Acute anterior compartment syndrome associated with psychogenic polydipsia

Maiocchi, Licia; Bernardi, Elsa

doi:10.1177/1039856211432465

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…Severe pain is the most sensitive clinical marker of anterotibial compartment syndrome. The hyponatremia-rhabdomyolysis-acute compartment syndrome sequence was reported in just two other patients to the best of our knowledge 9 , 10 (another who also had primary hypothyroidism and adrenal insufficiency) and is poorly recognized. Its rarity, possibly due to an occult anatomical susceptibility, does not detract from the importance of this association.…”

Section: Discussionmentioning

confidence: 84%

Rare times rare: The hyponatremia, rhabdomyolysis, anterior compartment syndrome sequence

2016

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LessonPrimary polydipsia occurs in up to 25% of patients with chronic psychiatric disorders (especially schizophrenia), related to the disease, its treatment or both. Urine output fails to match intake >10 L/day and water intoxication may develop. Rhabdomyolysis is a rare complication of hyponatremia, and an acute anterior compartment syndrome of the leg, an emergency, may be very rarely associated.

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Section: Discussionmentioning

confidence: 84%

Rare times rare: The hyponatremia, rhabdomyolysis, anterior compartment syndrome sequence

2016

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“…Psychogenic polydipsia though commonly found with patients of schizophrenia can be a potentially fatal condition. There have been reports of life threatening conditions such as seizure, rhabdomyolysis, aspiration pneumonia, and crural compartment syndrome associated with psychogenic polydipsia [7–9]. There are also reports of death secondary to self-induced water intoxication in patients with schizophrenia [10].…”

Section: Discussionmentioning

confidence: 99%

Psychogenic Polydipsia Complicated to Hyponatremia Induced Seizure in Schizophrenia: A Case Report from Nepal

Sharma

Shah

Sangroula³

et al. 2019

Case Reports in Psychiatry

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Psychogenic polydipsia is one of the common cooccurrences with Schizophrenia and if not addressed can lead to fatal consequences. There are some evidences for pharmacological management of this condition but nonpharmacological management starting from psycho-education to behavioural modification therapy involving family members can be a very effective strategy. We report a case from Nepal where psychogenic polydipsia was complicated to hyponatremia and lead to seizure episodes. We emphasize on asking a routine question about polydipsia in every patient of Schizophrenia in clinics.

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“…The IP with the toxicology results above is water. 18 –21 Although people have died from an overdose of water, water is not regarded as a high-risk IP. In conclusion, an assessment of the exposure is equally important as an assessment of potential toxicity.…”

Section: Structured Risk Assessmentmentioning

confidence: 99%

Structured Risk Assessment for First-in-Human Studies

Iersel¹,

Greenberg

Westrick

2017

Ther Innov Regul Sci

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We describe a structured risk assessment and risk mitigation process that is currently used to evaluate proposed first-in human (FiH) studies. This process balances the inherent risks of an FiH study with maximal protection of subjects. Risk assessment should consider all available data, carefully identifying aspects that may lead to risk for healthy subjects. A structured risk assessment avoids omissions and promotes consistency. Such a risk assessment should be performed for Investigational Products as well as for challenge agents and study procedures. Careful risk assessment recognizes gaps of knowledge and emphasizes that FiH studies are tolerability, not toxicity, studies.

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Acute anterior compartment syndrome associated with psychogenic polydipsia

Abstract: Anterior compartment syndrome is a rare event associated with psychogenic polydipsia. Psychiatrists, physicians and surgeons should be aware of the seriousness of anterior compartment syndrome and its potential to increase morbidity in patients with psychogenic polydipsia.

Cited by 14 publications

References 16 publications

Rare times rare: The hyponatremia, rhabdomyolysis, anterior compartment syndrome sequence

Rare times rare: The hyponatremia, rhabdomyolysis, anterior compartment syndrome sequence

Psychogenic Polydipsia Complicated to Hyponatremia Induced Seizure in Schizophrenia: A Case Report from Nepal

Structured Risk Assessment for First-in-Human Studies

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