Acute and long-term effects of acetazolamide in presumed high loop gain sleep apnea

Ni, Yingmeng; Holzer, Rena C.; Thomas, Robert J.

doi:10.1016/j.sleep.2023.04.010

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Precision Treatment Of Osa Using the Traits1

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2024

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Cited by 10 publications

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“…Some data suggest that hypnotics in those with a low ArTH might be of particular benefit [ 119 ]. A combination of a therapy to address UA collapsibility (e.g., CPAP or OAT) and a high LG (acetazolamide or oxygen) may be one way to improve the efficacy of OSA treatment [ 120 , 121 ].…”

Section: Precision Treatment Of Osa Using the Traitsmentioning

confidence: 99%

The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review

Chu,

Zinchuk

2024

JCM

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People with obstructive sleep apnea (OSA) are a heterogeneous group. While many succeed in the treatment of their OSA, many others struggle with therapy. Herein, we discuss how anatomical and physiological factors that cause sleep apnea (OSA traits) impact treatment response and may offer an avenue for more precise care. These OSA traits, including anatomical (upper-airway collapsibility) and physiological (loop gain, airway muscle responsiveness, and arousal threshold) factors, may help determine who can succeed with continuous positive airway pressure, oral appliances, hypoglossal nerve stimulation, or pharmacotherapy. In the future, identifying OSA traits before initiating treatment may help guide the selection of the most effective and tolerable therapy modalities for each individual.

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Section: Precision Treatment Of Osa Using the Traitsmentioning

confidence: 99%