Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood

Verster, Joris C.; Volkerts, Edmund R.; Oosterwijck, Armand W. A. A. van; Aarab, Mounir; Bijtjes, Saskia I. R.; Weert, A. Marit de; Eijken, Erik J. E.; Verbaten, Marinus N.

doi:10.1067/mai.2003.63

Cited by 74 publications

(49 citation statements)

References 19 publications

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“…Thus, diphenhydramineinduced sleepiness did not interfere with general mnemonic processes. This finding is in line with previous studies, which consistently report that diphenhydramine does not affect nonemotional, episodic memory (28)(29)(30)(31).…”

Section: Resultssupporting

confidence: 83%

Human genome–guided identification of memory-modulating drugs

Papassotiropoulos

Gerhards

Heck

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits, including neuropsychiatric disorders. It is not clear, however, to what extent this knowledge can be used as a starting point for drug identification, one of the central hopes of the human genome project. The aim of the present study was to identify memory-modulating compounds through the use of human genetic information. We performed a multinational collaborative study, which included assessment of aversive memory-a trait central to posttraumatic stress disorder-and a gene-set analysis in healthy individuals. We identified 20 potential drug target genes in two genomewide-corrected gene sets: the neuroactive ligand-receptor interaction and the long-term depression gene set. In a subsequent double-blind, placebo-controlled study in healthy volunteers, we aimed at providing a proof of concept for the genome-guided identification of memory modulating compounds. Pharmacological intervention at the neuroactive ligand-receptor interaction gene set led to significant reduction of aversive memory. The findings demonstrate that genome information, along with appropriate data mining methodology, can be used as a starting point for the identification of memory-modulating compounds.emotional memory | pharmacology | PTSD

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Section: Resultssupporting

confidence: 83%

Human genome–guided identification of memory-modulating drugs

Papassotiropoulos

Gerhards

Heck

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…Most studies on antihistamines and driving were not conducted in a mixed-sex population. With the exception of the levocetirizine study, 13,33 including 24 men and 24 women (they reported no sex differences for levocetirizine and diphenhydramine), the number of included subjects in studies with mixed-sex populations is too low to provide hard evidence on possible sex differences with sufficient statistical power. Nevertheless, results from these studies suggest that there are no significant sex differences for clemastine, 14,15 mizolastine, 14 and fexofenadine.…”

Section: Sex Effectsmentioning

confidence: 99%

“…Results from a laboratory test battery evaluating memory functioning, cognition, and psychomotor performance were in line with the driving test results. 33 That is, levocetirizine produced no significant impairment in any test. These results suggest that it is safe to drive a car when treated with levocetirizine.…”

Section: Third-generation Antihistaminesmentioning

confidence: 99%

Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic

Verster

Volkerts

2004

Annals of Allergy, Asthma & Immunology

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150

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Background: All antihistamines are capable of crossing the blood-brain barrier and thus may cause sedation. Most antihistamine users are ambulatory patients and therefore presumably drive a car.Objective: To summarize the effects of antihistamine drugs on driving ability. Data Sources and Study Selection: A literature search (MEDLINE and cross-references) was performed using the keywords driving and antihistamine. Sixteen studies using the on-the-road driving test during normal traffic were included in the review. Studies were double-blind and placebo-controlled and included a positive control.Results: First-generation antihistamines (diphenhydramine, triprolidine, terfenadine, dexchlorpheniramine, clemastine) significantly impair driving performance after both one-time and repeated (daily) administration. Second-generation antihistamines (cetirizine, loratadine, ebastine, mizolastine, acrivastine, emedastine, mequitazine) may also impair driving performance, but the magnitude and extent of impairment depend on the administered dose, sex, and time between testing and treatment administration. Tolerance develops after 4 to 5 days of administration, but impairment is not absent. Third-generation antihistamines (fexofenadine and levocetirizine) have been shown to produce no driving impairment after both one-time and repeated administration.Conclusions: First-and second-generation antihistamines may significantly impair driving performance. In the context of driving safety but also taking into account the cardiotoxic properties of some of the second-generation antihistamines, we advise treating patients with third-generation antihistamines such as fexofenadine and levocetirizine.

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“…However, the claims of pharmaceutical companies that second generations H1-antihistamines do not have sedative effect data, which are based on clinical trials, are controversial (Hindmarch et al, 2001;Bender et al, 2003;Verster et al, 2003;Ng et al, 2004;Takahashi et al, 2004). In real life second-generation antihistamines may induce sedation and also impair driving performance.…”

Section: H1-antihistamines Suppress Wheal-and-flare Reaction and Skinmentioning

confidence: 99%

H1-antihistamines suppress wheal-and-flare reaction and skin blood perfusion measured by Laser Dopppler flowmetry: randomized, double-blind, placebo-controlled, crossover design study

Bukovskis¹,

Tirzīte²,

Strazda³

et al. 2010

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood

Cited by 74 publications

References 19 publications

Human genome–guided identification of memory-modulating drugs

Human genome–guided identification of memory-modulating drugs

Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic

H1-antihistamines suppress wheal-and-flare reaction and skin blood perfusion measured by Laser Dopppler flowmetry: randomized, double-blind, placebo-controlled, crossover design study

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