Acute angle closure glaucoma following the use of intranasal cocaine during dacryocystorhinostomy

Assessing the safety and efficacy of drugs used in preparing the nose for diagnostic and therapeutic procedures: a systematic review

“…Nevertheless, four of the six case reports reviewed highlight adverse effects of this combination as a topical preparation in nasal surgery. This includes acute angle closure glaucoma, thought to be precipitated by the mydriatic effect of adrenaline and cocaine and the effect on the cardiac system: ventricular fibrillation, tachycardia, ventricular ectopics, sustained hypertension and ECG changes (Table ).…”

Acute Bilateral Angle-Closure Glaucoma Related to Intranasal Cocaine Abuse

“…Ravin and Ravin [11] published a case of bilateral corneal ulceration due to topical ocular cocaine instillation and posterior development of an AACG in one eye, and Mitchell and Schwartz [16] reported other unilateral AACGs in a patient that admitted snorting cocaine through the ipsilateral nostril. Three additional unilateral AACG episodes were reported after cocaine instillation in DCR surgical interventions [17,18].…”

Glaucoma in Uveitis

“…Some drugs have an indirect sympathomimetic activity that can induce AACG, such as amphetamines, antidepressants and cocaine. 6 Antidepressants, such as tri and tetracyclic depressants and SSRIs, have been associated with AACG in susceptible individuals due to their cholinergic action. 16 Supraciliary effusion seen on ultrasonography has been identified as the pathogenetic mechanism.…”