Acute and Chronic<i>Chlamydia pneumoniae</i>Infection in Pregnancy Complicated with Preeclampsia

Chrisoulidou, Alexandra; Goulis, Dimitrios G.; Iliadou, Paschalia K; Dave, Jitendra R.; Bili, Helen; Simms, C; Redman, Christopher W.G.; Williamson, Catherine

doi:10.3109/10641955.2010.506235

Cited by 12 publications

(6 citation statements)

References 13 publications

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“…The null relationships between C. pneumoniae , HSV-2, CMV, and preeclampsia found in our study are consistent with other longitudinal, 24 case-control, 14 and metaanalysis 25 studies, although literature is conflicting. 8;9;13;16;23 The reason for these discrepancies is not entirely clear, but it is possible that bacterial and viral infections are not universally associated with preeclampsia.…”

Section: Resultssupporting

confidence: 90%

Prenatal Chlamydia trachomatis infection increases the risk of preeclampsia

Haggerty

Klebanoff

Panum

et al. 2013

Pregnancy Hypertension: An International Journal of Women's Car

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The relationship between Chlamydia trachomatis (CT) and preeclampsia was examined longitudinally among 205 cases and 423 normotensive controls nested within the Collaborative Perinatal Project. Antibodies were analyzed at a first prenatal visit (mean 14.2 weeks) and at delivery. Prenatal infections were identified as IgG/IgM seroconversion or a four-fold rise in IgG antibody titers. Although serological evidence of incident prenatal CT infection was uncommon (n=9, 1.4%) in this general pregnant population, infected women were more likely to develop preeclampsia, after adjustment for maternal age, body mass index, smoking status, race and time between blood draws (ORadj 7.2, 95% CI 1.3 – 39.7).

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Section: Resultssupporting

confidence: 90%

Prenatal Chlamydia trachomatis infection increases the risk of preeclampsia

Haggerty

Klebanoff

Panum

et al. 2013

Pregnancy Hypertension: An International Journal of Women's Car

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“…20 Raynor et al and Chrisoulidou et al also found no difference in the rate of seropositivity between PE and normal pregnancy. 21,22 Others, however, found that C.pneumonie may be a coprecipitating factor and its role in development of PE needs to be supported by further studies. Xie et al, examined C.pneumoniae IgG by ELISA and C.pneumoniae genomic DNA loads by real-time PCR in a case-control study on women with PE, normal term pregnancies and non-pregnant controls.…”

Section: Discussionmentioning

confidence: 95%

“…17 However, other studies showed conflicting results. [20][21][22] Xie F et al, recommended need for further studies. 23 Mosbah et al, studied the effect of Helicobacter pylori, Chlamydiae pneumoniae and trachomatis as probable etiological agents of preeclampsia and recommended further studies.…”

mentioning

confidence: 99%

Prevalence of Chlamydia pneumoniae seropositivity in early pregnancy and its association with preeclampsia among primigravidae in Indian population

Sindhu

Yadav

Batra

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Preeclampsia (PE) is a multifactorial disease that might be caused by a concurrent or preceding inflammatory stimulus. Inflammatory changes similar to those reported in chronic Chlamydia pneumoniae infection are seen in PE. It is suggested that persistent or chronic Chlamydia pneumoniae infection might have a role in the pathogenesis of PE and antichlamydial treatment in early pregnancy may prevent reactivation of infection and hence the development of preeclampsia.Methods: This randomized interventional study was conducted to determine the prevalence of C.pneumoniae IgG seropositivity in early pregnancy, its association with PE and the effect of treatment with oral azithromycin. A total of 330 primigravidae included in the study were followed up till delivery. C.pneumoniae IgG antibodies measured by ELISA technique at 14-20 weeks of gestation revealed seropositivity in 32.4%. These women were at higher risk of developing severe PE (odds’ ratio 3.2) as compared to the C. pneumoniae seronegative cases.Results: Treatment with oral azithromycin resulted in reduction in the occurrence of PE amongst the C.pneumoniae seropositive cases; as well as significant reduction in the incidence of low birth weight babies in the C.pneumonie seropositive group (p<0.001, ARR= 0.204).Conclusions: Pregnant women who were C.pneumonia IgG seropositive are at higher risk of developing severe preeclmapsia as compared to the C.pneumoniae seronegative cases. This association needs to be further evaluated.

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“…The first phase refers to hypoperfusion of the placenta, impaired trophoblast invasion, and inadequate remodeling of the uterine spiral arteries, leading in reduced blood supply to the fetus as the spiral arteries remain narrow . During the second phase, metabolic, inflammatory, and thrombotic responses are observed that cause endothelium dysfunction, proteinouria, and multiorgan damage . Placental hypoxia leads to oxidative stress and release into the maternal circulation of trophoblast debris, as well as soluble factors, such as the angiogenic markers soluble endoglin and fms‐like tyrosine kinase 1 (sFlt‐1) .…”

Section: The Pathogenesis Of Pementioning

confidence: 99%

Urine proteomic studies in preeclampsia

Kοlialexi¹,

Mavreli²,

Tounta³

et al. 2015

Proteomics Clinical Apps

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Preeclampsia (PE) is a multisystem disorder of pregnancy that develops after 20 wk of gestation in previously normotensive women and complicates 5-8% of pregnancies. This rapidly progressive syndrome is usually diagnosed when the mother develops hypertension and proteinuria. The only effective treatment is delivery of the baby although early low-dose aspirin has been shown to significantly reduce the risk for PE. Recent advances in proteomic methods of protein separation, identification, and quantitation may allow for the identification of proteins and peptides that could facilitate early detection of disease, improve assessment of prognosis, and allow closer monitoring of women at risk for PE. This review summarizes all currently available markers for prediction and diagnosis of PE and presents urine proteomic studies performed for the identification of novel biomarkers.

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Acute and ChronicChlamydia pneumoniaeInfection in Pregnancy Complicated with Preeclampsia

Abstract: Chronic Cp infection is not more common in women whose pregnancy is complicated with PE as compared to pregnant women without PE. Therefore, no association between Cp infection and PE can be established.

Cited by 12 publications

References 13 publications

Prenatal Chlamydia trachomatis infection increases the risk of preeclampsia

Prenatal Chlamydia trachomatis infection increases the risk of preeclampsia

Prevalence of Chlamydia pneumoniae seropositivity in early pregnancy and its association with preeclampsia among primigravidae in Indian population

Urine proteomic studies in preeclampsia

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