Acute and chronic graft-versus-host disease (GVHD) in patients undergoing allogeneic BMT for thalassaemia major

Innovative Supportive Care Practices for Stem Cell Transplantation in India

“…Short-course methotrexate (MTX) and cyclosporine (CsA) are still the main agents used, but we are exploring other regimes without MTX, particularly where earlier engraftment will significantly reduce transplant-related morbidity, for example, patients with SAA who have infection at the time of transplant, and in patients with Lucarelli Class III thalassemia where sinusoidal obstruction syndrome (SOS) is a major problem [6]. GVHD is treated with steroids and additional agents as required.…”