Acute and sub-acute oral toxicities of aqueous leaf extract of Vitex madiensis Oliv. in a guinea pig model

Ntabaza, Vianney Ndage; Amuri, Salvius Bakari; Ompey, Jean-Marie Vianney; Simbi, Lumbu; Byanga, Kahumba

doi:10.1016/j.sajb.2022.12.028

Cited by 1 publication

(1 citation statement)

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“…The administration of an ethanol extract of Phaleria macrocarpa in Javanesse quails for two months at doses of 50, 100, and 200 mg/kg BW/day induced liver damage [9]. Giving Madiensis olive extracts, which include flavonoids, to pigs for 28 days at a dose of 1000 mg/kg/day caused liver damage in the form of reduced ALT and AST [34]. It was discovered that prolonged usage of high doses may cause liver damage [35] as in the group with 1000 and 2000 doses of flavonoids from Phaleria macrocarpa fruit extract.…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity Oral Administration of Flavonoids Rich Extract from Phaleria Macrocarpha in Mice

Siskanita Fitriana,

Sri Andarini,

Sutrisno

et al. 2023

a-jhr

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Introduction : Herbal medications are increasingly being used to treat a wide range of illnesses. Phaleria macrocarpa, often known as the crown of the gods, is a plant rich in flavonoids that is frequently used in herbal therapy. The goal of this study was to see what effect a flavonoid-rich extract from phaleria macrocarpa has on the livers of mice. Material and Methode : This study used adult female mice aged 6-8 weeks and weighing 20-30 gr as experimental animals, which were divided into four groups: the control group was given distilled water, group 2 was given a flavonoid dose of 500 mg/kg/day, group 3 was given a flavonoid dose of 1000 mg/kg/day, and group 4 was given a flavonoid dose of 2000 mg/kg/day. The flavonoid-rich extract of Phaleria macrocarpa was administered for 28 days. On the 29th day, the mice were necropsied, followed by surgery and examination of the mice's livers. Result : The flavonoid-rich extract of phaleria macrocarpa at a dose of 500 mg/kg body weight/day resulted in no changes in the weight or histological structure of the liver (p>0.05). Hydropic degeneration and necrosis were observed in the group administered the flavonoid-rich extract of phaleria macrocarpa at doses of 1000 and 2000 mg/kg body weight/day. Conclusion : The administration of a flavonoid-rich extract from Phaleria macrocarpa at a level of 500 mg/kg body weight/day caused no harm in the liver of mice. The use of more than 500 mg/kg body weight/day over an extended period of time has hazardous effects and is not recommended.

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Section: Discussionmentioning

confidence: 99%