Acute and Subchronic Toxicity of Chantaleela Recipe in Rats

Abstract

Acute and subchronic toxicities of Chantaleela recipe were studied in both male and female rats. Oral administration of the extract at a single dose of 5,000 mg/kg body weight (5 females, 5 males) did not produce signs of toxicity, behavioral changes, mortality or differences on gross appearance of internal organs. The subchronic toxicity was determined by oral feeding the test substance at the doses of 600, 1,200 and 2,400 mg/kg body weight for 90 days (10 females, 10 males). No signs of abnormalities were observed in the test groups as compared to the controls. The test and control groups (on the 90 th day) and the satellite group (on the 118 th day) were analyzed by measuring their final body and organ weights, taking necropsy, and examining hematological parameters, blood clinical chemistry and histopathology features. The results suggest that Chantaleela recipe did not cause acute or subchronic oral toxicities to female and male rats.

Safety assessment of the Polypodium feei root extract: Acute and subchronic studies

“…The blood system has important functions in delivering oxygen to all body tissues, maintaining vascular integrity and providing necessary immune factors for host defence reaction and so on [ 16 ]. It is very sensitive to toxic compounds and can be altered by the ingestion of some toxic plants [ 17 ]. All parameters measured in this study, counts of red blood cells (RBC), haemoglobin (Hb), haematocrite (Hct), platelet (Plt) and white blood cells (WBC), had values within the normal limits, except, based on the statistical analysis, the platelet count was significantly decreased in the female animals treated with the doses of 400 and 800 mg/kg at the p value of <0.05.…”

The Extended Statistical Analysis of Toxicity Tests Using Standardised Effect Sizes (SESs): A Comparison of Nine Published Papers

“…2 . These give a clearer impression of the increased variation at the higher doses in, for example, Lakmichi [14] and Sireeratawong [17] , but still retain information on outliers. The mean absolute response at each dose level is shown in Fig.…”

“…There is evidence of a dose-response relationship in five or six of the plots (Lakmichi [14] , Sung [15] , Matulka [18] , Johnson [19] , Seo [13] and possibly Sireeratawong [17] ). Budin [16] , Kim [11] and Pucaj [12] seem to not to show a dose-response relationship.…”

“…Sireeratawong et al The authors state that Chantaleela recipe , a traditional Thai folk medicine, is composed of eight kinds of herbal plants [17] . It was fed to rats at doses of 0, 600, 1200, and 2400 mg/kg for 90 days.…”

Heamatological Studies on Sida Rhombifolia Ethanolic Leaf Extract of Micronor Induced Infertility in Female Rats

“…Various medicinal herbs or conventional drugs/chemicals adversely affect certain blood components (Messaudi et al, 2008). Haemolyticanaemia and thromocytopaenia is known to be induced by flavonoids from herbs (Logeswari et al, 2012 This might be due to the participation of neutrophils and monocytes in the process of phagocytosis as scavengers for a wide variety of particulate material (Sireeratawong et al, 2014). It might also be the result of repair processes of hemopoiesis as neutrophils are the first line of defense mechanism (Gangu et al, 2011) (Fig.…”