Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters

Partrick, Katherine A.; Chassaing, Benoît; Beach, Linda Q.; McCann, Katharine E.; Gewirtz, Andrew T.; Huhman, Kim L.

doi:10.1016/j.bbr.2018.02.005

Cited by 63 publications

(57 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it has been payed more and more attention to how extrinsic disturbances affect the gut microbiota in recent years. Many studies reported that environmental factors, host genetics, diet, stress, disease and some other factors influnece the structure of the gut microbiota [31][32][33][34]. But, the possible effects of drinking water on gut community composition and diversity is still poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Mineral water leads to a progressive increase of the microbiota diversity

Zhou¹,

Liu²,

Chen³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: The human gut harbors trillions of microbes, strongly bearing great importance for the health of the host. However, the effect of drinking water on gut microbiota has been poorly understood. Results: In this study, we explored the response of BALB/c mice gut bacterial community (feces) to the different types of drinking water, including commercial bottled mineral water(MW), natural water(NW), purified water(PW) and tap water(TW). Feces were cultured with Brain Heart Infusion Broth dissolved in 4 types of drinking water. 16S rRNA sequencing analysis was performed. Our results reveal that the gut microbiota composition is different among culturing with 4 types of drinking water. As the culture time increases, the number of OTUs significantly decreased except under the aerobic condition of MW. Under the aerobic condition in the 5th day, the considerable differences of alpha diversity index are found between MW and 3 others, consistent to that there are the most unique taxa in MW group. Importantly, the LEfSe analysis discovers that the Bacteroidetes taxa dominate the differences between MW and the other water types. Conclusion: our findings demonstrate that the mineral water can lead to a progressive increase of the microbiota diversity by providing the growth convenience to Bacteroidetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Mineral water leads to a progressive increase of the microbiota diversity

Zhou¹,

Liu²,

Chen³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Shifts in this ratio are associated with behavioral response to social stress 49 as well as with changes in production of the important short chain fatty acid metabolites 50 . A recent study utilizing a Shank3 mutant mouse lacking both the α and β isoforms of Shank3 also had a shift in the ratio of Firmicutes to Bacteroidetes 51 .…”

Section: Dysregulation Of Microbiome Composition and Function In Shanmentioning

confidence: 99%

Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

Osman

Mervosh

Strat

et al. 2020

Preprint

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder with a very high prevalence rate and a chronic disease course beginning in early childhood. Despite the tremendous burden of ASD, there are currently no disease-modifying treatments. Like many neuropsychiatric illnesses ASD has a complex pathophysiology driven by genetic and environmental factors. There is interest in identifying modifiable environmental factors as potential translational research strategies for development of therapeutics for ASD. A rapidly growing body of research demonstrates that the resident bacteria of the gastrointestinal tract, collectively the gut microbiome, have profound influence on brain and behavior. This gut-brain signaling pathway is highly relevant to ASD as the microbiome begins to form at birth, is heavily influenced by environmental factors throughout early life, and begins to stabilize at the same stage of development that symptoms of ASD begin to develop. To investigate potential gene x microbiome interactions in a model of ASD, we utilized mutant mice carrying a deletion of the ASD-associated Shank3 gene (Shank3 KO ), which clinically manifests as Phelan-McDermid syndrome, as a model for genetic risk of ASD. Analysis of the gut microbiome of Shank3 KO mice demonstrated genotype effects on both microbiome composition and metabolite production. Behaviorally, Shank3 KO mice demonstrate decreased social interactions and have altered anxiety and compulsive-like behaviors. Disruption of the microbiome with broad spectrum antibiotics lead to an exacerbation of all behavioral phenotypes in Shank3 KO mice. Additionally, we found that Shank3 KO mice had markedly increased changes in gene expression in the prefrontal cortex following microbiome depletion. Taken together, our results suggest a gene x microbiome interaction in this mouse model for ASD and raise the possibility that targeting the microbiome may be a valid translational research strategy in developing therapeutics for ASD.

show abstract

“…In addition, chronic stress in either adolescence (Dunphy- Doherty, 2018) or adulthood has been shown to modify the microbiome composition coupled with changes in gut barrier function, immunity and behaviour (Bailey, 2011;Bharwani et al, 2016;Burokas et al, 2017;Partrick et al, 2018).…”

Section: The Best Way To a Child's Heart Is Through Their Gutmentioning

confidence: 99%

“…Together these data show that the microbiome may be a key link between the intrauterine environment and adult behavioral changes. In addition, chronic stress in either adolescence (Dunphy‐Doherty, ) or adulthood has been shown to modify the microbiome composition coupled with changes in gut barrier function, immunity and behaviour (Bailey, ; Bharwani et al, ; Burokas et al, ; Partrick et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Similar approaches have been undertaken in Syrian hamsters, a useful model to study social stress due to the fact that they rapidly form dominance hierarchies. A single exposure to social stress induces changes in the gut microbiota that increases following repeated exposures (Partick et al, ). Interestingly, this study found no association between the effects of social stress‐induced changes in the microbiota and HPA axis measures although the composition of the microbiome was different between hamsters that were dominant or submissive.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity

Kentner

Cryan

Brummelte

2018

Developmental Psychobiology

View full text Add to dashboard Cite

Despite the increasing attention to early life adversity and its long‐term consequences on health, behavior, and the etiology of neurodevelopmental disorders, our understanding of the adaptations and interventions that promote resiliency and rescue against such insults are underexplored. Specifically, investigations of the perinatal period often focus on negative events/outcomes. In contrast, positive experiences (i.e. enrichment/parental care//healthy nutrition) favorably influence development of the nervous and endocrine systems. Moreover, some stressors result in adaptations and demonstrations of later‐life resiliency. This review explores the underlying mechanisms of neuroplasticity that follow some of these early life experiences and translates them into ideas for interventions in pediatric settings. The emerging role of the gut microbiome in mediating stress susceptibility is also discussed. Since many negative outcomes of early experiences are known, it is time to identify mechanisms and mediators that promote resiliency against them. These range from enrichment, quality parental care, dietary interventions and those that target the gut microbiota.

show abstract

Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters

Cited by 63 publications

References 72 publications

Mineral water leads to a progressive increase of the microbiota diversity

Mineral water leads to a progressive increase of the microbiota diversity

Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity

Contact Info

Product

Resources

About