Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain

Raafat, Karim; El-Lakany, Abdalla

doi:10.1186/s12906-015-0780-7

Cited by 40 publications

(30 citation statements)

References 42 publications

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“…Knowing that alleviation of pain is not achieved, we consider one of the following approaches: choose a secondline drug; choose a synthetic or natural drugs having other mechanism of actions; or use drug combinations. [21][22][23][24] Trigeminal Neuralgia (TN) TN is diagnosed in patients who experience chronic NP in the trigeminal nerve area. 25,26 The first-line agent for treatment of TN is carbamazepine.…”

Section: Complex Regional Pain Syndrome (Crps)mentioning

confidence: 99%

“…Compared to tramadol (TRA), the highest doses of tested Ferula (50 mg/kg) exerted remarkable effect towards ameliorating allodynia and thermal hyperalgesia. 24 …”

Section: Ferula Hermonismentioning

confidence: 99%

“…Sambucus nigra (Elder) is another medicinal plant in which Elder is used in the management of diabetes neuropathic pain 24 The inflorescences of Elder comprises valuable phenolic compounds, comprising flavonoids, phenolic acids, proanthocyanidins and catechins. 99 Moreover, Elder demonstrates immune-stimulating, anticancer, 100 antiallergic, antiviral, antibacterial, bronchodilatory, antitussive activity.…”

Section: Sambucus Nigramentioning

confidence: 99%

“…80 Therefore, cannabinoids open doors for a future treatment for NP. Elder has shown significant effects towards amelioration of mechanical allodynia and hyperalgesia 24 Elder were fractioned by RP-column chromatography and RP-HPLC, and showed that the most effective compound was kaempferol. Elder has shown high efficacy against tactile allodynia after a single-administration.…”

mentioning

confidence: 99%

“…Elder has shown high efficacy against tactile allodynia after a single-administration. However, for amelioration of hyperalgesia, needed repeated administration 24 …”

mentioning

confidence: 99%

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Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Raafat¹,

El-Haj²,

Shoumar³

et al. 2017

Phcog J

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Introduction:One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it is extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim of this work is to summarize the findings related to neuropathic pain in terms of etiology, types, diagnosis, current and future management prospective, and identify the gaps in neuropathic pain therapy. Methods: A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of phytotherapies was based upon their potentials in relieving NP in pre-clinical or clinical models. Results: One of the most critical points in this research is that recommendations of the future plans should be focused on the engagement of phytotherapy in the treatment regimen aiming at improving patients' quality of life and reaching optimum efficacy and minimum toxicity. Phytotherapies offer relatively low-risk options to NP patients and have an increasing evidence to be the future of neuropathic pain management. Patients suffering from neuropathy are depending increasingly on phytotherapies; however, they need more clinical trials in order to fully understand their mechanism of actions. Conclusion: Health-care specialists should be regularly informed about neuropathic pain current therapies and promising future phytotherapies, bearing in mind the risk/benefit profile of the utilization of these therapies in the amelioration of NP. Consistent with this criteria NP can be classified into "defined" (all criteria present), "probable" (I and II, in addition either III or IV) or "possible" (I and II, with no confirmatory tests). 3 Moreover, risk factors and epidemiology are cornerstones in understanding NP. Risk factors and EpidemiologyThe literature survey has shown fewer studies on the NP epidemiology. A study on patients evidenced neuropathic pain in 8.2% of adult patients having significantly higher pain intensity than others in a British study. 1,4 Moreover, in a randomly selected adult population using the Douleur Neuropathique four Questions, neuropathic pain were identified in 6.9% of the examined persons in a French study. 5 NP risk factors includes: females, elderly age, minor level of education, living in a rural area worse health (compromised physical, mental and social wellbeing). [5][6][7][8][9] Pathomechanisms Pathomechanisms causing the development of NP are divided into 3 groups: first, electrophysiological properties of the cellular membrane of the first Post-amputation Pain Phantom pain was incident in amputated patients with extremity and stump pain located surrounding the post-surgical stump scar. 31 Due to the fact that strong opiods, tramadol, gabapentin, lidocaine infusions, calcitonin pregabalin or amitriptyline are recommended, evidence of effectiveness ...

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Section: Complex Regional Pain Syndrome (Crps)mentioning

confidence: 99%

“…Compared to tramadol (TRA), the highest doses of tested Ferula (50 mg/kg) exerted remarkable effect towards ameliorating allodynia and thermal hyperalgesia. 24 …”

Section: Ferula Hermonismentioning

confidence: 99%

Section: Sambucus Nigramentioning

confidence: 99%

mentioning

confidence: 99%

“…Elder has shown high efficacy against tactile allodynia after a single-administration. However, for amelioration of hyperalgesia, needed repeated administration 24 …”

mentioning

confidence: 99%

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Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Raafat¹,

El-Haj²,

Shoumar³

et al. 2017

Phcog J

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Infrared‐Assisted Extraction and HPLC‐Analysis of Prunus armeniaca L. Pomace and Detoxified‐Kernel and their Antidiabetic Effects

Raafat

Darra

Saleh

et al. 2017

Phytochemical Analysis

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Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases

Kakarla,

Karuturi,

Siakabinga

et al. 2024

Phytotherapy Research

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Neurological disorders incidences are increasing drastically due to complex pathophysiology, and the nonavailability of disease‐modifying agents. Several attempts have been made to identify new potential chemicals to combat these neurological abnormalities. At present, complete abolishment of neurological diseases is not attainable except for symptomatic relief. However, dietary recommendations to help brain development or improvement have increased over the years. In recent times, cruciferous vegetables and their phytochemicals have been identified from preclinical and clinical investigations as potential neuroprotective agents. The present review highlights the beneficial effects and molecular mechanisms of phytochemicals such as indole‐3‐carbinol, diindolylmethane, sulforaphane, kaempferol, selenium, lutein, zeaxanthin, and vitamins of cruciferous vegetables against neurological diseases including Parkinson's disease, Alzheimer's disease, stroke, Huntington's disease, autism spectra disorders, anxiety, depression, and pain. Most of these cruciferous phytochemicals protect the brain by eliciting antioxidant, anti‐inflammatory, and antiapoptotic properties. Regular dietary intake of cruciferous vegetables may benefit the prevention and treatment of neurological diseases. The present review suggests that there is a lacuna in identifying the clinical efficacy of these phytochemicals. Therefore, high‐quality future studies should firmly establish the efficacy of the above‐mentioned cruciferous phytochemicals in clinical settings.

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Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain

Cited by 40 publications

References 42 publications

Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Infrared‐Assisted Extraction and HPLC‐Analysis of Prunus armeniaca L. Pomace and Detoxified‐Kernel and their Antidiabetic Effects

Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases

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