Acute and chronic effects of oestradiol on left ventricular diastolic function in hypertensive postmenopausal women with left ventricular diastolic dysfunction

Abstract

Background: Left ventricular function changes in the postmenopausal state. However, there are conflicting reports about the effects of oestrogen on left ventricular diastolic function in postmenopausal women. Objective: To evaluate the acute and chronic effects of oestradiol in physiological doses on diastolic heart function in hypertensive postmenopausal women with left ventricular diastolic dysfunction. Methods: A prospective, randomised, double blind, placebo controlled study was used to evaluate the effects of oestradiol in 34 hypertensive women with left ventricular dysfunction. The acute effects of a single 1 mg oral dose of oestradiol or placebo were determined after 90 minutes. The chronic effects of 1 mg oestradiol orally/day or placebo were determined after 12 weeks. Diastolic functional indices (mitral flow and pulmonary venous flow) were assessed by Doppler echocardiography. Results: Though an appropriate serum concentration was achieved, no acute effect of oestradiol administration on left ventricular diastolic function was identified. After 12 weeks of treatment the following changes (mean (SD)) were identified in the oestradiol group: a decrease in isovolumic relaxation time from 127 (23) to 106 (16)

Frequência de disfunção diastólica do ventrículo esquerdo pelo doppler mitral em idosos sadios

“…Although it has been demonstrated that regular physical activity, alcohol consumption and estrogen replacement favorably alter the left ventricular relaxation 22,23 and that acute smoking causes a decrease in the E/A ratio 24,25 , we did not observe any difference regarding the frequency of these variables between the groups. However, our study did not have enough power to measure the influence of these factors on the diastolic function.…”

Effects of Menopause on the Myocardial Velocities and Myocardial Performance Index

“…In most of the studies conducted in the past few years, it has been demonstrated that the decline of cardiac structure and function could be improved by exogenous administration of estrogen alone or combined with progesterone. [20][21][22][23][24][25] Tables 1-4.…”

Effect of estrogen on calcium-handling proteins, β-adrenergic receptors, and function in rat heart

“…Disruption of normal calcium homeostasis with resultant calcium overload is associated with cardiac dysfunction and pathology (Katz and Reuter, 1979;Nitahara et al, 1998;Reeve et al, 2005;Yano et al, 2005). Several human studies have demonstrated that female sex hormones improve contractile performance in postmenopausal women (Alecrin et al, 2004;Fenkci et al, 2003;Sites et al, 1999;Yildirir et al, 2001). Results of some animal studies have shown that ovariectomy depresses and estrogen replacement restores myocardial performance (Schaible et al, 1984;Scheuer et al, 1987).…”