Acute and chronic regulation of serum sex hormone-binding globulin levels by plasma insulin concentrations in male noninsulin-dependent diabetes mellitus patients.

Katsuki, Akira; Sumida, Yasuhiro; Murashima, Shuichi; Fujii, Masashi; Ito, Kuninobu; Tsuchihashi, K.; Murata, K; Yano, Yutaka; Shima, Teruo

doi:10.1210/jcem.81.7.8675570

Cited by 33 publications

(19 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors also reported that low SHBG levels in PCOS are associated with the BMI, suggesting that certain signals from adipose tissue may regulate the hepatic production of SHBG. It has been reported that SHBG may constitute an index of IR only in the hyperinsulinemic state (45). These results are similar to those of the present study: Spearman' rank correlations for SHBG versus the insulin sensitivity indices used were lowest in the non-IR group and reached a lower level of significance both in comparison with the IR group and also when all women were taken into account.…”

Section: Discussionsupporting

confidence: 92%

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome

Kajaia¹,

Binder²,

Dittrich³

et al. 2007

eur j endocrinol

View full text Add to dashboard Cite

Background: The aim of the present study is to assess insulin resistance (IR) in women with hyperandrogenic syndrome, which was suggested to replace the term polycystic ovary syndrome by the Androgen Excess Society, and to evaluate whether sex hormone-binding globulin (SHBG) can be used as a predictive marker of IR in hyperandrogenic women. Methods: Clinical, metabolic, and endocrine parameters were measured, and an oral glucose tolerance test was carried out. The women were classified as IR group or non-IR group, in accordance with defined cutoff points for the homeostatic model assessment of IR (HOMA-IR) at R2.5, the quantitative insulin sensitivity check index at %0.33, and the Matsuda insulin sensitivity index (ISI) at %5. Results: The women classified as having IR had a significantly higher body mass index (BMI) and free androgen index (FAI) and showed significantly lower SHBG and high-density lipoprotein (HDL) levels, regardless of the indices used. However, with the Matsuda ISI, generally more women were diagnosed as having IR, and this group had significantly higher total testosterone and triglyceride values, as well as a higher incidence of hirsutism. Conclusions: Women who were classified as being insulin resistant using insulin sensitivity indices showed significantly higher BMI and FAI values and lower SHBG and HDL levels. However, the Matsuda ISI may be more favorable for identifying IR in hyperandrogenic women. SHBG may serve as a predictive marker of IR in these women, particularly in those who are obese.

show abstract

Section: Discussionsupporting

confidence: 92%

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome

Kajaia¹,

Binder²,

Dittrich³

et al. 2007

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…Testosterone is regulated by SHBG and also by insulin and insulin-like growth factors (Plymate et al, 1988;Singh et al, 1990;Pasquali et al, 1995;Katsuki et al, 1996). As with breast cancer, insulin may increase prostate cancer risk by suppressing SHBG levels.…”

Section: Prostate Cancermentioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

View full text Add to dashboard Cite

Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

show abstract

“…For the second experiment, eight subjects (age 23.4 Ϯ 0.6 yr, height 171.1 Ϯ 2.6 cm, weight 61.0 Ϯ 2.6 kg) were tested for a measurement of glucose uptake by using a hyperinsulinemic-euglycemic clamp, according to the method by DeFronzo et al (6), with the aid of a blood glucose monitoring and glucose-insulin infusion system (Artificial Pancreas model STG22; Nikkiso, Tokyo, Japan) (22,45). After an overnight fast, subjects arrived at a clinical research room in Kyoto University Hospital at 8:30 AM and were kept in the supine position with both knees extended.…”

Section: Subjectsmentioning

confidence: 99%

Enhancement of whole body glucose uptake during and after human skeletal muscle low-frequency electrical stimulation

Hamada

Sasaki

Hayashi

et al. 2003

Journal of Applied Physiology

View full text Add to dashboard Cite

. Enhancement of whole body glucose uptake during and after human skeletal muscle low-frequency electrical stimulation. J Appl Physiol 94: 2107-2112, 2003. First published January 31, 2003 10.1152/japplphysiol.00486.2002There is considerable evidence to suggest that electrical stimulation (ES) activates glucose uptake in rodent skeletal muscle. It is, however, unknown whether ES can lead to similar metabolic enhancement in humans. We employed low-frequency ES through surface electrodes placed over motor points of quadriceps femoris muscles. In male subjects lying in the supine position, the highest oxygen uptake was obtained by a stimulation pattern with 0.2-ms biphasic square pulses at 20 Hz and a 1-s on-off duty cycle. Oxygen uptake was increased by approximately twofold throughout the 20-min stimulation period and returned to baseline immediately after stimulation. Concurrent elevation of the respiratory exchange ratio and blood lactate concentration indicated anaerobic glycogen breakdown and utilization during ES. Whole body glucose uptake determined by the glucose disposal rate during euglycemic clamp was acutely increased by 2.5 mg ⅐ kg Ϫ1 ⅐ min Ϫ1 in response to ES and, moreover, remained elevated by 3-4 mg ⅐ kg Ϫ1 ⅐ min Ϫ1 for at least 90 min after cessation of stimulation. Thus the stimulatory effect of ES on whole body glucose uptake persisted not only during, but also after, stimulation. Low-frequency ES may become a useful therapeutic approach to activate energy and glucose metabolism in humans. glucose transport; euglycemic clamp; exercise; insulin sensitivity; oxygen uptake PHYSICAL EXERCISE HAS PROFOUND effects on energy and fuel metabolism in contracting skeletal muscle. It is well established that exercise can directly activate glucose uptake in skeletal muscle by inducing translocation of GLUT-4 glucose transporters to the cell surface via an insulin-independent mechanism (contraction-stimulated glucose transport) (10,11,31,37,49). This phenomenon is considered responsible for the acute effect of exercise on glucose transport, with the majority of glucose being taken up by contracting skeletal muscle. In fact, contraction-stimulated GLUT-4 translocation is not impaired in insulin-resistant conditions such as Type 2 diabetes and obesity (25). Furthermore, the period after exercise is also characterized by a substantial increase in insulin sensitivity that leads to insulin-dependent GLUT-4 translocation and glucose transport as a local phenomenon restricted to exercised muscles (9, 13, 39, 40, 48a). Thus these insulin-independent and -dependent mechanisms of exercise have been widely utilized to prevent individuals from developing glucose intolerance and to improve glycemic control in patients with Type 2 diabetes.Clinically, electrical stimulation (ES) of muscle is useful as a modality of assisting muscle contraction for those who have difficulties in performing voluntary exercise. The use of ES has been traditionally employed for muscle strengthening, maintenance of muscle mass and strength, a...

show abstract

Acute and chronic regulation of serum sex hormone-binding globulin levels by plasma insulin concentrations in male noninsulin-dependent diabetes mellitus patients.

Cited by 33 publications

References 19 publications

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome

Glycemic index in chronic disease: a review

Enhancement of whole body glucose uptake during and after human skeletal muscle low-frequency electrical stimulation

Contact Info

Product

Resources

About