Acute and Chronic Effects of Three Pharmaceutical Drugs on the Tropical Freshwater Cladoceran Ceriodaphnia silvestrii

Oliveira, Laira Lúcia Damasceno de; Nunes, Bruno; Antunes, Sara C.; Campitelli-Ramos, Raphael

doi:10.1007/s11270-018-3765-6

Cited by 28 publications

(16 citation statements)

References 101 publications

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“…The mean EC 50 (48h) for C. silvestrii exposed to paracetamol in the present study was 34.49 mg L -1 and the sensitivity to the drug was very close to that observed in the studies byOliveira et al (2018) for the same species (EC 50 , 48h = 40.3 mg L -1 ). For D. magna, EC 50 (48h) values of 30.1 mg L -1 (Kim et al 2007) and 50 mg L -1 (Henschel et al 1997) have been described.…”

supporting

confidence: 87%

“…Ketoprofen (ng L − 1 ) was the second most abundant drug in secondary e uent from Tokyo municipal sewage treatment plants (Nakada et al 2006). This drug was detected in e uent from sewage treatment plants in Canada Paracetamol has been the most widely used drug in the world and is often detected in the aquatic environment (Oliveira et al 2018;An et al 2009). This drug was classi ed as Class 2 -priority pharmaceuticals (Voogt et al 2009), and was considered as a compound with high priority in studies for ecotoxicological assessment (Murray et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Environmental Risk Assessment of Drugs in Tropical Freshwaters Using Ceriodaphnia Silvestrii as Test Organism

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Moreira

et al. 2021

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The identification of drugs in aquatic environments, particularly in surface waters, has generated concerns about their potential toxic effects on the aquatic biota. In this study we evaluated the acute (immobility) and chronic (survival and reproduction) effects of the drugs caffeine, diclofenac sodium salt, ketoprofen, paracetamol and salicylic acid on the cladoceran Ceriodaphnia silvestrii. The environmental risks of these substances for tropical freshwaters were estimated from the risk quotient MEC/PNEC. Sensitivity in acute exposures varied up on the drug as follows: salicylic acid (EC50 = 69.15 mg L− 1) < caffeine (EC50 = 45.94 mg L− 1) < paracetamol (EC50 = 34.49 mg L− 1) < ketoprofen (EC50 = 24.84 mg L− 1) < diclofenac sodium salt (EC50 = 14.59 mg L− 1). Chronic toxicity data showed negative effects of the drugs on reproduction. Paracetamol and salicylic acid caused reduction in fecundity in concentrations starting from 10 mg L− 1 and 35 mg L− 1, respectively. Ketoprofen caused total inhibition at 5 mg L− 1. MEC/PNEC values were relatively low for all drugs. The risk was estimated as low or insignificant, except for caffeine, whose MEC/PNEC value was greater than 1 (moderate risk). Although the concentrations of the drugs that showed a toxic effect on C. silvestrii are still above the detected in the aquatic environment, long-term exposures and the evaluation of other endpoints, may result in potential environmental risks, therefore, they need to be studied. This knowledge is important, as up to now there are neither established limit values or guidelines to control the elimination of drugs in freshwater in Brazil and other countries in tropical regions.

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supporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Environmental Risk Assessment of Drugs in Tropical Freshwaters Using Ceriodaphnia Silvestrii as Test Organism

Caldas

Espíndola

Moreira

et al. 2021

Preprint

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“…On the contrary, there are also studies reporting bioeffect of individual and cocktail mixture of pharmaceuticals using reconstituted analytical grade samples of the pharmaceuticals in specic matrices such as water. [32][33][34][35][36][37]…”

Section: Workflow For Moa Determinationmentioning

confidence: 99%

“…Investigation of its anti-estrogenic, androgenic and antiandrogenic effects, toxic effects of plant growth, mortality and DNA damaging effect on different aquatic organisms have been carried out. [32][33][34]37,160 Interestingly, there are some pharmaceuticals found to have benecial effects, such as venlafaxine and carbamazepine that were found to reduce abnormal embryo development in zebrash at an environmentally-relevant concentration of 0.5 mg L À1 . 36 This is in line with the report of a previous study that documented the highest carbamazepine concentration of 5 mg L À1 in a German wastewater.…”

Section: Endpoints On Individually Targeted Analytesmentioning

confidence: 99%

Monitoring of emerging contaminants of concern in the aquatic environment: a review of studies showing the application of effect-based measures

et al. 2021

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“…Toxic effects of diclofenac on bacteria, algae, microcrustaceans and fish have been also reported at concentrations similar to those measured in aquatic habitats [13]. The chronic use of this emerging contaminant can further intensify the negative consequences to ecosystems [14]. Diclofenac toxicity is not limited to aquatic organisms, but also to wildlife via the consumption of contaminated freshwater, like in the case of the oriental white-backed vultures, which suffered a 95% depletion in their population, due to the widespread presence of this pollutant to the surface water [15].…”

Section: Introductionmentioning

confidence: 73%

Biodegradation Potential and Diversity of Diclofenac-degrading Microbiota in an Immobilized Cell Biofilter

et al. 2019

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Despite that diclofenac has been embodied to the European watch list of priority substances of concern, studies on diclofenac biodegradation are limited and the diversity of diclofenac-degrading microbiota remains unknown. In this work, an immobilized cell biofilter was constructed and operated to evaluate its effectiveness to depurate high strength diclofenac wastewater and to identify the diclofenac-degrading community accommodated in activated sludge by employing high-throughput sequencing techniques. After a two-month adaptation period, biofilter removal efficiencies reached values as high as 97.63 ± 0.62%, whereas utilization of diclofenac in the immobilized cell biofilter led to a drastic pH decrease. Based on Illumina sequencing, the major bacterial taxa identified in the immobilized cell biofilter were members of the species Granulicella pectinivorans and Rhodanobacter terrae, followed by members of the species Castellaniella denitrificans, Parvibaculum lavamentivorans, Bordetella petrii, Bryocella elongata and Rhodopseudomonas palustris. The ability of such taxa to utilize a wide range of carbon sources and to effectively adapt under acidic conditions seemed to be the main parameters, which favored their prevalence in the immobilized cell biofilter. In addition, Wickerhamiella was the predominant fungal taxon in the immobilized cell biofilter, which appears to be actively involved in diclofenac degradation in activated sludge systems.

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Acute and Chronic Effects of Three Pharmaceutical Drugs on the Tropical Freshwater Cladoceran Ceriodaphnia silvestrii

Cited by 28 publications

References 101 publications

Environmental Risk Assessment of Drugs in Tropical Freshwaters Using Ceriodaphnia Silvestrii as Test Organism

Environmental Risk Assessment of Drugs in Tropical Freshwaters Using Ceriodaphnia Silvestrii as Test Organism

Monitoring of emerging contaminants of concern in the aquatic environment: a review of studies showing the application of effect-based measures

Biodegradation Potential and Diversity of Diclofenac-degrading Microbiota in an Immobilized Cell Biofilter

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