“…The annual incidence of AD is 27–32 per million,[ 2 8 ] bearing high mortality (80%). [ 1 5 ] The high-risk population includes the patients with advanced age, chronic hypertension (70%–80%), Marfan syndrome (5%–9%), Turner's syndrome, Ehlers–Danlos syndrome, aortic aneurysm, annuloaortic ectasia, aortic arch hypoplasia, coarctation of aorta, bicuspid aortic valve (7%–14%), connective tissue disorders, cocaine abuse, and atherosclerosis.…”