Acute arrest of hematopoiesis induced by infection with Staphylococcus epidermidis following total knee arthroplasty: A case report and literature review

Abstract

Abstract. Infection is one of the most severe complications of total knee prosthesis implantation. The present study reported the case of a 74-year-old female that developed a Staphylococcus epidermidis infection following a cemented total knee arthroplasty. A routine blood test revealed neutropenia and anemia, while S. epidermidis was detected in the peripheral blood and bone marrow. In the present case, S. epidermidis infection led to acute arrest of hematopoiesis (AAH), also known as aplastic crisis, which is the temporary cessation of red cell production. The development of AAH secondary to S. epidermidis infection is rare and, to the best of our knowledge, this is the first case reported in the literature. The present study increased our knowledge of this rare disease and its characteristics, which will enable physicians to be aware of the development of AAH as a rare complication of S. epidermidis infection.

Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy

“…In support of this theory is the known pathophysiology of aplastic anemia in which chronic inflammatory cytokines are correlated with continued stresses leading to bone marrow suppression [ 23 ]. Additionally, there are some data to suggest Staphylococcal peptidoglycan may suppress hematopoiesis; a case of acute arrest of hematopoiesis from a disseminated S. epidermidis infection has been reported [ 24 , 25 ]. Unique to our case was the lack of observable bacteria on her numerous bone marrow biopsies and her lack of improvement with prior aggressive antibiotics that had activity to her clinical isolate.…”

CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment

“…In humans, infection with several pathogens is sometimes associated with reduced red blood cell generation leading to the acute arrest of hematopoiesis ( Bi et al, 2016 ). Interestingly, in B .…”

“…In humans, infection with several pathogens is sometimes associated with reduced red blood cell generation leading to the acute arrest of hematopoiesis (Bi et al, 2016). Interestingly, in B. abortus-infected wt mice the percentage of erythroid progenitors (MEP) in the BM decreases in an Omp25/CD150-dependent manner (Fig.…”

CD150-dependent hematopoietic stem cells sensing ofBrucellainstructs myeloid commitment

“…Infection by several pathogens is sometime associated with reduced red blood cell generation leading to a so called acute arrest of hematopoiesis (AAH) [30]. Interestingly, in the wt mice infected with Brucella the pourcentage of erythroid progenitors (MEP) in the BM decreased in a Omp25/CD150 dependant manner (Supplementary Fig.4a).…”