Acute alcohol consumption downregulates lipoprotein lipase activity in vivo

Zemánková, Kateřina; Makoveichuk, Elena; Vlasáková, Zuzana; Olivecrona, Gunilla; Kovář, J.

doi:10.1016/j.metabol.2015.08.016

Cited by 23 publications

(18 citation statements)

References 17 publications

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“…Smoking constitutes an independent factor to ppHTG 21 with a reduced clearance in postprandial lipid particles which improves after smoking cessation. 22 On the other hand, alcohol consumption favours ppHTG due to an inhibition in lipoprotein lipase (LPL) activity 23 and an increase in very low-density lipoprotein cholesterol (VLDL-c) in the liver. 24 Vigorous physical activity decreases the ppHTG by favouring the clearance of the different postprandial lipid particles.…”

Section: Discussionmentioning

confidence: 99%

“…22 On the other hand, alcohol consumption favours ppHTG due to an inhibition in lipoprotein lipase (LPL) activity 23 and an increase in very low-density lipoprotein cholesterol (VLDL-c) in the liver. As we mentioned previously, different environmental conditions (tobacco and alcohol consumption, body weight, physical activity, lipid-lowering drugs and diet composition between others) are linked with ppHTG.…”

Section: Ofmentioning

confidence: 99%

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Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study

Gómez-Delgado

Alcalá‐Díaz

León-Acuña

et al. 2019

Eur J Clin Investigation

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Background: We try to explore whether long-term consumption of two healthy dietary patterns (low-fat [LF] diet or Mediterranean diet [MedDiet]) interacts with the apolipoprotein E (APOE) single-nucleotide polymorphisms (SNPs: rs439401, rs440446 and rs7412) modulating postprandial hypertriglyceridemia (ppHTG) in coronary heart disease (CHD) patients. Methods and results: We selected patients from the CORDIOPREV study with genotyping and who underwent an oral fat load test (FLT) at baseline and after 3 years follow-up (n = 506). After 3 years of follow-up, we found a gene-diet interaction between the APOE rs439401 SNP and MedDiet. Specifically, T-allele carriers in the MedDiet group showed a more significant decrease in postprandial triglycerides (TG: P = 0.03) and large triacylglycerol-rich lipoproteins (TRLs) TG (large TRLs TG; P = 0.01) compared with CC subjects. Consistently, the area under the curve of TG (AUC-TG; P-interaction = 0.03) and AUC-large TRLs TG (P-interaction = 0.02)were significantly lower in T-allele carriers compared with CC subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Ofmentioning

confidence: 99%

Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study

Gómez-Delgado

Alcalá‐Díaz

León-Acuña

et al. 2019

Eur J Clin Investigation

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“…It has been reported that alcohol consumption is associated with over 200 health conditions including cardiovascular disease. Alcohol has many effects on lipid metabolism and is known to cause triacylglycerol and very low‐density lipoprotein (VLDL) to accumulate in the circulation (Zemánková et al, ). Epidemiological studies have suggested a J‐ or U‐shaped relationship between alcohol consumption and coronary heart diseases (Kannel and Ellison, ; Sacco et al, ).…”

Section: Introductionmentioning

confidence: 99%

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo‐HDL‐Cholesterolemia in a/a Carriers Compared to the G/G Carriers

Imatoh

Yengo

Rocheleau

et al. 2018

Lipids

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It has been reported that polymorphisms within the gene-encoding enzymes related to alcohol metabolism are associated with levels of serum HDL-cholesterol (HDL-C) in East Asian populations. We evaluated the effects of genetic variants within the aldehyde dehydrogenase-2 (ALDH2) gene and the alcohol dehydrogenase-1B (ADH1B) gene on changes in the lipid profile in an 11-year longitudinal study. We genotyped rs1229984 within ADH1B and rs671 within ALDH2. We combined the genetic data with

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“…Others have already reported a positive association between alcohol intake and fasting triglyceride levels, which is dependent on the amount of alcohol consumed and not on the pattern of consumption, as regular and binge drinking had the same effect (Van de Wiel 2011). Part of this effect is due to a decrease in the capacity for triglyceride clearance by alcohol consumption (Zemankova et al 2015). These effects on the lipid profile are independent of BMI, as BMI decreased with increasing frequency of alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

The impact of frequency, pattern, intensity, and type of alcohol consumption, and its combined effect with smoking on inflammation, lipid profile, and the risk of myocardial infarction

Attard

Dingli

Doggen

et al. 2019

J Public Health (Berl.)

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Aim To determine the risk of myocardial infarction (MI) associated with pattern, frequency, and intensity of alcohol consumption, type of alcoholic beverage, and the combined effect of alcohol and smoking on risk of MI, inflammation, and lipid profile. Method A total of 423 cases with a first MI and 465 controls from the Maltese Acute Myocardial Infarction (MAMI) Study were analysed. Data was collected through an extensive interviewer-led questionnaire, along with measurements of various blood parameters. Medians and the Mann-Whitney test were used to assess effect of different drinking patterns, frequency, intensity, and smoking and drinking combinations on hs-CRP and lipid profile. Odds ratios, adjusted for the conventional risk factors of MI (AdjORs), were calculated as an estimate of the relative risk of MI. Results Regular alcohol consumption protected against MI [AdjOR 0.6 (95% CI 0.4-0.9)] while daily binge drinking increased risk [AdjOR 5.0 (95% CI 1.6-15.0)] relative to regular drinkers who did not binge drink. Whereas moderate weekly consumption of wine protected against MI, high weekly consumption of beer conveyed a deleterious effect. Alcohol consumption decreased risk of MI independent of smoking status. Frequent alcohol consumption was associated with higher HDL-, non-HDL-, total cholesterol and triglycerides, and lower hs-CRP. Total and HDL-cholesterol increased and BMI decreased with increasing quantity of weekly alcohol consumption relative to the non-regular drinkers. The effect of smoking on lipid profile and hs-CRP was less pronounced in current drinkers than in those who were non-regular drinkers. Conclusion The protective effect of alcohol consumption was dependent on the pattern, frequency, type, and intensity of alcohol consumed. Alcohol modified the effects of smoking on the lipid profile. Regular drinking attenuated the effect of smoking on hs-CRP and lipid profile.

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Acute alcohol consumption downregulates lipoprotein lipase activity in vivo

Cited by 23 publications

References 17 publications

Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study

Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo‐HDL‐Cholesterolemia in a/a Carriers Compared to the G/G Carriers

The impact of frequency, pattern, intensity, and type of alcohol consumption, and its combined effect with smoking on inflammation, lipid profile, and the risk of myocardial infarction

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