Acute and chronic noradrenergic effects on cortical excitability in healthy humans

Kuo, Min‐Fang; Kuo, Hsiao-I; Paulus, Walter; Batsikadze, Giorgi; Jamil, Asif; Nitsche, Michael A.

doi:10.1016/j.brs.2017.01.430

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…The order of measures was randomized except for the I/O curve, which was always the last measure as it required applying high intensities of TMS, which might induce after-effects on excitability. In the case of single test pulse-generated MEP alterations of >20% during the session in the double pulse conditions, stimulation intensities were adjusted (Kuo et al, 2017). Participants were visually monitored to prevent them from closing the eyes due to sleep pressure.…”

Section: Methodsmentioning

confidence: 99%

Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

Ghanavati

Reinders

et al. 2021

Preprint

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Sleep and cognition are strongly linked via their impact on synaptic strength. Whether and how sleep deprivation modulates human brain physiology and cognition is, however, not well understood. Here we examined how cortical excitability, inducibility of LTP- and-LTD-like plasticity, learning and memory formation and higher-order cognition are affected by overnight sleep deprivation. We show that sleep deprivation upscales cortical excitability due to enhanced glutamate-related cortical facilitation and decreased and/or reversed GABAergic cortical inhibition. We furthermore demonstrate that non-invasive brain stimulation-induced LTP-like plasticity is abolished while LTD-like plasticity converts to excitatory LTP-like under sleep deprivation, likely caused by synaptic saturation and upscaled brain excitability. This was associated with increased synaptic strength measured by EEG theta activity. Finally, we show that learning and memory formation, behavioral counterparts of plasticity, and working memory and attention, which rely on cortical excitability, are impaired during sleep deprivation. Our data show converging effects of sleep deprivation on human brain physiology and cognition.

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Section: Methodsmentioning

confidence: 99%

Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

Ghanavati

Reinders

et al. 2021

Preprint

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“…However, SAI is not modulated by the GABA B receptor agonist baclofen (Turco et al, 2018 ). Finally, NA reuptake inhibitor reboxetine reduces SAI (Kuo et al, 2017 ), potentially through the inhibition of acetylcholine release (Vizi and Pasztor, 1981 ). This pharmacological evidence may suggest that SAI is reflective of GABAergic neurotransmission controlled by cholinergic activity.…”

Section: Paired-pulse Tms Paradigmsmentioning

confidence: 99%

Transcranial Magnetic Stimulation to Assess Exercise-Induced Neuroplasticity

Turco¹,

Nelson²

2021

Front. Neuroergonomics

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Aerobic exercise facilitates neuroplasticity and has been linked to improvements in cognitive and motor function. Transcranial magnetic stimulation (TMS) is a non-invasive technique that can be used to quantify changes in neurophysiology induced by exercise. The present review summarizes the single- and paired-pulse TMS paradigms that can be used to probe exercise-induced neuroplasticity, the optimal stimulation parameters and the current understanding of the neurophysiology underlying each paradigm. Further, this review amalgamates previous research exploring the modulation of these paradigms with exercise-induced neuroplasticity in healthy and clinical populations and highlights important considerations for future TMS-exercise research.

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Acute and chronic noradrenergic effects on cortical excitability in healthy humans

Cited by 2 publications

References 41 publications

Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

Transcranial Magnetic Stimulation to Assess Exercise-Induced Neuroplasticity

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