOC in which “shuigou (DU 26)” was the most important and frequent point targeted. In the present study, we investigated whether electroacupuncture (EA) promotes TBI-induced unconsciousness wakefulness via orexin pathway. A TBI rat model was established using a control cortical impact (CCI) model. In the stimulated group, TBI rats received EA (15 Hz, 1.0 mA, 15 min). In the antagonist group, TBI rats were intraperitoneally injected with the orexin receptor 1 (OX1R) antagonist SB334867 and received EA. Unconsciousness time was observed in each group after TBI, and electrocorticography (ECoG) was applied to detect rats’ EEG activity. Immunohistochemistry, enzyme-linked immunosorbent assay, and western blot were used to assess the levels of orexin-1(OX1) and OX1R expression in the mPFC. We show that duration of unconsciousness and the ratio of delta power in ECoG in the EA group were significantly reduced compared with those in the TBI group. EA could increase OX1 and OX1R expression in the mPFC and reduced the loss of orexin-producing neurons in LHA. However, all the efficacy of EA was blocked by the OX1R antagonist SB334867. Our findings suggest that EA promotes the recovery of consciousness of TBI-induced unconscious rats via upregulation of OX1and OX1R expression in mPFC.

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Acupuncture to Promote Recovery of Disorder of Consciousness after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Cited by 15 publications

References 28 publications

<p>Traditional Chinese Medicine in Emergency Treatment Mechanism and Application</p>

<p>Traditional Chinese Medicine in Emergency Treatment Mechanism and Application</p>

Early complementary acupuncture improves the clinical prognosis of traumatic brain edema

Arousing Effects of Electroacupuncture on the “Shuigou Point” in Rats with Disorder of Consciousness after Traumatic Brain Injury

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