Acute administration of a cannabinoid CB1 receptor antagonist impairs stress-induced antinociception in fish

Wolkers, Carla Patrícia Bejo; Barbosa, Artur Felipe Santos; Menescal-de-Oliveira, Leda; Hoffmann, Anette

doi:10.1016/j.physbeh.2015.01.038

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…These results have been extended by reports demonstrating that analgesia occurring after exposure to the context of footshock similarly involves an eCB mechanism in the periaqueductal gray (Olango et al, 2012). More so, these results have been extended by other reports that global disruption of CB1 receptor signaling block stress-induced analgesia (Kurrikoff et al, 2008), as well as a recent report that eCB signaling similarly mediates stress-induced analgesia in fish (Wolkers et al, 2015). As such, there seems to be substantial evidence that stress-induced increases in eCB signaling mediate the acute analgesic effect that occurs after exposure to stress.…”

Section: Functional Role Of Ecb Signaling In the Neurobiological Effesupporting

confidence: 59%

Neurobiological Interactions Between Stress and the Endocannabinoid System

Morena

Patel

Bains

et al. 2015

Neuropsychopharmacol

512

496

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Stress affects a constellation of physiological systems in the body and evokes a rapid shift in many neurobehavioral processes. A growing body of work indicates that the endocannabinoid (eCB) system is an integral regulator of the stress response. In the current review, we discuss the evidence to date that demonstrates stress-induced regulation of eCB signaling and the consequential role changes in eCB signaling have with respect to many of the effects of stress. Across a wide array of stress paradigms, studies have generally shown that stress evokes bidirectional changes in the two eCB molecules, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), with stress exposure reducing AEA levels and increasing 2-AG levels. Additionally, in almost every brain region examined, exposure to chronic stress reliably causes a downregulation or loss of cannabinoid type 1 (CB1) receptors. With respect to the functional role of changes in eCB signaling during stress, studies have demonstrated that the decline in AEA appears to contribute to the manifestation of the stress response, including activation of the hypothalamic-pituitary-adrenal (HPA) axis and increases in anxiety behavior, while the increased 2-AG signaling contributes to termination and adaptation of the HPA axis, as well as potentially contributing to changes in pain perception, memory and synaptic plasticity. More so, translational studies have shown that eCB signaling in humans regulates many of the same domains and appears to be a critical component of stress regulation, and impairments in this system may be involved in the vulnerability to stress-related psychiatric conditions, such as depression and posttraumatic stress disorder. Collectively, these data create a compelling argument that eCB signaling is an important regulatory system in the brain that largely functions to buffer against many of the effects of stress and that dynamic changes in this system contribute to different aspects of the stress response.

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Section: Functional Role Of Ecb Signaling In the Neurobiological Effesupporting

confidence: 59%

Neurobiological Interactions Between Stress and the Endocannabinoid System

Morena

Patel

Bains

et al. 2015

Neuropsychopharmacol

512

496

View full text Add to dashboard Cite

show abstract

“…AA-5-HT. This finding is in line with our previous studies, where CB1 blockade with AM-251 barely reduced the anti-allodynic effect caused by another FAAH inhibitor [75], and might be due in part to the previously reported anti-nociceptive and antiinflammatory effects of CB1 antagonists [80,84], although we used a per se inactive dose of AM-251.…”

Section: Discussionsupporting

confidence: 93%

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

Małek

Kostrzewa

Makuch

et al. 2016

Pharmacological Research

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“…Activation of the anandamide/CB 1 / PI3K pathway was recently reported to protect rat brains from cocaine-induced neurotoxicity (Vilela et al, 2015). Some evidence indicates that pharmacological manipulation of the cannabinoid system can alleviate symptoms of several conditions, including addiction, seizures, neurodegenerative disease, and nociception (Adamczyk et al, 2009;Almeida-Santos et al, 2013;Pietropaolo et al, 2015;Vilela et al, 2015;Wolkers et al, 2015). For example, treatment with a CB 1 receptor agonist, WIN 55,212-2 [(R)-(1)-[2,3-dihydro-5methyl-3-4-morpholinylmethyl)pyrrolo[1,2,3,-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate], prevented the appearance of motor deficits, decreased the number of striatal huntingtin inclusions, and rescued striatal medium-sized spiny neurons loss in a Huntington disease mouse model (Pietropaolo et al, 2015).…”

Section: Cb 1 Receptor: Pharmacology and Cell Signaling Pathwaysmentioning

confidence: 99%

Dissecting the Signaling Pathways Involved in the Crosstalk between Metabotropic Glutamate 5 and Cannabinoid Type 1 Receptors

2016

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The metabotropic glutamate 5 receptor and the cannabinoid type 1 receptor are G protein-coupled receptors that are widely expressed in the central nervous system. Metabotropic glutamate 5 receptors, present at the postsynaptic site, are coupled to Gα proteins and display an excitatory response upon activation, whereas the cannabinoid type 1 receptor, mainly present at presynaptic terminals, is coupled to the G protein and triggers an inhibitory response. Recent studies suggest that the glutamatergic and endocannabinoid systems exhibit a functional interaction to modulate several neural processes. In this review, we discuss possible mechanisms involved in this crosstalk and its relationship with physiologic and pathologic conditions, including nociception, addiction, and fragile X syndrome.

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Acute administration of a cannabinoid CB1 receptor antagonist impairs stress-induced antinociception in fish

Cited by 13 publications

References 36 publications

Neurobiological Interactions Between Stress and the Endocannabinoid System

Neurobiological Interactions Between Stress and the Endocannabinoid System

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

Dissecting the Signaling Pathways Involved in the Crosstalk between Metabotropic Glutamate 5 and Cannabinoid Type 1 Receptors

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