Acupuncture treatment of patients with radiation-induced xerostomia

Blom, Marja; Dawidson, I; Fernberg, Jan-Olof; Johnson, Glen H.; Angmar‐Månsson, Birgit

doi:10.1016/0964-1955(95)00085-2

Cited by 149 publications

(175 citation statements)

References 12 publications

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“…However, only in 2 studies 33,34 was random assignment implemented via a secure computerized database, ensuring full concealment of allocation. Double blinding was described in 1 trial, 31 and neither the examiner nor the patients knew whether acupuncture or placebo acupuncture had been given in this study.…”

Section: Results Of Methodological Quality Assessmentmentioning

confidence: 99%

“…Two included RCTs used salivary flow rates as objective outcome measures. Blom et al 31 reported that in the acupuncture group 68% and in the control group 50% of the patients had increased salivary flow rates at the end of the 1-year observation period. Significant differences of salivary flow rates between pretreatment and posttreatment could be observed within each group, but there were no statistically significant differences between acupuncture and control groups.…”

Section: Efficacy and Safety Of Acupuncture For Radiation-induced Xermentioning

confidence: 99%

“…Blom et al 31 reported the alleviation of symptoms, leading to a better quality of life, but without quantitative data. The questionnaire used by Cho et al 32 consisted of 4 questions addressing problems in communicating, eating, sleeping, and daily functions.…”

Section: Efficacy and Safety Of Acupuncture For Radiation-induced Xermentioning

confidence: 99%

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The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

et al. 2012

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Background. Methods currently available to prevent and manage xerostomia which caused by radiotherapy in patients with head and neck caner have limited efficacy. Some studies suggest that acupuncture may be beneficial. Objectives. The authors evaluated the preventive and therapeutic effect of acupuncture for radiation-induced xerostomia among patients with head and neck cancer. Methods. PUBMED, EMBASE, Cochrane Library, CBM, CAJD, Wan Fang database, and VIP Database for Chinese Technical Periodicals were electronically searched, in conjunction with further manual search for relevant articles. Studies that met the inclusion criteria were systematically evaluated. Results. Three randomized controlled trials (RCTs) investigating the therapeutic effect of acupuncture were included. One RCT on the preventive effect of acupuncture was found. Because of the considerable variation among included studies, meta-analysis was not possible. Two included RCTs used placebo controls, and both observed significant improvement in the salivary flow rates between acupuncture and control groups. However, no significant differences were found. Three included RCTs suggested that acupuncture for radiation-induced xerostomia can improve patients' subjective symptoms. The only study evaluating the preventive effect of acupuncture for radiation-induced xerostomia showed positive changes in salivary flow rates (both unstimulated and stimulated) and dry mouth -related symptoms. Acupuncture treatment was well tolerated by all patients and no severe adverse effects were seen. Conclusions. Insufficient evidence is available to judge whether acupuncture is safe and whether it is effective in preventing or treating radiation-induced xerostomia. Significant research remains to be done before acupuncture can be recommended for routine use in radiation-induced xerostomia.

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Section: Results Of Methodological Quality Assessmentmentioning

confidence: 99%

Section: Efficacy and Safety Of Acupuncture For Radiation-induced Xermentioning

confidence: 99%

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The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

et al. 2012

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“…when meta-analysis of randomized control trial of pilocarpine was done by schuller et al, the overall improvement in condition of xerostomia was superior with pilocarpine. Hence, pilocarpine is superior to other novel agents [27]. Curative treatment needs proper diagnosis of underlying pathology for hyposalivation which includes sialometry, sialochemistry, salivary gland imaging, etc.…”

Section: Mucositis and Stomatitismentioning

confidence: 99%

Palliative Dental Care- A Boon for Debilitating

Mulk

Chintamaneni

Prabhat

et al. 2014

JCDR

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“…A RCT involving 38 patients with radiation xerostomia was reported from the Karolinska Institute in Sweden 283 . Subjects were randomized to either deep acupuncture treatment or superficial acupuncture treatment.…”

Section: Acupuncturementioning

confidence: 99%

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

Sagar

Wong

2008

Current Oncology

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Traditional Chinese Medicine (TCM) is a whole system containing therapeutic interventions that individually induce biomodulation at the physiologic, chemical, and molecular levels. The theory of TCM proposes a synergy between specific interventions selected as part of a care plan based on TCM diagnostic theory. Combining TCM with the modern practice of oncology seems, in conjunction with biomedical interventions (surgery, radiotherapy, chemotherapy, and pharmaceuticals), to have potential advantages through the synergy of biomodulation. Biomodulation approaches are broadly categorized as modification of tumour response and reduction of adverse effects; modulation of immunity; prevention of cancer progression; and enhancement of symptom control. Although the database of preclinical studies is rapidly expanding, good-quality clinical trials are notably scarce.Laboratory studies suggest that some herbs increase the effectiveness of conventional chemotherapy without increasing toxicity. A healthy immune system is necessary for control of malignant disease, and the immune suppression associated with cancer contributes to its progression. Many Chinese herbs contain glycoproteins and polysaccharides (among them, constituents of Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Astragalus membranaceus, Panax ginseng, and various other medicinal mushrooms) that can modulate metastatic potential and the innate immune system. Phytochemicals such as specific polysaccharides have been shown to boost the innate immune system, especially through interaction with Tolllike receptors in mucosa-associated lymphoid tissue. This intervention can potentially improve the effectiveness of new anticancer vaccines. An increase in virusassociated cancers presents a major public health problem that requires novel therapeutic strategies. A number of herbal therapies have both antiviral activity and the ability to promote immunity, possibly inhibiting the initiation and promotion of virus-associated cancers.The mechanisms learned from basic science should be applied to clinical trials both of specific interventions and of whole-system care plans that safely combine the TCM approach with the conventional biomedical model. In Western medicine, the combination of TCM herbs with drug therapies is controversial, given lack of knowledge concerning whether a drug is favourably enhanced or whether adverse effects occur. Using initial data from the preclinical studies, future clinical research needs to evaluate the combinations, some of which are showing favourable synergy.

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Acupuncture treatment of patients with radiation-induced xerostomia

Cited by 149 publications

References 12 publications

The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

Palliative Dental Care- A Boon for Debilitating

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

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