Acute and Sub-acute Toxicity of <i>Crataegus Aronia Syn. Azarolus</i> (L.) Whole Plant Aqueous Extract in Wistar Rats

Abstract

Problem statement: Hawthorn comprises more than 200 species worldwide but very few species have been used medicinally. In Mediterranean region, the predominant species of the genus Crataegus is C. aronia syn. Azarolus (L). The extracts or tinctures prepared from the leaves, flowers and/or a fruit has been used traditionally for the treatment of different diseases including different cardiovascular problems. This species (C. aronia syn. Azarolus (L.)) has not been adequately studied. Thus, we aimed to investigate for the possible acute and sub-acute toxicity of C. aronia syn. Azarolus (L.) on Wistar albino rats. Approach: The phytochemical screening of the aqueous extract of C. aronia syn. Azarolus (L.) was determined. Athirty six Wistar rats of both sexes weighing 180-200 g. were divided randomly into sex groups of 6 rats each. The first group was the control group and fed with equal volume of distilled water, while the other 5 groups were given single daily dose of the aqueous extract per os at different doses (100, 200, 500, 1000 and 2000 mg kg

Growth performance and blood profiles of striped catfish (Pangasianodon hypophthalmus) fed leaves extract of Myrmecodia tuberosa

“…Furthermore, they help in reducing hemolysis of RBC and protecting their biological membranes from oxidative damage caused by free radicals (Kitagawa et al 1992;Asgary et al 2005). Therefore, this research seems to be in line with past research that MTE containing flavonoids is capable of being an antioxidant which can be used to maintain the heme iron and enhance erythropoiesis (Akah et al 2008;Uboh et al 2010;Shatoor 2011).…”

Terminalia catappa L. extract improves survival, hematological profile and resistance to Aeromonas hydrophila in Betta sp.

“…Some investigators also report that the antioxidants present in plant extracts might trigger erythropoiesis. This seems to be in agreement with the present study as TCE has flavonoid that, as an antioxidant, might maintain the heme iron in its ferrous state (Akah et al 2007, Uboh et al 2010, Shatoor 2011.…”

The Effects of Terminalia catappa L. Leaves Extract on the Water Quality Properties, Survival and Blood Profile of Ornamental fish (Betta sp) Cultured

“…Also, some investigators reported that the antioxidants present in the plant extract might trigger erythropoiesis and antioxidant activity (Shadu et al, 2006;Vargeshe et al, 2010;Lestari & Susanti, 2015). It seems in agreement with the present study as the TCL has flavonoids that capable as an antioxidant which may maintain the heme iron in its ferrous state and this could enhance erythropoiesis (Akah et al, 2008;Uboh et al., 2010;Shatoor, 2011).…”