Acute administration of the selective D<sub>3</sub> receptor antagonist SB‐277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats

Ashby, Charles R.; Paul, Mousumi; Gardner, Eliot L.; Heidbreder, Christian; Hagan, Jim J.

doi:10.1002/syn.10188

Cited by 94 publications

(66 citation statements)

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“…Thus, additional work is needed to localize the site of action for SB-277011A's protective effects against stress-triggered reinstatement of drug-seeking behavior. Consistent with our present findings, recent studies show that SB-277011A attenuates cue-controlled cocaine-seeking behavior as assessed by second-order reinforcement (Di Ciano et al 2003), nicotinetriggered nicotine-seeking behavior (Andreoli et al 2003), and heroin-induced conditioned place preference (Ashby et al 2003). All these findings are congruent with D 3 receptors playing an important role in drug reward and drug-seeking.…”

Section: Discussionsupporting

confidence: 93%

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Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats

et al. 2004

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Rationale-The dopamine (DA) D 3 receptor is preferentially expressed in the mesolimbic system. We have previously shown that selective D 3 receptor blockade by the novel D 3 antagonist SB-277011A inhibits cocaine's reinforcing action and cocaine-induced reinstatement of cocaineseeking behavior. © Springer-Verlag 2004Correspondence to: Zheng-Xiong Xi, zxi@intra.nida.nih.gov. NIH Public Access Author ManuscriptPsychopharmacology (Berl). Author manuscript; available in PMC 2013 July 29. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptObjective-In the present study, we investigated whether SB-277011A similarly inhibits stressinduced reinstatement of cocaine-seeking behavior.Methods-Rats were allowed to self-administer cocaine (0.5 mg/kg per infusion, 3 h per session) for 10-14 days, followed by a once-daily extinction session for 7-14 days during which saline was substituted for cocaine. Extinction criteria were fewer than ten lever-presses per 3-h session for at least 3 consecutive days. After cocaine-seeking behavior was extinguished, each animal was tested twice for footshock-stress-induced reinstatement, once with vehicle (25% hydroxypropyl-β-cyclodextrin) and once with one of three doses of SB-277011A in counterbalanced fashion.Results-During the last 3 days of cocaine self-administration (SA), active lever-presses were approximately 100 per session under fixed-ratio 2 reinforcement (~25 mg/kg cocaine per session). After extinction, intermittent footshock (10 min, 0.5 mA, 0.5 s on with a mean inter-shock interval of 40 s) robustly reinstated the cocaine-seeking behavior (8.4±3.6 active lever-presses in last extinction session to 35.3±5.2 in animals after footshock stress). Intraperitoneal (IP) injections of SB-277011A (3, 6, and 12 mg/kg) dose-dependently blocked stress-induced reinstatement of cocaine-seeking. Reinstatement was also blocked by microinjections of SB-277011A (1.5 μg/0.5 μl per side) bilaterally into the nucleus accumbens, but not into the dorsal striatum.Conclusions-The mesolimic DA D 3 receptor plays an important role in mediating stressinduced reinstatement.

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Section: Discussionsupporting

confidence: 93%

“…The present findings, taken together with other recent reports (Vorel et al 2002;Andreoli et al 2003;Ashby et al 2003;Di Ciano et al 2003), suggest that the D 3 receptor may constitute a new target for anti-addiction medications. At the same time, caution along these lines is warranted.…”

Section: Discussionsupporting

confidence: 87%

Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats

et al. 2004

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“…We have recently shown that the administration of 10 mg/kg ip of SB-277011-A significantly attenuates the acquisition and expression of the CPP response to 1.5 mg/ kg ip of heroin in adult male Sprague-Dawley rats [10]. As previously discussed, SB-277011-A alone does not produce place preference or aversion or shift the BSR curve, suggesting that the effect of SB-277011-A on heroin CPP cannot be related to SB-277011-A itself producing reward or aversion.…”

Section: Effect Of Sb-277011-a On Opiate-induced Conditioned Place Prmentioning

confidence: 99%

“…These new subtypes included the D 3 and D 4 receptors, which are homologous to the D 2 receptor, and the D 5 receptor, which is homologous to the D 1 receptor [273,286,292]. A growing body of evidence suggests strongly that the DA D 3 receptor is significantly involved in mechanisms of drug dependence and abuse [6,10,41,43,84,131,167,295]. These findings have underlined the need for selective tools to investigate the role of the DA D 3 receptor in drug dependence.…”

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confidence: 99%

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

Heidbreder

Gardner

et al. 2005

Brain Research Reviews

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The cDNA for the dopamine D 3 receptor was isolated and characterized in 1990. Subsequent studies have indicated that D 3 receptors, as well as D 3 receptor mRNA, are primarily localized in limbic regions in mammals. This finding led to the postulate that D 3 receptors may be involved in drug dependence and addiction. However, this hypothesis has been difficult to test due to the lack of compounds with high selectivity for central D 3 receptors. The interpretation of results from studies using mixed D 2 /D 3 agonists and/or antagonists is problematic because these agents have low selectivity for D 3 over D 2 receptors and it is likely that their actions are primarily related to D 2 receptor antagonism and possibly interaction with other neurotransmitter receptors. Currently, with the synthesis and characterization of new highly selective D 3 receptor antagonists such as SB-277011-A this difficulty has been surmounted. The purpose of the present article is to review, for the first time, the effects of various putative D 3 receptor selective compounds in animal models of drug dependence and addiction. The results obtained with highly selective D 3 receptor antagonists such as SB-277011-A, SB-414796, and NGB-2904 indicate that central D 3 receptors may play an important role in drug-induced reward, drug-taking, and cue-, drug-, and stressinduced reinstatement of drug-seeking behavior. Provided these results can be extrapolated to human drug addicts, they suggest that selective DA D 3 receptor antagonists may prove effective as potential pharmacotherapeutic agents to manage drug dependence and addiction.

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“…30 min prior to testing for reinstatement. The doses of the drugs and the pretreatment times were chosen based upon the previously published pharmacokinetic and pharmacodynamic properties of the three D 3 compounds (Yuan et al, 1998;Pilla et al, 1999;Austin et al, 2001;Beardsley et al, 2001;Robarge et al, 2001;Aujla et al, 2002;Duarte et al, 2003;Garcia-Ladona and Cox, 2003;Heidbreder et al, 2005), our own previous studies (Vorel et al, 2002;Ashby et al, 2003;Campos et al, 2003Campos et al, , 2004Gilbert et al, 2003;Lacroix et al, 2003;Xi et al, 2003Xi et al, , 2004, and pilot studies carried out in preliminary phases of the present investigation.…”

Section: Cue-induced Reinstatement Of Drug-seeking Behaviormentioning

confidence: 99%

Acute administration of SB‐277011A, NGB 2904, or BP 897 inhibits cocaine cue‐induced reinstatement of drug‐seeking behavior in rats: Role of dopamine D₃ receptors

Gilbert

Newman

Gardner

et al. 2005

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Recent studies have shown that the novel dopamine (DA) D 3 receptor antagonists SB-277011A and NGB 2904 inhibit cocaine-and/or stress-induced reinstatement of drug-seeking behavior. The present study sought to determine if SB-277011A, NGB 2904, or BP-897 (a mixed D 3 agonist/ antagonist) similarly inhibit cocaine-associated cue-induced reinstatement of drug-seeking behavior. Long-Evans rats were allowed to self-administer cocaine. Each cocaine infusion was paired with discrete conditioned cue-light and tone. Subsequently, drug-seeking (i.e., leverpressing) behavior was extinguished in the absence of cocaine and cocaine-associated cues. Rats were then tested for cue-induced reinstatement of drug-seeking. We found that cocaine-associated cues evoked robust reinstatement of lever-pressing. Acute intraperitoneal (i.p.) administration of SB-277011A (6, 12, or 24 mg/kg) produced a dose-dependent inhibition of cue-induced reinstatement of drug-seeking behavior by 35, 65, and 85%, respectively, compared to vehicletreated animals. Acute i.p. administration of NGB 2904 (0.1, 1.0, or 5.0 mg/kg) produced a 45, 30, and 70% inhibition of cue-induced reinstatement, respectively, compared to vehicle-treated animals. Acute i.p. administration of either 0.1 or 1 mg/kg of BP 897 did not produce a significant effect on cue-induced reinstatement, whereas a dose of 3 mg/kg produced a 70% inhibition of cueinduced reinstatement. These findings, combined with previous data, suggest that DA D 3 receptor antagonism may underlie the inhibitory effects of SB-277011A and NGB 2904 on cocaine cueinduced reinstatement, while the effects of BP 897 may involve D 3 and non-D 3 receptor mechanisms.

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Acute administration of the selective D₃ receptor antagonist SB‐277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats

Cited by 94 publications

References 10 publications

Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats

Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

Acute administration of SB‐277011A, NGB 2904, or BP 897 inhibits cocaine cue‐induced reinstatement of drug‐seeking behavior in rats: Role of dopamine D₃ receptors

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Acute administration of the selective D3 receptor antagonist SB‐277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats

Cited by 94 publications

References 10 publications

Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats

Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

Acute administration of SB‐277011A, NGB 2904, or BP 897 inhibits cocaine cue‐induced reinstatement of drug‐seeking behavior in rats: Role of dopamine D3 receptors

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Acute administration of the selective D₃ receptor antagonist SB‐277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats

Acute administration of SB‐277011A, NGB 2904, or BP 897 inhibits cocaine cue‐induced reinstatement of drug‐seeking behavior in rats: Role of dopamine D₃ receptors