Acute and chronic effects of paracetamol exposure on Daphnia magna: how oxidative effects may modulate responses at distinct levels of organization in a model species

Daniel, David; Dionísio, Ricardo; Alkimin, Gilberto Dias de; Nunes, Bruno

doi:10.1007/s11356-018-3788-y

Cited by 45 publications

(17 citation statements)

References 60 publications

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“…This repression could be as a result of the fact that N-acetyl-p-benzoquinone imine (NAPQI), a metabolite of acetaminophen reacts with Glutathione (GSH), therefore sub-chronic dose of acetaminophen may result in a depletion of GSH from hepatocytes [43,21]. This is in concordance with the report of Daniel D, et al [44] on Daphnia magna (a zooplanktonic microcrustacean found in freshwater environments) after a 21day exposure to acetaminophen. Their data showed an unexpected decrease in GST activity.…”

Section: Discussionsupporting

confidence: 84%

“…Henderson CJ, et al [46] showed that GST Pi, the principal GST isoform of acetaminophen metabolism in humans and rats, is significantly decreased in rat liver after being exposed to acetaminophen. GSTs might not be the principal mechanism of detoxification of this drug [44]. Administration of B. coriacea extract only (200 mg/kg b. w) up regulates the mRNA expression of GST.…”

Section: Discussionmentioning

confidence: 98%

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Transcriptional Evaluation of Antioxidant and Anti-Inflammatory Potential of Buchholzia coriacea in Acetaminophen-Induced Sub-Chronic Renal and Hepatic Toxicity

Fakoya¹,

AO²

2021

J Biochem Analyt Stud

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The aim of this research was to evaluate the possible renal and Hepato-protective effects of ethanolic extract of Buchholzia coriacea seed compared to N-acetylcysteine, on gene expression in the liver and kidneys of Wistar rats subjected to sub-chronic dose of paracetamol. Forty wistar rats were divided into eight groups of five rats in each group. Group 1 received only normal diet as control (CTRL). Groups 2-6 received 14.28 mg/kg body weight of Paracetamol (PM). After 6 hours, 200 mg/kg body weight of extract (E1) was given to group 3, 400 mg/kg body weight extracts (E2) given to group 4, 70 and 150 mg/kg body weight of N-acetylcysteine was administered to group 5 and 6 respectively. Groups 7 and 8 received only 200 and 400 mg/kg body weight of extract (E1 and E2) respectively. This schedule was maintained for 90 days.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 98%

Transcriptional Evaluation of Antioxidant and Anti-Inflammatory Potential of Buchholzia coriacea in Acetaminophen-Induced Sub-Chronic Renal and Hepatic Toxicity

Fakoya¹,

AO²

2021

J Biochem Analyt Stud

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“…Kim et al found that after 21 days of NOEC exposure (5.72 mg/mL) no effects on reproduction were observed [10]. In a study by Daniel et al, no effect on reproduction was demonstrated in D. magna [19]. Even in the detailed assessment of wastewater no significant effects on biological assessment were found [20].…”

Section: Results and Disussionmentioning

confidence: 98%

STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERic NANOPARTICLES ON DAFNIA MAGNA

Havelkova

Sehnal

Banas

et al. 2020

NANOCON Conference Proeedings

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Drugs are important xenobiotics in the environment. Their use increases with the growth of the human population, but also in agricultural primary production. Paracetamol (PAR) is a widely used analgesic and antipyretic and its production is still growing. Commonly available drug production technologies are being developed very intensively with nanotechnological modifications for their gradual and targeted release. Nanoparticles (ST/PAR) from starch were prepared: PAR (0, 1, 2, 3, 5 and 10 mg/L) was mixed with citric acid ester in a 1:8 v/v ratio for 30 min at 25 ⁰C. By the centrifugation (16.000 g, 30 min) ST/PAR were obtained in the pellet. The effect of PAR was studied on Daphnia magna Straus (Cladocera, Crustacea). Adult females (70-400 mg) were used for self-evaluation. The EC50 was 3.749 mg/L after 48 h of PAR treatment. Total protein values determined by Lowry method were between 0.5-2.2 mg/mL and by Bradford method between 190-676 mg/L. Antioxidant activity values determined by CUPRAC method were between 4-15 µg/mL GAE and by ABTS method ranged between 40-103 µg/mL GAE. PAR values were between 9-40 µM. Subsequently, the biological activity of the prepared nanoparticles was tested.

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“…For example, Choi et al, (2018) determined that chronic exposure of rainbow trout to this compound causes functional and histological changes in the liver, intestine, and kidney. In addition, Oliveira et al, (2015), detected effects on the oxidative stress of rotifers, while Daniel et al, (2019) and Nunes et al, (2014) found neurological toxicity and enzymatic inactivation in Daphnia magna. Nonetheless, the effects that paracetamol may have on detoxi cation-related genes in aquatic organisms are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Multigenerational analysis of the ecotoxicological effects of paracetamol on the expression of genes HR96 and GST in Daphnia magna

Olivares

Pedreros

Valenzuela

et al. 2022

Preprint

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Various studies have investigated the effects of paracetamol on D. magna, with abundant information on acute and chronic toxicity, but little on multigenerational molecular-level assays. Therefore, this study is focused on a multigenerational investigation of the effects of paracetamol exposure at a constant concentration of 1 mg L− 1 on the expression of the cellular detoxification genes HR96 and GST in D. magna over three generations. The effective concentration of this compound was also determined by studying daphnid survival. The acute exposure results showed mean effective concentrations of EC50 = 11.74 mg L− 1 (11.07–12.48) and EC1 = 1.63 mg L− 1 (1.40–2.62). The multigenerational analysis showed a significant inhibition of both genes in both generation F0 (HR96 = 32.6%, GST = 33.2%) and generation F1 (HR96 = 27.1%, GST = 20.2%). Meanwhile, in F2 a significant induction was observed for GST and HR96, with values of 10.8% and 13.5%, respectively. The response of D. magna over the generations presented a clear induction trend, indicating that this organism is capable of adapting to the contaminant after multiple generations of exposure. Thus, this study shows that paracetamol is more toxic during the first generations and that after 30 days, the drug would not affect the cellular detoxification system.

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Acute and chronic effects of paracetamol exposure on Daphnia magna: how oxidative effects may modulate responses at distinct levels of organization in a model species

Cited by 45 publications

References 60 publications

Transcriptional Evaluation of Antioxidant and Anti-Inflammatory Potential of Buchholzia coriacea in Acetaminophen-Induced Sub-Chronic Renal and Hepatic Toxicity

Transcriptional Evaluation of Antioxidant and Anti-Inflammatory Potential of Buchholzia coriacea in Acetaminophen-Induced Sub-Chronic Renal and Hepatic Toxicity

STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERic NANOPARTICLES ON DAFNIA MAGNA

Multigenerational analysis of the ecotoxicological effects of paracetamol on the expression of genes HR96 and GST in Daphnia magna

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