Acute Anticholinesterase Pesticide Poisoning Caused a Long-Term Mortality Increase

Huang, Hung Sheng; Hsu, Chien Chin; Weng, Shih‐Feng; Lin, Hung Jung; Wang, Jhi Joung; Su, Shih Bin; Huang, Chun‐Yen; Guo, How‐Ran

doi:10.1097/md.0000000000001222

Cited by 16 publications

(9 citation statements)

References 22 publications

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“…A possible explanation is that the younger population has fewer comorbidities than the older population, and therefore APAP poisoning may become the major contributor to death. This finding is consistent with results of previous studies on poisoning [ 19 , 20 ]. The increased all-cause mortality was higher during the whole follow-up period and was highest in the first 12 months after APAP poisoning.…”

Section: Discussionsupporting

confidence: 94%

Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan

Huang

Weng

et al. 2018

Scand J Trauma Resusc Emerg Med

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BackgroundThe long-term mortality of acetaminophen (APAP) poisoning has not yet been well studied; hence, we conducted this study to gain understanding of this issue.MethodsWe conducted a nationwide population-based cohort study by identifying 3235 participants with APAP poisoning and 9705 participants without APAP poisoning in Taiwan between 2003 and 2012 in the Nationwide Poisoning Database and Longitudinal Health Insurance Database 2000. Participants with APAP poisoning and control subjects were compared for the risk of all-cause mortality by follow-up until 2013.ResultsTwo hundred forty-one participants with APAP poisoning (7.5%) and ninety-four control subjects (1.0%) died during the follow-up. Participants with APAP poisoning had a higher risk of all-cause mortality than the control subjects (incidence rate ratio [IRR], 8.1; 95% confidence interval [CI], 6.3–10.2), especially in the subgroup aged 20 years and younger (IRR, 27.3; 95% CI, 3.5–215.5) and in the first 12 months after poisoning (IRR, 16.0; 95% CI, 9.9–25.7). The increased risk of all-cause mortality was found even up to 2 years after the index poisoning.ConclusionAPAP poisoning was associated with increased long-term mortality. Early referral for intensive aftercare and associated interventions are suggested; however, further studies of the method are needed for clarification.

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Section: Discussionsupporting

confidence: 94%

Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan

Huang

Weng

et al. 2018

Scand J Trauma Resusc Emerg Med

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“…A nationwide study reported that carbon monoxide poisoning was associated with increased long-term mortality, especially in the age subgroup of < 30 years, followed by 30–49 years [ 16 ]. This phenomenon was also found in another study, which reported that anticholinesterase poisoning increased the long-term mortality, especially in the age subgroup of < 35 years [ 17 ]. The authors concluded that the younger population has few comorbidities, and therefore, acute poisonings such as carbon monoxide and anticholinesterase pesticide poisonings may play major roles responsible for their death [ 16 , 17 ].…”

Section: Discussionsupporting

confidence: 75%

Association between acute methanol poisoning and subsequent mortality: a nationwide study in Taiwan

Chung

Chen

et al. 2018

BMC Public Health

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BackgroundMethanol poisoning (MP) often causes acute mortality and morbidities; however, the association between MP and subsequent mortality has not been well studied.MethodsWe conducted a nationwide population-based cohort study by identifying 621 participants with MP from the Nationwide Poisoning Database and 6210 participants without MP from the Longitudinal Health Insurance Database 2000 by matching the index date at a 1:10 ratio between 1999 and 2012. Comparison of the mortality rate between the two cohorts was performed by following up until 2013.ResultsA total of 249 (40%) participants with MP and 154 (2.5%) participants without MP died during the follow-up (p < 0.001). Statistic analysis showed that participants with MP had a higher risk for mortality than did the participants without MP (adjusted hazard ratio [AHR]: 13.48; 95% confidence interval [CI]: 10.76–16.88). The risk of mortality was highest in the first 6 months after MP (AHR: 480.34; 95% CI: 117.55–1962.75). Hypertension, chronic obstructive pulmonary disease, liver disease, malignancy, drug abuse, and lower monthly income also predicted mortality.ConclusionsMP was associated with increased subsequent mortality. Close follow-up for comorbidity control and socioeconomic assistance are suggested for patients with MP.

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“…[ 18 ] Another study mentions a mortality rate due to poisoning with cholinesterase inhibitors (organophosphorus and carbamate) of 12.7%. [ 19 ]…”

Section: Discussionmentioning

confidence: 99%

Epidemiological study on accidental poisonings in children from northeast romania

Nistor

Frăsinariu²,

Rugină³

et al. 2018

Medicine

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Accidental poisonongs are an important cause of morbidity and even mortality, especially in young children.We performed a retrospective observational study on a group of children admitted at the Regional Center of Toxicology at the Children's Emergency Hospital “St. Mary” Iasi with accidental intoxication within a period of 3 years. Data were collected from patients’ files and processed with a SPPS 18.0 database and a 95% confidence interval.During this period, 480 children were admitted with accidental intoxication. Most of them were in the age group of 1 to 2 years (120 cases—24.3%). The etiology of these intoxications was dominated by nonmedication (67%), the most frequent being household chemicals, carbon monoxide, and insecticides. Accidental drug intoxication accounted for 33% of the cases, the main drugs involved being anticonvulsants, nonsteroidal anti-inflammatory drugs, and paracetamol. The mortality caused by accidental poisoning was 0.62%, all deaths owing to nonmedication intoxication.Identifying the epidemiological and evolutionary aspects of accidental intoxications must be a major objective for the health system, given that this pathology can be at least partially avoided and its incidence and severity may be reduced using appropriate measures.

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Acute Anticholinesterase Pesticide Poisoning Caused a Long-Term Mortality Increase

Cited by 16 publications

References 22 publications

Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan

Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan

Association between acute methanol poisoning and subsequent mortality: a nationwide study in Taiwan

Epidemiological study on accidental poisonings in children from northeast romania

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