1980
DOI: 10.1002/path.1711310102
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Acute and persistent ultrastructural changes in rat liver after a single dose of 2‐acetylaminofluorene: Effect of co‐administration of cycloheximide

Abstract: Electron microscope studies have been made of rat hepatic cell morphology, 24 hr, 48 hr and 24 weeks after a single intragastric dose of 2-acetylaminofluorene (2-AFF), alone or together with a single s.c. dose of cycloheximide (CHM). CHM prevents the acute perinuclear glycogen pooling, peripheral displacement of cytoplasmic organelles and nuclear shrinkage induced by 2-AAF. However, the induction by 2-AAF of changes in the granular endoplasmic reticulum, mitochondria and bile canaliculi is enhanced by co-admin… Show more

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