Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L)

Liju, Vijayasteltar Belsamma; Jeena, Kottarapat; Kuttan, Ramadasan

doi:10.1016/j.fct.2012.11.027

Cited by 158 publications

(107 citation statements)

References 25 publications

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“…Hematological parameters are some of the most sensitive to evaluate the toxicity of medicines in humans and animals, and a blood profile normally gives important information on the reaction of body to damage or stress [18,19]. There were no statistically significant, dosedependent adverse effects on any of the hematological parameters in both male and female rats after 4 weeks of EEOS treatment.…”

Section: Discussionmentioning

confidence: 93%

Acute and Subchronic Oral Toxicity Assessment of the Ethanolic Extract of the root of <i>Oncoba spinosa</i> (Flacourtiaceae) in Rodents

Prasanth¹,

Suba²,

Bommireddy³

et al. 2015

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 93%

Acute and Subchronic Oral Toxicity Assessment of the Ethanolic Extract of the root of <i>Oncoba spinosa</i> (Flacourtiaceae) in Rodents

Prasanth¹,

Suba²,

Bommireddy³

et al. 2015

Trop. J. Pharm Res

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“…Previous study indicated that TEO did not produce any mutagenicity to Salmonella strains with and without activation of S9 mixture (Liju et al, 2013). In this study we have shown TEO has strong antimutagenic potential against know chemical mutagens such as NaN 3 , MNNG, NPD and tobacco as well as 2-AAF which needs metabolic activation.…”

Section: Inhibition Of Cytochrome P450 Enzymes In Vitromentioning

confidence: 55%

“…Earlier studies indicated that TEO did not show any mutagenicity and cytotoxicity up to a concentration of 3 mg/plate (Liju et al, 2013) against S. typhimurium strains. TEO inhibited NaN 3 -induced mutagenicity by 70.3% (TA100), 65.8% (TA102) and 59.2% (TA 1535) at a concentration of 1 mg/plate, ( Figure 1A).…”

Section: Evaluation Of Antimutagenic Potential Of Teomentioning

confidence: 97%

“…These results suggest the role of TEO as chemopreventive and anticancer agent. It is already reported that TEO did not show any toxicity and genotoxicity in rats up to concentration of 500 mg/kg body weight (Liju et al, 2013). FDA has accepted that TEO can be used as food additive and is recommended as GRAS.…”

Section: Inhibition Of Cytochrome P450 Enzymes In Vitromentioning

confidence: 99%

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Chemopreventive Activity of Turmeric Essential Oil and Possible Mechanisms of Action

Liju¹,

Jeena²,

Kuttan³

2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (16), 6575-6580 IntroductionMany human cancers are caused by chemical carcinogens, such as polycyclic aromatic hydrocarbons, heterocyclic amines, aromatic amines etc present in our environment. Continued exposure of these substances to human cells leads to genomic instability, including repair deficiency and accumulation of genetic alteration (Ames, 1983). Mutation is a major factor in carcinogenesis and incidence of cancer may be reduced by decreasing the rate of mutations induced by various chemical mutagens. Many carcinogens are activated through Phase I (cytochrome p450) enzymes present in endoplasmic reticulum of the liver cells. Induction of Phase II detoxification enzymes, such as glutathione S-transferase and UDP-glucuronyl transferase, is another mechanisms of protection against carcinogenesis (Piengchai et al., 2011). Modulating these enzymes may reduce cancer incidence.Spices which are widely used as food ingredient exhibits different pharmacological properties. Essential oils from spices are volatile compounds produced as secondary metabolites. The essential oil from Curcuma longa rhizome is a complex mixture obtained by steam distillation. A total number of 12 components of the essential oil are identified by GC-MS analysis and the principal compounds include ar-turmerone (61%), Department of Biochemistry, Amala Cancer Research Centre, Kerala, India *For correspondence: amalacancerresearch@gmail. com, amalaresearch@hotmail.com AbstractThis study aimed to evaluate the antimutagenic and anticarcinogenic activity of turmeric essential oil as well as to establish biochemical mechanisms of action. Antimutagenicity testing was accomplished using strains and known mutagens with and without microsomal activation. Anticarcinogenic activity was assessed by topical application of 7, 12 -dimethylbenz[a]anthracene (DMBA) as initiator and 1% croton oil as promoter for the induction of skin papillomas in mice. Inhibition of p450 enzymes by TEO was studied using various resorufins and aminopyrene as substrate. Turmeric essential oil (TEO) showed significant antimutagenic activity (p<0.001) against direct acting mutagens such as sodium azide (NaN 3 ), 4-nitro-O-phenylenediamine (NPD) and N-methyl-N-nitro N'nitrosoguanine (MNNG). TEO was found to have significant antimutagenic effect (>90%) against mutagen needing metabolic activation such as 2-acetamidoflourene (2-AAF). The study also revealed that TEO significantly inhibited (p<0.001) the mutagenicity induced by tobacco extract to Salmonella TA 102 strain. DMBA and croton oil induced papilloma development in mice was found to be delayed and prevented significantly by TEO application. Moreover TEO significantly (P<0.001) inhibited isoforms of cytochrome p450 (CYP1A1, CYP1A2, CYP2B1/2, CYP2A, CYP2B and CYP3A) enzymes in vitro, which are involved in the activation of carcinogens. Results indicated that TEO is antimutagenic and anticarcinogenic and inhibition of enzymes (p450) involved in the activation of carcinogen is one of its mecha...

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“…20 Table 1, TP, Alb, Glob and UA in normal controls, diabetic controls, normal HCE treated rats, and diabetic HCE treated rats were not different. BUN in the diabetic controls significantly (p<0.05) increased compared to that in normal controls.…”

Section: Blood Biochemistrymentioning

confidence: 80%

Anti-hyperglycemic and Anti-hyperlipidemic Effects of Extract from Houttuynia cordata Thumb. in Streptozotocin-Induced Diabetic Rats

Poolsil¹,

Promprom²,

Talubmook³

2017

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Aim: Various properties of Houttuynia cordata Thumb. has been reported. However, few studies on its pharmacological effects have been documented. To elucidate whether there are more pharmacological effects of this plant, this study was therefore, carried out to determine the anti-hyperglycemic and anti-hyperlipidemic effects of 80% ethanol extract of H. cordata (HCE). Their antioxidant activity and acute toxicity were also conducted. Methods: HCE at a dose of 250 mg/kg was oral given to Streptozotocin-induced diabetic rats daily for 8 weeks. DPPH assay and HCE at the doses of 1,000, 2,000 and 3,000 mg/kg were employed in antioxidant and acute toxicity studies. Results: HCE lowered FBG in the diabetic, but not in the normal treated rats. HCE did not affect the body weight of all rats, but recovered TP, Alb, Glob, BUN, CREA, UA, TB, AST, ALT, ALP, and reduced the elevated CHO, TG and LDL in the diabetic rats. HCE possessed relatively low antioxidant activity with IC 50 of 115.98± 0.82 µg/mL compared to Vitamin C (42.54+1.37 µg/ml), but did not produce any symptoms of acute toxicity. Conclusions: The extract of H. cordata may have beneficial properties and is a new agent for diabetic treatment and improve renal and hepatic functions.

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Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L)

Cited by 158 publications

References 25 publications

Acute and Subchronic Oral Toxicity Assessment of the Ethanolic Extract of the root of <i>Oncoba spinosa</i> (Flacourtiaceae) in Rodents

Acute and Subchronic Oral Toxicity Assessment of the Ethanolic Extract of the root of <i>Oncoba spinosa</i> (Flacourtiaceae) in Rodents

Chemopreventive Activity of Turmeric Essential Oil and Possible Mechanisms of Action

Anti-hyperglycemic and Anti-hyperlipidemic Effects of Extract from Houttuynia cordata Thumb. in Streptozotocin-Induced Diabetic Rats

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