Acute and chronic toxicity assessments of 17β-estradiol (E2) and 17α-ethinylestradiol (EE2) on the calanoid copepod Acartia clausi: Effects on survival, development, sex-ratio and reproduction

Djebbi, Emna; Yahia, Mohamed Néjib Daly; Farcy, Émilie; Pringault, Olivier; Bonnet, Delphine

doi:10.1016/j.scitotenv.2021.150845

Cited by 19 publications

(6 citation statements)

References 57 publications

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“…Currently, there are no reported 24 h LC50 values for A. tonsa exposed to EE2. Compared to 48 h LC50 in the literature for both species, the 24 h LC50 values obtained from both species in this study were much lower than those previously reported for A. tonsa, which has shown a 48 h LC50 of 1.1 mg/L and for A. clausi a 48 h LC50 of 1.2 mg/L [ 20 , 21 ]. Different population-specific responses towards natural and anthropogenic contaminants have been reported in copepods [ 35 , 36 ].…”

Section: Discussioncontrasting

confidence: 87%

“…Three doses of 17α-ethinylestradiol (EE2; Fluka Biochemika co.) were selected for the experimental treatments: 5 ng/L (low), 5 µg/L (medium) and 500 µg/L (high). The low dose corresponds to an environmentally relevant concentration, and medium and high doses have previously been tested in toxicological studies with arthropods and copepods [ 20 , 21 ]. Due to the hydrophobic nature of EE2, acetone was used as a solvent, as proposed by Andersen et al [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…In calanoids, Andersen et al [ 20 ] showed that EE2 had effects on the naupliar development in Acartia tonsa . Additionally, Djebbi et al [ 21 ] demonstrated that exposure to EE2 affected the survival, development and sex ratio in Acartia clausi.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Survival and Disruption of Female Reproductive Output in Two Copepod Species (Acartia clausi and A. tonsa) Exposed to the Model Endocrine Disruptor 17α-Ethinylestradiol

Hafez

Villate

Ortiz-Zarragoitia

2023

Toxics

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Estuaries are heavily impacted by pollutants from different sources such as urban sewage, industrial waste and agricultural runoff. Endocrine-disrupting chemicals (EDCs) are very concerning pollutants to estuarine wildlife, but little is known about their impact on microscopic biota such as zooplankton. The aim of this work was to investigate the effects of a model EDC, the 17α-ethinylestradiol (EE2), on two copepod species inhabiting the Basque coast (Southeastern Bay of Biscay) estuaries: Acartia clausi (autochthonous neritic species) and Acartia tonsa (non-indigenous brackish species). Female copepods were collected at population maximum time (spring for A. clausi and summer for A. tonsa) and exposed individually to 5 ng/L (low), 5 µg/L (medium) and 500 µg/L EE2 (high) doses, from environmental concentrations found in sewage effluents to toxicological concentrations. After 24 h exposure, the survival rate of experimental individuals was checked and the lethal concentration LC50 was calculated. The number of egg-producing females and the amount of egg laying and egg hatching were recorded. The integrated biomarker index (IBR) was calculated to integrate the overall effects of EE2 exposure. Both species had reduced survival rates at 500 µg/L, and the LC50 was lower in A. tonsa (158 µg/L) compared to A. clausi (398 µg/L). The number of eggs laid was significantly reduced in A. clausi at EE2 medium and high doses, while a reduction in the number of eggs in A. tonsa was observed only at the high dose. However, no significant differences were detected in the egg hatching success of exposed A. clausi and A. tonsa. IBR index showed that EE2 had the most detrimental effects on A. tonsa and A. clausi females at the 500 µg/L dose. In conclusion, after 24 h of exposure, EE2 reduced female copepod survival and disrupted reproductive output, but only at high non-environmentally relevant concentrations.

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Section: Discussioncontrasting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

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Reduced Survival and Disruption of Female Reproductive Output in Two Copepod Species (Acartia clausi and A. tonsa) Exposed to the Model Endocrine Disruptor 17α-Ethinylestradiol

Hafez

Villate

Ortiz-Zarragoitia

2023

Toxics

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“…17α-ethinylestradiol exposure can worsen the growth and reproduction of C. elegans [ 56 ]. Estrogen, not only 17α-ethinylestradiol but also 17β-estradiol, exhibited a U-shape curve for A. clause embryos, a resistant gene that is not sensitive to their exposure, a reproductive ability and prosome length was noted in females raised with 100-gram L −1 of 17α-ethinylestradiol [ 57 ]. In addition, higher stress, catalase activity, carboxylesterases activity, metabolic capacity, and cellular damage had been revealed for Mytilus galloprovincialis , which is exposed to the mixture of 17α-ethinylestradiol and salicylic acid, indicating that the potential severe effect will be found for the mixture of estrogens [ 58 ].…”

Section: Biotoxicity Of Pharmaceutical Active Compoundsmentioning

confidence: 99%

Modified polymer membranes for the removal of pharmaceutical active compounds in wastewater and its mechanism-A review

Ratnasari

2023

Bioengineered

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Membrane technology can play a suitable role in removing pharmaceutical active compounds since it requires low energy and simple operation. Even though membrane technology has progressed for wastewater applications nowadays, modifying membranes to achieve the strong desired membrane performance is still needed. Thus, this study overviews a comprehensive insight into the application of modified polymer membranes to remove pharmaceutical active compounds from wastewater. Biotoxicity of pharmaceutical active compounds is first prescribed to gain deep insight into how membranes can remove pharmaceutical active compounds from wastewater. Then, the behavior of the diffusion mechanism can be concisely determined using mass transfer factor model that represented by β and B with value up to 2.004 g h mg −1 and 1.833 mg g −1 for organic compounds including pharmaceutical active compounds. The model refers to the adsorption of solute to attach onto acceptor sites of the membrane surface, external mass transport of solute materials from the bulk liquid to the membrane surface, and internal mass transfer to diffuse a solute toward acceptor sites of the membrane surface with evidenced up to 0.999. Different pharmaceutical compounds have different solubility and relates to the membrane hydrophilicity properties and mechanisms. Ultimately, challenges and future recommendations have been presented to view the future need to enhance membrane performance regarding fouling mitigation and recovering compounds. Afterwards, the discussion of this study is projected to play a critical role in advance of better-quality membrane technologies for removing pharmaceutical active compounds from wastewater in an eco-friendly strategy and without damaging the ecosystem.

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“…The discharge of endocrine disrupting chemicals (EDCs) such as estrogens and nonylphenols from wastewater treatment plants (WWTPs) into surface waters is of great environmental concern. EDCs can induce feminine characteristics in male aquatic organisms [ 1 , 2 ], accumulate in the environment [ 3 ], and their presence in effluent will continue to impede the interest in indirect reuse of reclaimed municipal effluent [ [4] , [5] , [6] ]. Research in this field shows that the removal of EDCs by WWTPs can be optimised by changing operational parameters such as solids retention time (SRT) [ 7 , 8 ], hydraulic retention time (HRT) [ 8 ], temperature, dissolved oxygen and process layout [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of solids and hydraulic retention times on microbial diversity and removal of estrogens and nonylphenols in a pilot-scale activated sludge plant

Mensah,

Petrie,

Scrimshaw

et al. 2023

Heliyon

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Acute and chronic toxicity assessments of 17β-estradiol (E2) and 17α-ethinylestradiol (EE2) on the calanoid copepod Acartia clausi: Effects on survival, development, sex-ratio and reproduction

Cited by 19 publications

References 57 publications

Reduced Survival and Disruption of Female Reproductive Output in Two Copepod Species (Acartia clausi and A. tonsa) Exposed to the Model Endocrine Disruptor 17α-Ethinylestradiol

Reduced Survival and Disruption of Female Reproductive Output in Two Copepod Species (Acartia clausi and A. tonsa) Exposed to the Model Endocrine Disruptor 17α-Ethinylestradiol

Modified polymer membranes for the removal of pharmaceutical active compounds in wastewater and its mechanism-A review

Influence of solids and hydraulic retention times on microbial diversity and removal of estrogens and nonylphenols in a pilot-scale activated sludge plant

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