Acute and Long-Term Side Effects of Radiation Therapy in Pediatric Cancer Treatment

Anaesthesia for children with cancer

“…21 , 22 Cancer treatments are not without risks and can have both short- and long-term consequences. 21 , 23 , 24 , 26 , 27 …”

“…Radiation therapy uses a high-energy radiation beam to destroy cancer cells and shrink tumours. 8 , 21 , 27 This leads to cell death of both cancer cells and normal tissues by causing damage to cellular DNA. Radiation may be external or internal, proton or photon.…”

“… 33 Severe mucositis in the mouth, head and neck causes severe pain. 26 , 27 Xerostomia or dry mouth occurs when the salivary gland is damaged secondary to radiation in the head and neck region causing a reduction in saliva production. Analgesia, dietary changes and meticulous oral care and in some children parenteral nutrition are advised as part of the management.…”

“…Analgesia, dietary changes and meticulous oral care and in some children parenteral nutrition are advised as part of the management. 21 , 27 …”

Radiation therapy dose escalation achieves high rates of local control with tolerable toxicity profile in pediatric and young adult patients with Ewing sarcoma

“…Most patients (29 of 32) were enrolled on prospective institutional therapeutic or late effects trials. [11][12][13] We aimed to determine the rate of local failure using focal conformal, limited margin photon or proton radiation and dose escalation for tumors ≥8 cm in greatest dimension at diagnosis in children and young adults with Ewing sarcoma.…”