2021
DOI: 10.3389/fimmu.2021.750659
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Acute and Chronic Changes in Gene Expression After CMV DNAemia in Kidney Transplant Recipients

Abstract: Cytomegalovirus (CMV) viremia continues to cause significant morbidity and mortality in kidney transplant patients with clinical complications including organ rejection and death. Whole blood gene expression dynamics in CMV viremic patients from onset of DNAemia through convalescence has not been well studied to date in humans. To evaluate how CMV infection impacts whole blood leukocyte gene expression over time, we evaluated a matched cohort of 62 kidney transplant recipients with and without CMV DNAemia usin… Show more

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Cited by 11 publications
(17 citation statements)
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References 38 publications
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“…When the CMV DNAemia cutoff was increased to >137 IU/mL (clinical CMV, n = 9 subjects), the number of upregulated genes increased to 1,187, while 808 genes were downregulated. This included genes involved in immune activation and T cell signaling, including biological processes such as ‘T cell immunoreceptor,’ ‘T cell receptor gamma,’ ‘Fc receptor,’ and ‘lymphocyte activation.’ 335 of those genes overlapped with published CMV response patterns in renal transplant recipients [ 31 ].…”
Section: Resultsmentioning
confidence: 91%
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“…When the CMV DNAemia cutoff was increased to >137 IU/mL (clinical CMV, n = 9 subjects), the number of upregulated genes increased to 1,187, while 808 genes were downregulated. This included genes involved in immune activation and T cell signaling, including biological processes such as ‘T cell immunoreceptor,’ ‘T cell receptor gamma,’ ‘Fc receptor,’ and ‘lymphocyte activation.’ 335 of those genes overlapped with published CMV response patterns in renal transplant recipients [ 31 ].…”
Section: Resultsmentioning
confidence: 91%
“…The transcriptomic signals for CMV DNAemia (excluding subclinical infection) and rejection were compared with those from publicly available datasets. For CMV DNAemia, we utilized a case-control study examining longitudinal changes in expression upon the onset of DNAemia, defined as CMV DNA concentrations >137 IU/mL (GEO Accession Number: GSE168598) [ 31 ]. This study from Ahn, et al sampled control patients once and then cases prior to DNAemia and again at three timepoints following DNAemia: 1 week, 1 month, and long-term (approximately 1 year).…”
Section: Methodsmentioning
confidence: 99%
“…We utilized a previously reported 6 matching transcriptome data on PBMCs collected from the same cohort with matching time points to perform an integrative multi-omic analysis. Data was downloaded from Gene Expression Omnibus (GSE168598), in which there were 153 overlapping time-matching samples present with an overlap of 186 gene/protein present in both transcriptome and proteome datasets.…”
Section: Methodsmentioning
confidence: 99%
“…We performed a comparative multiome analysis of proteomics data from the plasma samples and transcriptome data available from the matching PBMCs from the same cohort which has been analyzed separately in a previously published paper 6 . Given two different milieus interrogated by transcriptomics (PBMCs) and proteomics (plasma) a significant overlap of target genes/proteins were not expected.…”
Section: Comparing Plasma Proteome With the Transcriptome Of Pbmcs In...mentioning
confidence: 99%
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