Acute and chronic psychological stress in coronary disease

Ramachandruni, Srikanth; Handberg, Eileen M.; Sheps, David S.

doi:10.1097/01.hco.0000132321.24004.25

Cited by 34 publications

(16 citation statements)

References 63 publications

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“…Chronic psychosocial stress is a risk factor for the development and progression of cardiovascular disease [CVD; (Hamer, Molloy, & Stamatakis, 2008; Innes, Vincent, & Taylor, 2007; Kopp & Rethelyi, 2004; Ramachandruni, Handberg, & Sheps, 2004)]. Recent research has shown that stress may relate to CVD through its influence on inflammatory processes (Bierhaus, Humpert, & Nawroth, 2006; Steptoe, Hamer, & Chida, 2007).…”

mentioning

confidence: 99%

The association between chronic stress type and C-reactive protein in the multi-ethnic study of atherosclerosis: does gender make a difference?

et al. 2011

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Objective To examine how chronic stress in major life domains [relationship, work, sympathetic-caregiving, financial] relates to CVD risk, operationalized using the inflammatory marker C-Reactive Protein (CRP), and whether gender differences exist. Methods Participants were 6583 individuals aged 45 to 84 years, recruited as part of the Multi-Ethnic Study of Atherosclerosis (MESA). Demographic and behavioral factors, health history, and chronic stress were self-reported. CRP was obtained through venous blood draw. Results In aggregate, gender by chronic stress interaction effects accounted for a significant, albeit small, amount of variance in CRP (p<.01). The sympathetic-caregiving stress by gender interaction was significant (p<.01); the work stress by gender effect approached significance (p=.05). Women with sympathetic-caregiving stress had higher CRP than those without, whereas no difference in CRP by stress group was observed for men. Conclusions Findings underscore the importance of considering gender as an effect modifier in analyses of stress – CVD risk relationships.

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confidence: 99%

The association between chronic stress type and C-reactive protein in the multi-ethnic study of atherosclerosis: does gender make a difference?

et al. 2011

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“…Moreover, in recent decades interest in the relationship between psychological stress and physical health has been growing rapidly (for reviews, see S. Cohen & Herbert, 1996;Schneiderman, Ironson, & Siegel, 2005). Psychological functioning, in particular exposure to chronic psychological stress and the emotional reactions to same, has been implicated in the development and progression to a wide range of physical diseases including diabetes as well as increases in psychosomatic symptoms such as gastrointestinal problems, upper respiratory tract infections (see Cohen & Herbert, 1996;Pinquart & Sorensen, 2003;Ramachandruni, Handberg, & Sheps, 2004). In older caregivers of patients with schizophrenia (Dyck, Short, & Vitaliano, 1999) and dementia (Lee, Colditz, Berkman, & Kawachi, 2003;Schulz & Beach, 1999) caregiver stress found to predict poorer physical health with higher rates of infection and greater risk of cardiovascular morbidity and mortality being observed.…”

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confidence: 99%

The association between stress and physical health in parents caring for children with intellectual disabilities is moderated by children’s challenging behaviours

Gallagher

Whiteley

2012

J Health Psychol

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The present study examined the moderating role of social support and challenging behaviour on the stress-physical health relationship in parents caring for children with intellectual disabilities. Parents of children with intellectual disabilities (n=70) reported more physical health problems compared to control parents (n = 45) and were more likely to visit their general practitioner for treatment. Further, challenging behaviours, but not social support, was found to moderate this association; parents of children with intellectual disabilities reported poorer physical health when both challenging behaviours and stress were perceived to be high. These findings are discussed in light of the literature.

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“…Various psychosocial stressors, including personality, job stress, and social isolation, have been identified as risk factors for the development of atherosclerosis (13,77,117,146). There is also much evidence to suggest that chronic psychosocial stress is a risk factor specifically for the acceleration of coronary artery disease (41,72,78,110,129,143). Given the proinflammatory activity of the RAS and the evident increase in RAS activity during the stress response, there may be a link between recurrent or chronic stress, recurrent or chronic activation of the RAS, and the development of atherosclerosis.…”

Section: Does Intermittent Acute Stress or Chronic Stress Cause Inflamentioning

confidence: 96%

Connecting chronic and recurrent stress to vascular dysfunction: no relaxed role for the renin-angiotensin system

Groeschel¹,

Braam

2011

American Journal of Physiology-Renal Physiology

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The renin-angiotensin system (RAS) is classically considered to be a protective system for volume balance and is activated during states of volume depletion. Interestingly, one of the major pathways activating the system is the sympathetic nervous system, also the primary mediator of the acute stress response. When one further examines the cells mediating the immune site of the response, which is primarily an inflammatory response leading to defense at a locally injured area, these cells all express the ANG II type 1 receptor (AGTR1). Scattered throughout the literature are reports indicating that acute and chronic stress can activate renin and increase plasma levels of components of the RAS. Moreover, there are reports describing that ANG II can modulate the distribution and function of immune cells. Since the inflammatory response is also implicated to be central in the initiation and progression of vascular damage, we propose in this review that recurrent acute stress and chronic stress can induce a state with inflammation, due to ANG II-mediated activation of inflammatory cells, specifically monocytes and lymphocytes. Such a proposal would explain a lot of the observations regarding RAS components in inflammatory cells. Despite its attractiveness, substantial research in this area would be required to substantiate this hypothesis.

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Acute and chronic psychological stress in coronary disease

Abstract: It is suggested that, taken as a whole, evidence for a psychological and social impact on CAD morbidity and mortality is convincing.

Cited by 34 publications

References 63 publications

The association between chronic stress type and C-reactive protein in the multi-ethnic study of atherosclerosis: does gender make a difference?

The association between chronic stress type and C-reactive protein in the multi-ethnic study of atherosclerosis: does gender make a difference?

The association between stress and physical health in parents caring for children with intellectual disabilities is moderated by children’s challenging behaviours

Connecting chronic and recurrent stress to vascular dysfunction: no relaxed role for the renin-angiotensin system

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