Acute antidepressant effect of ayahuasca in juvenile non-human primate model of depression

Silva, Flávia Santos da; Silva, Erick Allan dos Santos; Sousa, Geovan Menezes de; Maia‐de‐Oliveira, João Paulo; Rachetti, Vanessa de Paula Soares; Araújo, Dráulio Barros de; Sousa, Maria Bernardete Cordeiro de; Lobão-Soares, Bruno; Galvão-Coelho, Nicole Leite

doi:10.1101/254268

Cited by 4 publications

(3 citation statements)

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“…Some studies with animal models of depression, rodents and non-human primates, observed positive antidepressant effects with the use of ayahuasca or its specific components (81, 82, 83). Using the recently validated translational animal model of depression (84), young marmosets ( Callithrix jacchus ) were treated with nortriptyline during 7 days, a tricyclic antidepressant, or with a single dose of ayahuasca.…”

Section: Discussionmentioning

confidence: 99%

“…Using the recently validated translational animal model of depression (84), young marmosets ( Callithrix jacchus ) were treated with nortriptyline during 7 days, a tricyclic antidepressant, or with a single dose of ayahuasca. It was observed that ayahuasca increased fecal cortisol levels until 48 hours after it ingestion and presented more notable antidepressant effects than nortriptyline, since it reverted depressive-like behaviors and regulated cortisol levels faster and during more time (83). The modulation of HPA axis by antidepressants depend on the type of antidepressant used and the duration of treatment, acute or chronic.…”

Section: Discussionmentioning

confidence: 99%

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A Single Dose Of Ayahuasca Modulates Salivary Cortisol In Treatment-Resistant Depression

Almeida

Silva

et al. 2018

Preprint

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Single Dose Of Ayahuasca Modulates Salivary Cortisol In Treatment-Resistant Depression

Almeida

Silva

et al. 2018

Preprint

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“…Mounting evidence suggests that ayahuasca and its DMT and harmala alkaloids may provide therapeutic benefit for mental health conditions, including depression, anxiety, and substance abuse disorders ( Sarris et al, 2021 ; Uthaug et al, 2021 ; van Oorsouw et al, 2021 ; James et al, 2022 ). Placebo-controlled preclinical studies, as well as double-blind randomized placebo-controlled and observational naturalistic studies have reported antidepressant and anxiolytic effects ( Dos Santos et al, 2016 ; Cameron et al, 2018 ; Palhano-Fontes et al, 2018 ; Santos da Silva et al, 2018 ; Almeida et al, 2019 ; Sarris et al, 2021 ; Zeifman et al, 2021 ). Naturalistic ayahuasca studies have also reported increases in self-compassion, and self-assurance alongside mental health improvements ( Dominguez-Clave et al, 2021 ; Ruffell et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Changes in mental health, wellbeing and personality following ayahuasca consumption: Results of a naturalistic longitudinal study

et al. 2022

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Background: Naturalistic and placebo-controlled studies suggest ayahuasca, a potent psychedelic beverage originating from Indigenous Amazonian tradition, may improve mental health, alter personality structure, and reduce alcohol and drug intake. To better understand ayahuasca’s therapeutic potential and to identify factors that influence therapeutic efficacy, we conducted a naturalistic, longitudinal study of facilitated ayahuasca consumption in naïve participants using a comprehensive battery of self-report questionnaires.Materials and Methods: Ayahuasca naive individuals registering for ayahuasca ceremonies were asked to complete a range of validated questionnaires assessing mental health, alcohol/cannabis use, relationships, personality, and connection to self and spirituality, prior to and 1 month after attending an ayahuasca ceremony. Data for two mental health measures (the DASS-21 and PANAS) and acute subjective effects via the MEQ-30 were also assessed 7 days post-ceremony. Repeated measures ANOVA were used to examine pre-to-post changes, and Pearson correlations explored predictors of improvement in outcomes.Results: Fifty-three attendees (32 women, 21 men) completed pre and post ayahuasca assessments with 55.6% of the sample reporting a complete mystical experience based on the MEQ-30. One-month post-ayahuasca, significant reductions were identified in depression, anxiety, stress, alcohol and cannabis use, body dissociation, accepting external influence, self-alienation, impulsivity, and negative affect/emotionality. Significant increases were identified in positive mood, self-efficacy, authentic living, extraversion, agreeableness, open-mindedness, spirituality, and satisfaction with relationships. While facets of the mystical experience held little predictive validity on outcome measures, baseline traits, particularly high negative emotionality and body dissociation, and low sense of self-efficacy, robustly predicted improvements in mental health and alcohol/cannabis use, and alterations in personality structure which are linked to better mental health.Discussion: This study suggests facilitated ayahuasca consumption in naïve participants may precipitate wide-ranging improvements in mental health, relationships, personality structure, and alcohol use. Associations between baseline traits and therapeutic improvements mark an important first step toward personalized, precision-based medicine and warrant randomized controlled trials to confirm and elaborate on these findings.Contribution Statement: Longitudinal, observational studies and randomized clinical control trials suggest ayahuasca may exert therapeutic effects on mental health and alcohol/cannabis use, and alter personality structure. However, it is unclear if improvements are diagnosis-specific and factors that predict therapeutic gains have yet to be extensively elucidated. This longitudinal, observational study examined the effects of facilitated ayahuasca consumption in naive participants on mental health, alcohol and substance use/abuse, personality traits, relationships, and connection to self and spirituality. We found wide-ranging improvements 1-month post-treatment across these domains, and identified baseline traits which predict pre-to-post changes on primary outcome measures. Improvements were not diagnostic-specific, suggesting ayahuasca may be generally efficacious. Personality traits, body dissociation, and self-efficacy were strong predictors of therapeutic improvements, marking an important first step toward personalized, precision-based medicine. Randomized controlled trials are warranted to confirm and elaborate on these findings.

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Recent Evidence on the Antidepressant Effects of Ayahuasca

Palhano-Fontes

Mota-Rolim

Lobão-Soares

et al. 2021

Ayahuasca Healing and Science

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Acute antidepressant effect of ayahuasca in juvenile non-human primate model of depression

Abstract: 52The incidence of major depression in adolescents, aged between 15 to 18 years, reaches 53 approximately 14%. Usually, this disorder presents a recurrent way, without remission of

Cited by 4 publications

References 55 publications

A Single Dose Of Ayahuasca Modulates Salivary Cortisol In Treatment-Resistant Depression

A Single Dose Of Ayahuasca Modulates Salivary Cortisol In Treatment-Resistant Depression

Changes in mental health, wellbeing and personality following ayahuasca consumption: Results of a naturalistic longitudinal study

Recent Evidence on the Antidepressant Effects of Ayahuasca

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