Acute and repeated-dose toxicity of Echinops kebericho Mesfin essential oil

Deyno, Serawit; Tola, Mesfin Asefa; Bazira, Joel; Makonnen, Eyasu; Alele, Paul E.

doi:10.1016/j.toxrep.2020.12.027

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…A comparable result of the major constituents of E. kebericho essential oil was reported by Tariku et. al., (2011) [16] which were dehydrocostus lactone (41.83%), β-phellandrene (10.84%), germacrene B (5.38%), α-selinene (4.13%), α-pinene (3.63%), and β-pinene (3.62%).…”

Section: Resultsmentioning

confidence: 99%

“…The essential oil extracted from roots of E. kebericho has major constituent of eudesm-7 (11) -en-4-ol, caryophyllene oxide, τ-cadinol, β-cubebene, β-patchoulene, longifolene, cyperene, dehydrocostus lactone, β-phellandrene, germacrene B, α-selinene, isoshyobunone, modephene, αpinene, and β-pinene [16] [17]. Moreover, β-sitosterol, stigmasterol, campesterol, β-amyrene, lupeol, and ursolic acid, together with a series of fatty acids were identified from the solvent extract of E. kebericho roots [18] [19].…”

Section: Introductionmentioning

confidence: 99%

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Bioassay-Guided Isolation of Dehydrocostus Lactone from <em>Echinops kebericho</em> as a Leishmanicidal Drug

Abdo,

Tesfaye-Asfaw,

Choudhary

et al. 2024

Preprint

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Several bio-actors are involved in the occurrence of leishmaniasis, which is made too complex for prevention and control options. Currently, all forms of leishmaniasis are being treated with chemical drugs, which have limitations and adverse effects on patients. Searching the bioactive molecules from plant sources allows the development of a novel drug. The essential oil and solvent extract of the roots of E. kebericho showed antileishmanial activity. But looking for biological activities of the isolated active ingredient from tubers of E. kebericho was scant. Thus, the isolation of the leishmanicidal compound from the roots of E. kebericho through a bioassay-guided technique was an aim of this work. Dehydrocostus lactone showed doubled potent than the standard drug miltefosine on leishmanicidal activities against L. major and L. tropica. Besides, the broad-spectrum biological activities of dehydrocostus lactone could be a potential drug candidate for co-infected patients caused by an association of leishmania and another pathogen.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Isolation of Dehydrocostus Lactone from <em>Echinops kebericho</em> as a Leishmanicidal Drug

Abdo,

Tesfaye-Asfaw,

Choudhary

et al. 2024

Preprint

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“…Herein, the rats were devoid of significant change on behavior, gross pathology, body weight, and hematological and biochemical parameters, asserting the safety profile of the leaf extract at a repeated dose of 1500 mg/kg. In addition, subacute toxicity study was conducted on EO obtained from Echinops kebericho tuber at the doses of 100, 200 and 400 mg/kg [ 201 ]. The EO treated groups did not experience significant dose-dependent alterations in body weight, clinical chemistry parameters and relative organ weights.…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Birhan

2022

Chin Med

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Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people worldwide. Patients with status epilepticus (SE) suffer from devastating comorbidities and a high incidence of mortalities. Antiepileptic drugs (AEDs) are the mainstream treatment options for the symptomatic relief of epilepsy. The incidence of refractory epilepsy and the dose-dependent neurotoxicity of AEDs such as fatigue, cognitive impairment, dizziness, attention-deficit behavior, and other side effects are the major bottlenecks in epilepsy treatment. In low- and middle-income countries (LMICs), epilepsy patients failed to adhere to the AEDs regimens and consider other options such as complementary and alternative medicines (CAMs) to relieve pain due to status epilepticus (SE). Plant-based CAMs are widely employed for the treatment of epilepsy across the globe including Ethiopia. The current review documented around 96 plant species (PS) that are often used for the treatment of epilepsy in Ethiopia. It also described the in vivo anticonvulsant activities and toxicity profiles of the antiepileptic medicinal plants (MPs). Moreover, the phytochemical constituents of MPs with profound anticonvulsant effects were also assessed. The result reiterated that a lot has to be done to show the association between herbal-based epilepsy treatment and in vivo pharmacological activities of MPs regarding their mechanism of action (MOA), toxicity profiles, and bioactive constituents so that they can advance into the clinics and serve as a treatment option for epilepsy.

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“…According to Deyno et al.’s 18 investigation on one of the Echinops species, ES can be used safely at high doses. No toxicity signs were detected in an acute oral dose testing up to 2000 mg/kg per body weight.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Efficacy of Echinops spinosus against a Glycerol-Induced Acute Kidney Injury Model

Rizk,

Abdel Moneim,

Abdel-Gaber

et al. 2023

ACS Omega

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Nephroprotection or renal rescue is to revive and restore kidney function after damage, with no need for further dialysis. During acute kidney injury (AKI), sudden and recent reductions in kidney functions occur. Causes are multiple, and prompt intervention can be critical to diminish or prevent morbidity. Echinops spinosus (ES) is a curative plant with proven pharmacological and biological effects including anti-inflammatory, antioxidant, and antibacterial competencies. The principal goal of this research is to scrutinize the nephroprotective features of E. spinosa extract (ESE) against glycerol-induced AKI. Male Wistar albino rats were equally divided into five separated groups: negative control rats (vehicle-injected), ESE control rats (ESE-treated rats), positive control rats, glycerol-induced AKI-model rats (single IM injection of 50% glycerol), and 2 groups of diseased rats but pretreated with different concentrations of ESE for 7 days (ESE 150 + AKI rats and ESE 250 + AKI rats). Kidney tissues were collected and used for histopathology analysis. The relative kidney weight percentage was assessed. ESE effects were investigated via scanning several biomarkers, such as serum urea and creatinine, as kidney function biomarkers. Lactate dehydrogenase (LDH) and creatine kinase (CK) activities were examined as rhabdomyolysis (RM) indicators. Kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL) were also examined to investigate kidney injury. Enzymatic and nonenzymatic oxidative stress markers were analyzed, namely, superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), malondialdehyde (MDA), nitric oxide (NO), and reduced glutathione GSH. Proinflammatory cytokine [tumor necrosis factor-α (TNF-α) and interleukin-1 β (IL-1β)] and the renal proapoptotic protein (Bax) and antiapoptotic protein (Bcl-2) levels were evaluated. Statistical analysis for the resulting data revealed that ESE pretreatment turned AKI-induced biological antioxidant levels to an extent comparable to normal results. Furthermore, ESE decreased kidney function markers and RM-related biomarkers (LDH, CK, Kim-1, and NGAL) compared to those in untreated AKI-model rats. ESE treatment dropped the apoptotic renal Bax levels, enhanced antiapoptotic Bcl-2 manufacture, and disallowed the release of IL-1β and TNF-α. This study revealed the protective effect of ESE as therapeutic medicine against AKI-encouraged oxidative stress, inflammation, and apoptosis. It can be effectively used as adjuvant therapy, helping in renal rescue, and for kidney healing in cases with risk factors of AKI.

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Acute and repeated-dose toxicity of Echinops kebericho Mesfin essential oil

Cited by 8 publications

References 43 publications

Bioassay-Guided Isolation of Dehydrocostus Lactone from <em>Echinops kebericho</em> as a Leishmanicidal Drug

Bioassay-Guided Isolation of Dehydrocostus Lactone from <em>Echinops kebericho</em> as a Leishmanicidal Drug

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Nephroprotective Efficacy of Echinops spinosus against a Glycerol-Induced Acute Kidney Injury Model

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